Systematic Proteome Profiling of Maternal Plasma for Development of Preeclampsia Biomarkers [0.03%]
系统分析母体血浆蛋白组以研发子痫前期生物标志物
Ji Hyae Lim,Jae Min Lim,Hyeong Min Lee et al.
Ji Hyae Lim et al.
Preeclampsia (PE) is a hypertensive disorder of pregnancy with various clinical symptoms. However, traditional markers for the disease including high blood pressure and proteinuria are poor indicators of the related adverse outcomes. Here, ...
optiPRM: A Targeted Immunopeptidomics LC-MS Workflow With Ultra-High Sensitivity for the Detection of Mutation-Derived Tumor Neoepitopes From Limited Input Material [0.03%]
高效的基于质谱的免疫肽组学工作流程用于从有限样本中检测突变衍生肿瘤新表位
Mogjiborahman Salek,Jonas D Förster,Jonas P Becker et al.
Mogjiborahman Salek et al.
Personalized cancer immunotherapies such as therapeutic vaccines and adoptive transfer of T cell receptor-transgenic T cells rely on the presentation of tumor-specific peptides by human leukocyte antigen class I molecules to cytotoxic T cel...
Development of a Fit-For-Purpose Multi-Marker Panel for Early Diagnosis of Pancreatic Ductal Adenocarcinoma [0.03%]
一种用于早期诊断胰腺导管腺癌的适合目的的多标志物面板的发展
Hyeonji Kim,Sunghyun Huh,Jungkap Park et al.
Hyeonji Kim et al.
Pancreatic ductal adenocarcinoma (PDAC) suffers from a lack of an effective diagnostic method, which hampers improvement in patient survival. Carbohydrate antigen 19-9 (CA19-9) is the only FDA-approved blood biomarker for PDAC, yet its clin...
Jennifer G Abelin,Andrea L Cox
Jennifer G Abelin
Over the past 30 years, immunopeptidomics has grown alongside improvements in mass spectrometry technology, genomics, transcriptomics, T cell receptor sequencing, and immunological assays to identify and characterize the targets of activate...
Universal Identification of Pathogenic Viruses by Liquid Chromatography Coupled with Tandem Mass Spectrometry Proteotyping [0.03%]
液质联用蛋白型谱技术鉴定致病病毒
Clément Lozano,Olivier Pible,Marine Eschlimann et al.
Clément Lozano et al.
Accurate and rapid identification of viruses is crucial for an effective medical diagnosis when dealing with infections. Conventional methods, including DNA amplification techniques or lateral-flow assays, are constrained to a specific set ...
One-step N-Terminomics Based on Isolation of Protein N-Terminal Peptides From LysargiNase Digests by Tip-Based Strong Cation Exchange Chromatography [0.03%]
基于Tip型强阳离子交换色谱从LysargiNase消化液中富集蛋白质N端肽的一锅式N末端组学研究
Kazuya Morikawa,Hiroshi Nishida,Koshi Imami et al.
Kazuya Morikawa et al.
We have developed a one-step isolation method for protein N-terminal peptides from LysargiNase digests by pipette tip-based strong cation exchange (SCX) chromatography. This CHAMP-N (CHromatographic AMplification of Protein N-terminal pepti...
ST3GAL1 Promotes Malignant Phenotypes in Intrahepatic Cholangiocarcinoma [0.03%]
ST3GAL1促进肝内胆管癌恶性表型的作用及机制研究
Fanghua Chen,Ke Gao,Yan Li et al.
Fanghua Chen et al.
Intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis, and elucidation of the molecular mechanisms underlying iCCA malignancy is of great significance. Glycosylation, an important post-translational modification, is closely associated...
Molecular Signatures of Neurodegenerative Diseases Identified by Proteomic and Phosphoproteomic Analyses in Aging Mouse Brain [0.03%]
基于老化小鼠脑蛋白组及磷酸化蛋白组分析的神经退行性疾病的分子标志物识别
Rodrigo Mohallem,Allison J Schaser,Uma K Aryal
Rodrigo Mohallem
A central hallmark of neurodegenerative diseases is the irreversible accumulation of misfolded proteins in the brain by aberrant phosphorylation. Understanding the mechanisms underlying protein phosphorylation and its role in pathological p...
A Proteogenomic Pipeline for the Analysis of Protein Biosynthesis Errors in the Human Pathogen Candida albicans [0.03%]
一种分析人类病原菌白色念珠菌蛋白质生物合成错误的蛋白组基因组工作流程
Inês Correia,Carla Oliveira,Andreia Reis et al.
Inês Correia et al.
Candida albicans is a diploid pathogen known for its ability to live as a commensal fungus in healthy individuals but causing both superficial infections and disseminated candidiasis in immunocompromised patients where it is associated with...
Are Internal Fragments Observable in Electron Based Top-Down Mass Spectrometry? [0.03%]
基于电子的自上而下质谱中可以观察到内部片段吗？
Neven N Mikawy,Carolina Rojas Ramírez,Steven A DeFiglia et al.
Neven N Mikawy et al.
Protein tandem mass spectrometry (MS/MS) often generates sequence-informative fragments from backbone bond cleavages near the termini. This lack of fragmentation in the protein interior is particularly apparent in native top-down mass spect...