Embryo-Induced Changes in the Protein Profile of Bovine Oviductal Extracellular Vesicles [0.03%]
胚胎诱导牛输卵管细胞外囊泡蛋白谱的变化
Rosane Mazzarella,José María Sánchez,Beatriz Fernandez-Fuertes et al.
Rosane Mazzarella et al.
The study of early maternal-embryonic cross-talk remains one of the most challenging topics in reproductive biology. Understanding the physiological mechanisms involved in the interactions between the maternal reproductive tract and the dev...
Proteomic analysis of human follicular fluid-derived exosomes reveals that insufficient folliculogenesis in aging women is associated with infertility [0.03%]
人类卵泡液来源外泌体的蛋白质组学分析显示年龄较大女性卵泡发育不足与不孕有关
Zhen Liu,Qilin Zhou,Jun Zan et al.
Zhen Liu et al.
Although the risk of female infertility increases with advancing age, the underlying mechanisms remain unknown. Exosomes in follicular fluid are suggested to regulate folliculogenesis and influence oocyte quality, potentially playing a crit...
S E Orchard
S E Orchard
The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been successfully developing guidelines, data formats, and controlled vocabularies for both the field of molecular interaction and that of mass spectrometry fo...
Integrated multiomics reveals alterations in paucimannose and complex type N-glycans in cardiac tissue of COVID-19 patients [0.03%]
综合多组学揭示了COVID-19患者心脏组织中少甘露糖和复杂型N-连接聚糖的改变
Sabarinath Peruvemba Subramanian,Melinda Wojtkiewicz,Fang Yu et al.
Sabarinath Peruvemba Subramanian et al.
Coronavirus infectious disease 19 (COVID-19) can lead to cardiac complications, yet the molecular mechanisms driving these effects remain unclear. Protein glycosylation is crucial for viral replication, immune response, and organ function a...
Comprehensive Immunoglobulin G, A, and M glycopeptide profiling for large-scale biomedical research [0.03%]
大规模生物医学研究的全面免疫球蛋白G、A和M糖肽谱分析
Bianca D M van Tol,Anna M Wasynczuk,Steinar Gijze et al.
Bianca D M van Tol et al.
Glycosylation of immunoglobulin G (IgG) is recognized as a key modulator of cellular effector functions. At the same time, an increasing body of evidence underlines the importance of other antibody isotypes, especially IgA and IgM, in patho...
Arthur Grimaud,Masa Babovic,Frederik Haugaard Holck et al.
Arthur Grimaud et al.
Tandem mass spectrometry of peptides and proteins generates mass spectra of their gas-phase fragmentation product ions, including N-terminal, C-terminal, and internal fragment ions. Whereas N- and C-terminal ions are routinely assigned and ...
HEXB drives raised paucimannosylation in colorectal cancer and stratifies patient risk [0.03%]
HEXB驱动的少甘露糖基化在结直肠癌中上调并分层患者风险
Rebeca Kawahara,Liisa Kautto,Naaz Bansal et al.
Rebeca Kawahara et al.
Non-invasive prognostic markers are needed to improve the survival of colorectal cancer (CRC) patients. Towards this goal, we applied untargeted systems glycobiology approaches to snap frozen and formalin-fixed paraffin-embedded tumor tissu...
Identifying receptor kinase substrates using an 8,000 peptide kinase client library enriched for conserved phosphorylation sites [0.03%]
利用富含保守磷酸化位点的8000肽受体激酶底物文库识别受体激酶底物
Daewon Kim,Gabriel Lemes Jorge,Chunhui Xu et al.
Daewon Kim et al.
In eukaryotic organisms, protein kinases regulate diverse protein activities and signaling pathways through phosphorylation of specific protein substrates. Isolating and characterizing kinase substrates is vital for defining downstream sign...
Glycoproteoforms of osteoarthritis-associated lubricin in plasma and synovial fluid [0.03%]
滑膜液和血浆中的润滑素糖蛋白-Proteoform及其与骨关节炎的关系
Ali Reza Afshari,Vincent Chang,Kristina A Thomsson et al.
Ali Reza Afshari et al.
Lubricin/proteoglycan-4 (PRG-4) is a mucinous glycoprotein that lubricates cartilage and maintains normal tissue function and cell homeostasis. Altered O-glycoproteforms of lubricin have been found in osteoarthritis (OA) synovial fluid (SF)...
Fan Zhang,Yunzhi Wang,Jiajun Zhu et al.
Fan Zhang et al.
The heart is a vital muscular organ in vertebrate animals, responsible for maintaining blood circulation through rhythmic contraction. Although previous studies have investigated the heart proteome, the full hierarchical molecular network a...