Claudia Cavarischia-Rega,Karan Sharma,Julia C Fitzgerald et al.
Claudia Cavarischia-Rega et al.
Dopaminergic neurons participate in fundamental physiological processes and are the cell type primarily affected in Parkinson's disease. Their analysis is challenging due to the intricate nature of their function, involvement in diverse neu...
ZASP: A Highly Compatible and Sensitive ZnCl2 Precipitation-Assisted Sample Preparation Method for Proteomic Analysis [0.03%]
一种用于蛋白质组分析的高兼容性和灵敏度的ZnCl2沉淀辅助样品制备方法(ZASP)
Xianfeng Shao,Yuanxuan Huang,Rong Xu et al.
Xianfeng Shao et al.
Universal sample preparation for proteomic analysis that enables unbiased protein manipulation, flexible reagent use, and low protein loss is required to ensure the highest sensitivity of downstream liquid chromatography-mass spectrometry (...
Identification of a Proteomic Signature for Predicting Immunotherapy Response in Patients With Metastatic Non-Small Cell Lung Cancer [0.03%]
鉴定出针对预测转移性非小细胞肺癌患者免疫治疗反应的蛋白组标志物
Patricia Mondelo-Macía,Jorge García-González,Luis León-Mateos et al.
Patricia Mondelo-Macía et al.
Immunotherapy has improved survival rates in patients with cancer, but identifying those who will respond to treatment remains a challenge. Advances in proteomic technologies have enabled the identification and quantification of nearly all ...
GRable Version 1.0: A Software Tool for Site-Specific Glycoform Analysis With Improved MS1-Based Glycopeptide Detection With Parallel Clustering and Confidence Evaluation With MS2 Information [0.03%]
GRable版本1.0：一种用于位点特异性糖基衍生物分析的软件工具，具有改进的基于MS1的糖肽检测功能，使用并行聚类和MS2信息置信度评估功能
Chiaki Nagai-Okatani,Daisuke Tominaga,Azusa Tomioka et al.
Chiaki Nagai-Okatani et al.
High-throughput intact glycopeptide analysis is crucial for elucidating the physiological and pathological status of the glycans attached to each glycoprotein. Mass spectrometry-based glycoproteomic methods are challenging because of the di...
LC-SRM Combined With Machine Learning Enables Fast Identification and Quantification of Bacterial Pathogens in Urinary Tract Infections [0.03%]
结合液相色谱串联质谱及机器学习技术实现尿路感染快速病原菌鉴定和定量研究
Clarisse Gotti,Florence Roux-Dalvai,Ève Bérubé et al.
Clarisse Gotti et al.
Urinary tract infections (UTIs) are a worldwide health problem. Fast and accurate detection of bacterial infection is essential to provide appropriate antibiotherapy to patients and to avoid the emergence of drug-resistant pathogens. While ...
Phage Immunoprecipitation and Sequencing-a Versatile Technique for Mapping the Antibody Reactome [0.03%]
噬菌体免疫沉淀和测序-一种用于绘制抗体反应组的灵活技术
Gustav N Sundell,Sheng-Ce Tao
Gustav N Sundell
Characterizing the antibody reactome for circulating antibodies provide insight into pathogen exposure, allergies, and autoimmune diseases. This is important for biomarker discovery, clinical diagnosis, and prognosis of disease progression,...
Pupylation-Based Proximity-Tagging of FERONIA-Interacting Proteins in Arabidopsis [0.03%]
基于泛素化依赖的FERONIA互作蛋白临近标记法
Zhuoran Lin,Di Liu,Yifan Xu et al.
Zhuoran Lin et al.
The plasma membrane-localized receptor kinase FERONIA (FER) plays critical roles in a remarkable variety of biological processes throughout the life cycle of Arabidopsis thaliana. Revealing the molecular connections of FER that underlie the...
Secretome Analysis Using Affinity Proteomics and Immunoassays: A Focus on Tumor Biology [0.03%]
基于亲和蛋白质组学和免疫分析的分泌组研究及其在肿瘤生物学中的应用
Vanessa M Beutgen,Veronika Shinkevich,Johanna Pörschke et al.
Vanessa M Beutgen et al.
The study of the cellular secretome using proteomic techniques continues to capture the attention of the research community across a broad range of topics in biomedical research. Due to their untargeted nature, independence from the model s...
Immunopeptidomics Mapping of Listeria monocytogenes T Cell Epitopes in Mice [0.03%]
利用免疫肽谱分析技术绘制鼠单核细胞增生李斯特菌T细胞表位图
Adillah Gul,Lecia L Pewe,Patrick Willems et al.
Adillah Gul et al.
Listeria monocytogenes is a foodborne intracellular bacterial model pathogen. Protective immunity against Listeria depends on an effective CD8+ T cell response, but very few T cell epitopes are known in mice as a common animal infection mod...
Variation of Site-Specific Glycosylation Profiles of Recombinant Influenza Glycoproteins [0.03%]
重组流感糖蛋白位点特异性聚糖谱的差异性分析
Zachary C Goecker,Meghan C Burke,Concepcion A Remoroza et al.
Zachary C Goecker et al.
This work presents a detailed determination of site-specific N-glycan distributions of the recombinant influenza glycoproteins hemagglutinin (HA) and neuraminidase. Variation in glycosylation among recombinant glycoproteins is not predictab...