Deep Learning Enhances Precision of Citrullination Identification in Human and Plant Tissue Proteomes [0.03%]
深度学习提高对人类和植物组织蛋白质组瓜氨酸化的鉴定精度
Wassim Gabriel,Rebecca Meelker Gonzalez,Sophia Laposchan et al.
Wassim Gabriel et al.
Citrullination is a critical yet understudied post-translational modification (PTM) implicated in various biological processes. Exploring its role in health and disease requires a comprehensive understanding of the prevalence of this PTM at...
Proteogenomic Profiling Reveals Small ORFs and Functional Microproteins in Activated T Cells [0.03%]
蛋白质组学分析揭示活化T细胞中存在小ORF和功能微蛋白
Yang Yang,Chuangmiao Chen,Kecheng Li et al.
Yang Yang et al.
Noncanonical micropeptides or called novel microproteins, i.e., polypeptides mostly under 10 kDa, are encoded by genomic sequences that have been previously annotated as noncoding but now known as small open reading frames (sORFs). The rece...
COMPARATIVE ANALYSIS OF THE TOTAL PROTEOME IN NONALCOHOLIC STEATOHEPATITIS: IDENTIFICATION OF POTENTIAL BIOMARKERS [0.03%]
非酒精性脂肪肝病的总蛋白组比较分析：潜在生物标记物的鉴定
Eda Ates,Hien Thi My Ong,Seung-Min Yu et al.
Eda Ates et al.
Nonalcoholic fatty liver disease (NAFLD) is a hepatic condition characterized excessive fat accumulation in the liver with advanced stage nonalcoholic steatohepatitis (NASH), potentially leading to liver fibrosis, cirrhosis, and cancer. Cur...
Integrated analysis of proteome and transcriptome profiling reveals pan-cancer-associated pathways and molecular biomarkers [0.03%]
整合蛋白质组和转录组图谱揭示泛癌关联通路及分子标志物
Guo-Sheng Hu,Zao-Zao Zheng,Yao-Hui He et al.
Guo-Sheng Hu et al.
Understanding dysregulated genes and pathways in cancer is critical for precision oncology. Integrating mass spectrometry-based proteomic data with transcriptomic data presents unique opportunities for systematic analyses of dysregulated ge...
Ciliopathy-associated missense mutations in IFT140 are tolerated by the inherent resilience of the IFT machinery [0.03%]
鞭毛病相关IFT140内含子富集的错义突变被纤毛发生设备的内在稳定性所耐受
Tina Beyer,Gaurav D Diwan,Tobias Leonhard et al.
Tina Beyer et al.
Genotype-phenotype correlations of rare diseases are complicated by low patient number, high phenotype variability and compound heterozygosity. Mutations may cause instability of single proteins, and affect protein complex formation or over...
Localized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress [0.03%]
分子伴侣VCP/p97调控氧化压力下定位严格的K63泛素信号通路
Austin O Maduka,Sandhya Manohar,Matthew W Foster et al.
Austin O Maduka et al.
Under stress conditions, cells reprogram their molecular machineries to mitigate damage and promote survival. Ubiquitin signaling is globally increased during oxidative stress, controlling protein fate and supporting stress defenses at seve...
PathwayPilot: A User-Friendly Tool for Visualizing and Navigating Metabolic Pathways [0.03%]
路径通路导向仪：用于代谢途径可视化的用户友好型工具
Tibo Vande Moortele,Pieter Verschaffelt,Qingyao Huang et al.
Tibo Vande Moortele et al.
Metaproteomics, the study of collective proteomes in environmental communities, plays a crucial role in understanding microbial functionalities affecting ecosystems and human health. Pathway analysis offers structured insights into the bioc...
Proteomic diversity in bacteria: Insights and implications for bacterial identification [0.03%]
细菌蛋白质组多样性及其在细菌鉴定中的应用和意义
Miriam Abele,Armin Soleymaniniya,Florian P Bayer et al.
Miriam Abele et al.
Mass spectrometry-based proteomics has revolutionized bacterial identification and elucidated many molecular mechanisms underlying bacterial growth, community formation, and drug resistance. However, most research has been focused on a few ...
Quantitative chromatin protein dynamics during replication origin firing in human cells [0.03%]
人类细胞中复制起始过程中染色质蛋白的定量动力学研究
Sampath Amitash Gadi,Ivo Alexander Hendriks,Christian Friberg Nielsen et al.
Sampath Amitash Gadi et al.
Accurate genome duplication requires a tightly regulated DNA replication program, which relies on the fine regulation of origin firing. While the molecular steps involved in origin firing have been determined predominantly in budding yeast,...
A Primer on Proteomic Characterization of Intercellular Communication in a Virus Microenvironment [0.03%]
病毒微环境中细胞间通讯的蛋白质组表征综述
James C Kostas,Colter S Brainard,Ileana M Cristea
James C Kostas
Intercellular communication is fundamental to multicellular life and a core determinant of outcomes during viral infection, where the common goals of virus and host for persistence and replication are generally at odds. Hosts rely on encode...