Assessing Target Specificity of the Small Molecule Inhibitor MARIMASTAT to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling [0.03%]
利用热蛋白组学剖析蛇毒蛋白质毒素 profiling马拉玛斯特特异性的新应用
Cara F Smith,Cassandra M Modahl,David Ceja Galindo et al.
Cara F Smith et al.
New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of medically s...
Generation of a Deep Mouse Brain Spectral Library for Transmembrane Proteome Profiling in Mental Disease Models [0.03%]
用于精神疾病模型跨膜蛋白质组特征分析的深度小鼠脑光谱库的建立
Shanshan Li,Huoqing Luo,Pan Tang et al.
Shanshan Li et al.
Transmembrane (TM) proteins constitute over 30% of the mammalian proteome and play essential roles in mediating cell-cell communication, synaptic transmission, and plasticity in the central nervous system. Many of these proteins, especially...
(Sialyl)Lewis Antigen Expression on Glycosphingolipids, N-, and O-Glycans in Colorectal Cancer Cell Lines is Linked to a Colon-Like Differentiation Program [0.03%]
结直肠癌细胞系中的(Sialyl)Lewis抗原表达与结肠样分化程序相关联
Di Wang,Katarina Madunić,Oleg A Mayboroda et al.
Di Wang et al.
Alterations in the glycomic profile are a hallmark of cancer, including colorectal cancer (CRC). While, the glycosylation of glycoproteins and glycolipids has been widely studied for CRC cell lines and tissues, a comprehensive overview of C...
Unveiling the Peptidase Network Orchestrating Hemoglobin Catabolism in Rhodnius prolixus [0.03%]
揭秘锥蝽Rhodnius prolixu斯体内血红蛋白分解的肽酶网络
Radouane Ouali,Sabrina Bousbata
Radouane Ouali
Chagas disease is transmitted to humans by obligatory hematophagous insects of Triatominae subfamily, which feeds on various hosts to acquire their nutritional sustenance derived from blood proteins. Hemoglobin (Hb) digestion is a pivotal m...
phuEGO: A Network-Based Method to Reconstruct Active Signaling Pathways From Phosphoproteomics Datasets [0.03%]
基于网络的磷酸蛋白质组学数据重建活性信号通路的方法
Girolamo Giudice,Haoqi Chen,Thodoris Koutsandreas et al.
Girolamo Giudice et al.
Signaling networks are critical for virtually all cell functions. Our current knowledge of cell signaling has been summarized in signaling pathway databases, which, while useful, are highly biased toward well-studied processes, and do not c...
Proteomic and Cellular Characterization of Omicron Breakthrough Infections and a Third Homologous or Heterologous Boosting Vaccination in a Longitudinal Cohort [0.03%]
奥密克戎突破性感染的蛋白质组和细胞特征以及纵向队列中的第三次同源或异源加强疫苗接种的特征
Yi Zhang,Zhangfan Fu,Haocheng Zhang et al.
Yi Zhang et al.
The understanding of dynamic plasma proteome features in hybrid immunity and breakthrough infection is limited. A deeper understanding of the immune differences between heterologous and homologous immunization could assist in the future est...
Proteome, Lysine Acetylome, and Succinylome Identify Posttranslational Modification of STAT1 as a Novel Drug Target in Silicosis [0.03%]
肺硅沉着症的蛋白质组、赖氨酸乙酰化和琥珀酰化鉴定出STAT1蛋白翻译后修饰是一个新药物靶点
Tiantian Zhang,Yiyang Wang,Youliang Sun et al.
Tiantian Zhang et al.
Inhalation of crystalline silica dust induces incurable lung damage, silicosis, and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. P...
Quantification Quality Control Emerges as a Crucial Factor to Enhance Single-Cell Proteomics Data Analysis [0.03%]
量化质量控制成为提升单细胞蛋白质组数据分析的关键因素
Sung-Huan Yu,Shiau-Ching Chen,Pei-Shan Wu et al.
Sung-Huan Yu et al.
Mass spectrometry (MS)-based single-cell proteomics (SCP) provides us the opportunity to unbiasedly explore biological variability within cells without the limitation of antibody availability. This field is rapidly developed with the main f...
Replisome Proximal Protein Associations and Dynamic Proteomic Changes at Stalled Replication Forks [0.03%]
停滞复制叉处 replisome 近端蛋白质相互作用及动态蛋白质组变化
Carla-Marie Jurkovic,Jennifer Raisch,Stephanie Tran et al.
Carla-Marie Jurkovic et al.
DNA replication is a fundamental cellular process that ensures the transfer of genetic information during cell division. Genome duplication takes place in S phase and requires a dynamic and highly coordinated recruitment of multiple protein...
Zhongzhi Sun,Zhibin Ning,Daniel Figeys
Zhongzhi Sun
The human gut microbiome is closely associated with human health and diseases. Metaproteomics has emerged as a valuable tool for studying the functionality of the gut microbiome by analyzing the entire proteins present in microbial communit...