Beatrix M Ueberheide,Sahana Mollah,Benjamin A Garcia
Beatrix M Ueberheide
Our genome is not made of naked DNA but a fiber (chromatin) composed of DNA and proteins packaged into our chromosomes. The basic building block of chromatin is the nucleosome, which has two copies of each of the proteins called histones (H...
Functional Analysis of MS-Based Proteomics Data: From Protein Groups to Networks [0.03%]
基于质谱的蛋白质组学数据的功能分析：从蛋白复合体到网络
Marie Locard-Paulet,Nadezhda T Doncheva,John H Morris et al.
Marie Locard-Paulet et al.
Mass spectrometry-based proteomics allows the quantification of thousands of proteins, protein variants, and their modifications, in many biological samples. These are derived from the measurement of peptide relative quantities, and it is n...
Targeted Dynamic Phospho-Proteogenomic Analysis of Gastric Cancer Cells Suggests Host Immunity Provides Survival Benefit [0.03%]
靶向胃癌细胞的磷酸化蛋白质基因分型分析表明宿主免疫利于患者生存益处
Kohei Kume,Midori Iida,Takeshi Iwaya et al.
Kohei Kume et al.
Despite of massive emergence of molecular targeting drugs, the mainstay of advanced gastric cancer (GC) therapy is DNA-damaging drugs. Using a reverse-phase protein array-based proteogenomic analysis of a panel of 8 GC cell lines, we identi...
John R Yates rd
John R Yates rd
A personal narrative of my time in the Hunt laboratory and beyond is provided. The impact of the Hunt laboratory on the analysis of peptides and proteins by tandem mass spectrometry is described in the context of the time. ...
Dehydrin Client Proteins Identified Using Phage Display Affinity Selected Libraries Processed With Paired-End Phage Sequencing [0.03%]
利用噬菌体展示亲和选择文库配对末端噬菌体重建鉴定脱水素结合客户蛋白
Sandra Helena Unêda-Trevisoli,Lynnette M A Dirk,Francisco Elder Carlos Bezerra Pereira et al.
Sandra Helena Unêda-Trevisoli et al.
The late embryogenesis abundant proteins (LEAPs) are a class of noncatalytic, intrinsically disordered proteins with a malleable structure. Some LEAPs exhibit a protein and/or membrane binding capacity and LEAP binding to various targets ha...
High-Throughput and High-Sensitivity Biomarker Monitoring in Body Fluid by Fast LC SureQuant IS-Targeted Quantitation [0.03%]
基于LC-SureQuant快速确证性定量的高通量体液痕量生物标志物监测技术研究
Konstantinos Kalogeropoulos,Simonas Savickas,Aleksander M Haack et al.
Konstantinos Kalogeropoulos et al.
Targeted proteomics methods have been greatly improved and refined over the last decade and are becoming increasingly the method of choice in protein and peptide quantitative assays. Despite the tremendous progress, targeted proteomics assa...
Mass Spectrometry-Based Proteomics for the Masses: Peptide and Protein Identification in the Hunt Laboratory During the 2000's [0.03%]
海量质谱蛋白质组学：寻猎实验室在21世纪头十年里的肽和蛋白质鉴定历程
Jessica R Chapman
Jessica R Chapman
There has been a rapid increase in the number of individuals utilizing mass spectrometry-based proteomics to study complex biological systems and questions since the start of the 2000's. Building off the advancements in ionization and liqui...
Peter C Fridy,Michael P Rout,Natalia E Ketaren
Peter C Fridy
The camelid single-domain antibody fragment, commonly referred to as a nanobody, achieves the targeting power of conventional monoclonal antibodies (mAbs) at only a fraction of their size. Isolated from camelid species (including llamas, al...
Analysis of Antibiotic Response in Clinical Wound Pseudomonas aeruginosa Isolates: Unveiling Proteome Dynamics of Tobramycin-Tolerant Phenotype [0.03%]
临床伤口中铜绿假单胞菌分离株抗生素反应分析：托 bramycin 耐受表型蛋白质组动力学研究
Kasandra Buchholtz,Rosa Jersie-Christensen,Karen Angeliki Krogfelt et al.
Kasandra Buchholtz et al.
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic human pathogen, causing serious chronic infections. P. aeruginosa can adapt efficiently to antibiotic stressors via different genotypic or phenotypic strategies such as resistance a...
Mapping Start Codons of Small Open Reading Frames by N-Terminomics Approach [0.03%]
采用N-末端蛋白质组学方法绘制小开放阅读框的起始密码子地图
Mingbo Peng,Tianjing Wang,Yujie Li et al.
Mingbo Peng et al.
sORF-encoded peptides (SEPs) refer to proteins encoded by small open reading frames (sORFs) with a length of less than 100 amino acids, which play an important role in various life activities. Analysis of known SEPs showed that using non-ca...