Blinatumomab versus chemotherapy in pediatric B-ALL: A meta-analysis of randomized trials in relapsed and high-risk frontline disease [0.03%]
儿科B细胞急性淋巴细胞白血病复发和高危初诊患者中Blina单抗与化疗的对比：随机试验Meta分析
Adeena Musheer,Muhammad Shaheer Mannan,Muhammad Waqas Khan et al.
Adeena Musheer et al.
Background: B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric cancer, comprising almost 25 % of childhood malignancies. Despite advances in chemotherapy, relapse remains a major cause of treatment f...
Multicenter retrospective study on the clinical profiles of patients with extensive-stage small-cell lung cancer who met the eligibility criteria for clinical trials [0.03%]
多中心回顾性分析广泛期小细胞肺癌临床试验合格患者的临床特征
Tatsuya Yazaki,Kei Sonehara,Toshiharu Tsutsui et al.
Tatsuya Yazaki et al.
Background: Chemoimmunotherapy is the standard first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC); however, a limited number of real-world cases meet the inclusion and exclusion criteria of clinical...
BATPC: A biology-anchored tumor progression classification for interpreting multidimensional progression phenotypes across solid tumors [0.03%]
基于生物学的肿瘤进展分类：解释实体瘤多维度进展表型
Yogesh Kumar Gupta
Yogesh Kumar Gupta
Background: Conventional size-based criteria such as RECIST collapse biologically diverse progression patterns into a single "progressive disease" label, obscuring clinically meaningful heterogeneity. As multimodal monito...
Predictors of pathological upgrading in low-risk gleason grade group 1 prostate cancer on prostate biopsy: the role of clinical and tumor-specific factors [0.03%]
低危Gleason 1组前列腺癌患者病理恶变的预测因素：临床及肿瘤特异性因素的作用
Shirin Razdan,Ali Fathollahi,Alexandre Armache et al.
Shirin Razdan et al.
Objective: Gleason Grade Group (GG) 1 prostate cancer (PCa) with PSA 8.1%, presence of atypical small acinar proliferation (ASAP) or intraductal carcinoma (IDC) on biopsy. ...
Genomic risk distribution, adjuvant chemotherapy trends, and survival outcomes in women with pT1, grade 1-2, ER/PR-positive, LVI-negative breast cancer [0.03%]
pT1期、Grade 1-2、ER/PR阳性、LVI阴性乳腺癌患者的基因组风险分布、辅助化疗趋势和生存结局
Nickolas Stabellini,Maya Lubarsky,Ananya Munjal et al.
Nickolas Stabellini et al.
Background: Oncotype DX Recurrence Score (RS) guides adjuvant chemotherapy decisions in early-stage hormone receptor-positive (HR+), HER2-negative breast cancer (BC). However, the survival benefit of adjuvant chemotherapy...
Morgan Terry,Alex Lichtl,Peiran Zhou et al.
Morgan Terry et al.
Head and neck squamous cell carcinoma (HNSCC) is a pathology that necessitates collaborative care and multidisciplinary management. There is a role for timely surgical involvement which evolves at different stages of disease progression. Up...
Clinical impact of a single time-point protocol paired FDG-PET and radioactive iodine scan for comprehensive disease assessment in differentiated thyroid cancer [0.03%]
一次显像配对18F-FDG PET和放射性碘扫描全面评估分化型甲状腺癌病情的临床价值
Margaret Locke,Charit Taneja,Mehdi Djekidel et al.
Margaret Locke et al.
Background: Treatment decisions in advanced or metastatic differentiated thyroid cancer require comprehensive clinical, genomic, and imaging evaluations. FDG-PET and radioactive iodine (RAI) scans image different biologic...
Patterns of care for older multiple myeloma patients in the U.S.: An analysis of the national cancer database [0.03%]
美国老年人多重骨髓瘤治疗模式的分析：基于国家癌症数据库的研究
Muni Rubens,Jeremy Purow,Daniel M Portnoy et al.
Muni Rubens et al.
This study highlights the vital role of personalized treatment strategies in managing multiple myeloma (MM) among older patients, a population greatly affected by this disease. We conducted a retrospective analysis using data from the Natio...
Too late to fall: Time to PSA nadir and early oncologic failure after cryotherapy and high-intensity focused ultrasound for localized prostate cancer [0.03%]
前列腺癌患者经cryotherapy和高强度聚焦超声治疗后PSA最低值的时间及早期肿瘤失败的多变量分析
Umberto Anceschi,Salvatore Basile,Leonardo Misuraca et al.
Umberto Anceschi et al.
Introduction: The ability of time to PSA nadir (TTN) to predict early treatment failure after focal therapy for prostate cancer remains unclear. We assessed whether TTN and PSA nadir-related parameters are associated with...
Artificial intelligence, omics, and biomarkers: Redefining lung cancer early detection [0.03%]
人工智能、组学和生物标志物：重新定义肺癌早期检测
Anam Nizam,Nawal Shireen,Mohd Rahil Hasan et al.
Anam Nizam et al.
Lung cancer, the leading cause of death worldwide, claims millions of lives yearly, largely due to limited early interventions. Currently used lung cancer screening methods are still limited in their reach and accuracy due to invasiveness, ...