Fibroblast Activation Protein-Targeted Radiopharmaceutical Therapy Using 177Lu-, 90Y-, and 225Ac-Labeled 3BP-3940: First Experience in 21 Different Advanced Malignancies [0.03%]
应用177Lu-, 90Y-和225Ac标记的3BP-394针对成纤维活化蛋白的放射性药物治疗：在21种不同晚期恶性肿瘤中的首次经验
Richard P Baum,Tianzhi Zhao,Vivianne Jakobsson et al.
Richard P Baum et al.
Fibroblast activation protein (FAP) is an attractive target for molecular precision imaging and therapy, given its specific tumor expression across various cancer types. We report first-in-human results using a FAP-targeted cyclic peptide, ...
Jean-Luc C Urbain
Jean-Luc C Urbain
Industry-Academic Collaboration in Nuclear Medicine: Proceedings from the 2024 CMIIT Industry Partners Circle [0.03%]
核医学产学研合作：2024年CMIIT产业伙伴圆桌论坛 proceedings
Dustin Osborne,Cathy S Cutler,Ivis F Chaple et al.
Dustin Osborne et al.
Advancing and streamlining the development pipeline and translation of theranostic radiopharmaceuticals for application in nuclear medicine necessitates continued cross-sector collaboration among key stakeholders from the Society of Nuclear...
Toward Personalized Radiopharmaceutical Therapy: Radiobiologic Insights Compared with External-Beam Radiotherapy [0.03%]
朝向个性化放射药物治疗：与外照射放疗相比的放射生物学见解
Sébastien Penninckx,Wendy Delbart,Magdalena Mileva et al.
Sébastien Penninckx et al.
Radiopharmaceutical therapy differs from external-beam radiation therapy through systemic delivery, a heterogeneous dose distribution, and a low dose rate, challenging conventional radiobiology and dose-effect relationships. These features ...
First-in-Human Imaging Results of PHAROS: A Versatile High-Resolution TOF/DOI PET Scanner for Brain, Breast, and Extremity Imaging [0.03%]
PHAROS首个人体影像结果：一种多功能高分辨率TOF/DOI PET脑、乳腺和四肢成像仪
Guen Bae Ko,Kyeong Yun Kim,Seung Kwan Kang et al.
Guen Bae Ko et al.
We present the design and performance of the newly developed PHAROS-a high-resolution, multifunctional PET system integrating time-of-flight (TOF) and depth-of-interaction (DOI) technologies-and report its first-in-human imaging results for...
Utility of Preclinical Dosimetry for First-in-Human Studies with PET Drugs Labeled with Common Radionuclides: A Systematic Review of Radiation Dose Estimates [0.03%]
小动物放射剂量学在PET药物首次用于临床研究中的作用：系统性文献回顾
Hayoung Koo,Donika Plyku,Libero Marzella
Hayoung Koo
First-in-human studies of radiopharmaceuticals include an estimation of human radiation doses often extrapolated from preclinical biodistribution data. We reviewed radiation dose estimates derived from preclinical and clinical studies to de...
A Call for High-Level Evidence Before Routine Implementation of Posttreatment SPECT [0.03%]
呼吁在常规实施术后SPECT之前需要高质量的证据
Philipose G Mulugeta,Sophia R O&#x;Brien,David A Mankoff et al.
Philipose G Mulugeta et al.
Assessing Value for Money in Theranostic Nuclear Medicine: A Systematic Review [0.03%]
治疗诊断核医学的价值评估：系统性综述
Yufan Wang,James L Wood,Kristofer J Thurecht et al.
Yufan Wang et al.
Radiotheranostic therapy (RTT) is an emerging form of personalized cancer care that combines radiopharmaceutical imaging and radiopharmaceutical therapy (RPT). Although promising clinically, the value for money of RTT remains uncertain. The...
Salvage Radiotherapy Confers an Overall Survival Advantage in Biochemical Recurrence of Prostate Cancer: Evidence from the International PROMISE Registry [0.03%]
国际PROMISE注册研究显示：生化复发前列腺癌挽救放疗可提高总生存率
Nika Guberina,Madeleine J Karpinski,Maja Guberina et al.
Nika Guberina et al.
The impact of salvage radiotherapy (SRT) on overall survival (OS) in patients experiencing biochemical recurrence (BCR) of prostate cancer remains an area of active investigation. The international multicenter PROMISE registry provides a va...
Preoperative Assessment of Peritoneal Carcinomatosis with [68Ga]Ga-FAPI-46 PET/CT: Agreement with Surgicopathologic PCI and Comparison with MRI and [18F]FDG PET/CT [0.03%]
68Ga-FAPI-46 PET/CT在腹膜癌转移的术前评估中的价值：与病理PCI评分、MRI和18F-FDG PET/CT对比研究
Ayça Arçay Öztürk,Gabriel Liberale,Anne-Leen Deleu et al.
Ayça Arçay Öztürk et al.
Accurate preoperative mapping of peritoneal carcinomatosis (PC) is critical for selecting patients for cytoreductive surgery and guiding treatment planning. Conventional imaging, including [18F]FDG PET/CT (FDG PET), may underestimate PC ext...