SSTR-Targeted Radiotheranostics in Breast Cancer: A Comparison of [68Ga]Ga-DOTATOC and [68Ga]Ga-SSO120 with [18F]FDG PET [0.03%]
乳腺癌中的SSTR靶向放射治疗诊断：[68Ga]Ga-DOTATOC和[68Ga]Ga-SSO120与[18F]FDG PET的比较
Alina T Küper,Lalith Kumar Shiyam Sundar,Loíc Djaileb et al.
Alina T Küper et al.
Somatostatin receptor (SSTR)-targeting radiotracers hold promise for theranostic applications in breast cancer (BC). This retrospective single-center study aimed to assess the proportion of SSTR-positive BC and its relevance for peptide rec...
Prognostic Value of Restaging [18F]FDG PET/CT in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [177Lu]Lu-PSMA-617 Therapy [0.03%]
[177Lu]Lu-PSMA-617治疗转移性去势抵抗性前列腺癌患者中重分期[18F]FDG PET/CT的预后价值
Raghava Kashyap,James P Buteau,Nathan Papa et al.
Raghava Kashyap et al.
We analyzed the prognostic value of an interim [18F]FDG PET/CT performed after cycle 3 of [177Lu]Lu-PSMA-617 ([177Lu]Lu-PSMA) for patients undergoing therapy for metastatic castration-resistant prostate cancer (mCRPC). Methods: We retrospec...
Radiation-Induced Senescence in Radiopharmaceutical Therapy: Mechanisms and Therapeutic Implications [0.03%]
放射性药物治疗中的辐射诱导衰老：机制和治疗意义
Marcus J Lindsey,Reinier Hernandez
Marcus J Lindsey
Radiopharmaceutical therapy (RPT) has emerged as a radiation therapy modality with the distinctive ability to systemically treat metastatic disease by targeting specific biologic features expressed on cancer cells. Although the radiobiology...
Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of a S. aureus-Targeted 18F-Disaccharide [0.03%]
一种耐热尼日糖磷酸化酶高效合成抗金黄色葡萄球菌同位素标记双糖的放射化学法
Jung Min Kim,Sang Hee Lee,Shari Dhaene et al.
Jung Min Kim et al.
Staphylococcus aureus is a leading cause of life-threatening infections worldwide. The diagnosis and treatment of S. aureus infections are further complicated by the global rise of antimicrobial resistance. Therefore, rapid detection of act...
End-to-End PET/CT Interpretation and Quantification with an LLM-Orchestrated AI Agent: A Real-World Pilot Study [0.03%]
基于LLM编排的AI代理的端到端PET/CT解释和量化：一项真实世界试点研究
Hongyoon Choi,Sungwoo Bae,Kwon Joong Na
Hongyoon Choi
Although deep learning models have improved individual PET analysis, image processing, and quantification tasks, end-to-end automation from raw DICOM data to quantitative clinical reporting remains limited, particularly in heterogeneous rea...
Renal Medullary Carcinoma: Utility of [18F]FDG PET/CT in Evaluating Extent of Disease and Impact on Treatment Management [0.03%]
18F-FDG PET/CT在肾髓质癌判断疾病分期和影响治疗决策中的作用
Simone Krebs,Ahmed E Salem,Nghi C Nguyen et al.
Simone Krebs et al.
The value of [18F]FDG PET/CT imaging in the management of SMARCB1-deficient renal medullary carcinoma (RMC), a rare and aggressive type of kidney cancer, has not been established. We sought to determine the utility of [18F]FDG PET/CT findin...
Imaging xCT with Immuno-PET in Therapy-Resistant Non-Small Cell Lung Cancer [0.03%]
治疗抵抗性非小细胞肺癌中使用免疫PET成像xCT
Abigail R Barber,Richard S Edwards,Sofia N Dos Santos et al.
Abigail R Barber et al.
Therapy resistance presents a major clinical challenge in non-small cell lung cancer (NSCLC), contributing to its high mortality rate. Overexpression of the amino acid transporter xCT frequently mediates treatment resistance in NSCLC and ca...
Revisiting Perfusion in the Forgotten Right Ventricle: Artificial Intelligence-Enhanced Quantification on PET/CT [0.03%]
重温被遗忘的右心室的灌注：PET/CT上的人工智能增强定量分析
Aakash Shanbhag,Robert J H Miller,Paul Kavanagh et al.
Aakash Shanbhag et al.
Increased right ventricular (RV) radiotracer uptake on perfusion imaging has been recognized as a marker of increased cardiovascular risk. However, this uptake is challenging to quantify because of the variable intensity of uptake in a thin...
Molecular Imaging of Mechanisms of Impaired Cardiac Repair After Macrophage Depletion in Mice: A Longitudinal Multitracer Imaging Study [0.03%]
小鼠心脏巨噬细胞耗竭后的心肌修复机制的分子成像研究：一项纵向多示踪剂成像研究
Annika Hess,Maja Strunk,Michael Willmann et al.
Annika Hess et al.
Macrophage depletion before myocardial infarction (MI) in mice disrupts the inflammatory healing response and leads to left ventricular thrombus formation and tissue calcification. Here, we aimed to determine the effect of clodronate-loaded...
PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [68Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy [0.03%]
PI-RADS 4和5病变的PCa检测：[68Ga]Ga-PSMA-11 PET/CT引导的机器人辅助活检与mpMRI认知融合超声引导前列腺活检对比研究
Rajender Kumar,Aravindh Ram,Santosh Kumar et al.
Rajender Kumar et al.
Lesions with a Prostate Imaging-Reporting and Data System (PI-RADS) score of 4 or greater on multiparametric MRI (mpMRI) indicate a high likelihood of prostate cancer (PCa), and guidelines recommend a targeted biopsy. We aimed to compare th...