Comprehensive Glycomic and Proteomic Analysis of Mouse Striatum and Lateral Hypothalamus Following Repeated Exposures to Cocaine or Methamphetamine [0.03%]
重复暴露于可卡因或甲基苯丙胺后的小鼠纹状体和下丘脑侧翼的全面糖蛋白和蛋白质组分析
Manveen K Sethi,Riccardo Maccioni,John D Hogan et al.
Manveen K Sethi et al.
Substance use disorder is a major concern, with few therapeutic options. Heparan sulfate (HS) and chondroitin sulfate (CS) interact with a plethora of growth factors and their receptors and have profound effects on cellular signaling. Thus,...
Rescoring Peptide Spectrum Matches: Boosting Proteomics Performance by Integrating Peptide Property Predictors Into Peptide Identification [0.03%]
通过在肽识别中集成肽属性预测器来增强蛋白质组学性能的肽谱匹配重评分方法
Mostafa Kalhor,Joel Lapin,Mario Picciani et al.
Mostafa Kalhor et al.
Rescoring of peptide spectrum matches originating from database search engines enabled by peptide property predictors is exceeding the performance of peptide identification from traditional database search engines. In contrast to the peptid...
Improved Mass Spectrometry-Based Methods Reveal Abundant Propionylation and Tissue-Specific Histone Propionylation Profiles [0.03%]
改进的基于质谱的方法发现大量的丙酰化及组织特异性的组蛋白丙酰化图谱
Alessandro Vai,Roberta Noberini,Chiara Ghirardi et al.
Alessandro Vai et al.
Histone posttranslational modifications (PTMs) have crucial roles in a multitude of cellular processes, and their aberrant levels have been linked with numerous diseases, including cancer. Although histone PTM investigations have focused so...
Differential Analysis of Cereblon Neosubstrates in Rabbit Embryos Using Targeted Proteomics [0.03%]
基于靶向蛋白质组学的兔胚胎Cereblon新底物差异蛋白分析
Joel D Federspiel,Natasha R Catlin,William S Nowland et al.
Joel D Federspiel et al.
Targeted protein degradation is the selective removal of a protein of interest through hijacking intracellular protein cleanup machinery. This rapidly growing field currently relies heavily on the use of the E3 ligase cereblon (CRBN) to tar...
Global View of Domain-Specific O-Linked Mannose Glycosylation in Glycoengineered Cells [0.03%]
甘露糖工程细胞O连接聚糖的全局视图分析
Lorenzo Povolo,Weihua Tian,Sergey Y Vakhrushev et al.
Lorenzo Povolo et al.
Protein O-linked mannose (O-Man) glycosylation is an evolutionary conserved posttranslational modification that fulfills important biological roles during embryonic development. Three nonredundant enzyme families, POMT1/POMT2, TMTC1-4, and ...
Histone Chaperone Deficiency in Arabidopsis Plants Triggers Adaptive Epigenetic Changes in Histone Variants and Modifications [0.03%]
组蛋白伴侣缺陷的拟南芥植物触发组蛋白变体和修饰的适应性表观遗传变化
Michal Franek,Martina Nešpor Dadejová,Pavlína Pírek et al.
Michal Franek et al.
At the molecular scale, adaptive advantages during plant growth and development rely on modulation of gene expression, primarily provided by epigenetic machinery. One crucial part of this machinery is histone posttranslational modifications...
Cerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome [0.03%]
脑脊液蛋白质组学揭示可逆性 cerebral vasoconstriction 综合征的分子标志物
Jhih-Ci Yang,Shih-Pin Chen,Yen-Feng Wang et al.
Jhih-Ci Yang et al.
Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder characterized by repetitive thunderclap headaches and reversible cerebral vasoconstriction. The pathophysiological mechanism of this mysterious syndrom...
Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2 [0.03%]
外源性肝素硫酸酯酶Sulf-2的糖基化抑制剂半乳凝集素-3结合蛋白
Aswini Panigrahi,Julius Benicky,Reem Aljuhani et al.
Aswini Panigrahi et al.
Human extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of ...
Enhanced Proteomic Coverage in Tissue Microenvironment by Immune Cell Subtype Library-Assisted DIA-MS [0.03%]
基于免疫细胞亚型库的DIA-MS提高组织微环境中的蛋白覆盖度
Jhih-Ci Yang,Tzi-Hui Hsu,Ciao-Syuan Chen et al.
Jhih-Ci Yang et al.
Immune cells that infiltrate the tumor microenvironment (TME) play crucial roles in shaping cancer development and influencing clinical outcomes and therapeutic responses. However, obtaining a comprehensive proteomic snapshot of tumor-infil...
Proteome Birthdating Reveals Age-Selectivity of Protein Ubiquitination [0.03%]
蛋白质泛素化的选择性与蛋白质谱.ageSELECTIVE蛋白质泛素化及蛋白质组年龄鉴定
Michael E Meadow,Sarah Broas,Margaret Hoare et al.
Michael E Meadow et al.
Within a cell, proteins have distinct and highly variable half-lives. As a result, the molecular ages of proteins can range from seconds to years. How the age of a protein influences its environmental interactions is a largely unexplored ar...