Noninvasive PET Detection of CD69-Positive Immune Cells Before Signs of Clinical Disease in Inflammatory Arthritis [0.03%]
无创正电子发射断层显像检测关节炎临床症状出现前CD69阳性免疫细胞的存在
Emmi Puuvuori,Yunbing Shen,Gry Hulsart-Billström et al.
Emmi Puuvuori et al.
Rheumatoid arthritis (RA) is the most common inflammatory joint disease, and early diagnosis is key for effective disease management. CD69 is one of the earliest cell surface markers seen at the surface of activated immune cells, and CD69 i...
Imaging PARP Upregulation with [123I]I-PARPi SPECT/CT in Small Cell Neuroendocrine Carcinoma [0.03%]
使用[123I]I-PARPi SPECT/CT成像小细胞神经内分泌癌中的PARP上调
Honest Ndlovu,Ismaheel Lawal,Kgomotso Mokoala et al.
Honest Ndlovu et al.
MRI or 18F-FDG PET for Brain Age Gap Estimation: Links to Cognition, Pathology, and Alzheimer Disease Progression [0.03%]
磁共振成像或18F-FDG正电子发射断层显像在脑龄差距评估中的应用：与认知、病理和阿尔茨海默病进展的关系
Elena Doering,Georgios Antonopoulos,Merle Hoenig et al.
Elena Doering et al.
Deviations of brain age from chronologic age, known as the brain age gap (BAG), have been linked to neurodegenerative diseases such as Alzheimer disease (AD). Here, we compare the associations of MRI-derived (atrophy) or 18F-FDG PET-derived...
Preclinical Development of PNT6555, a Boronic Acid-Based, Fibroblast Activation Protein-α (FAP)-Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors [0.03%]
基于硼酸的成纤维细胞活化蛋白-α(PNT6555)放射治疗诊断剂的临床前开发，用于成纤维细胞活化蛋白阳性肿瘤的成像和治疗
Sarah E Poplawski,Robin M Hallett,Mark H Dornan et al.
Sarah E Poplawski et al.
The overexpression of fibroblast activation protein-α (FAP) in solid cancers relative to levels in normal tissues has led to its recognition as a target for delivering agents directly to tumors. Radiolabeled quinoline-based FAP ligands hav...
Automated Motion Correction for Myocardial Blood Flow Measurements and Diagnostic Performance of 82Rb PET Myocardial Perfusion Imaging [0.03%]
心肌血流测量的自动运动校正及82rubidium pet心肌灌注成像的诊断性能
Keiichiro Kuronuma,Chih-Chun Wei,Ananya Singh et al.
Keiichiro Kuronuma et al.
Motion correction (MC) affects myocardial blood flow (MBF) measurements in 82Rb PET myocardial perfusion imaging (MPI); however, frame-by-frame manual MC of dynamic frames is time-consuming. This study aims to develop an automated MC algori...
Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein α [0.03%]
用于活化蛋白α的放射性诊疗单域抗体的临床前评估
Yana Dekempeneer,Sam Massa,Francis Santens et al.
Yana Dekempeneer et al.
Fibroblast activation protein α (FAP) is highly expressed on cancer-associated fibroblasts of epithelial-derived cancers. Breast, colon, and pancreatic tumors often show strong desmoplastic reactions, which result in a dominant presence of...
Unraveling the Impact of 177Lu-PSMA Radioligand Therapy on Renal Impairment: Distinguishing Causation from Correlation [0.03%]
揭开177Lu-PSMA放射配体治疗对肾功能损害的影响：区分因果关系与相关性
Aravind S Ravi Kumar,Michael S Hofman
Aravind S Ravi Kumar
Noninvasive Monitoring of Immunotherapy in Lung Cancer by Lymphocyte Activation Gene 3 PET Imaging of Tumor-Infiltrating Lymphocytes [0.03%]
利用淋巴细胞活化基因3正电子发射断层扫描成像非侵入性监测肺癌免疫治疗中肿瘤浸润的淋巴细胞
Zhen Quan,Zhaoguo Han,Yang Yang et al.
Zhen Quan et al.
Although immunotherapy has revolutionized the entire cancer treatment landscape, small fractions of patients respond to immunotherapy. Early identification of responders may improve patient management during immunotherapy. In this study, we...
68Ga-Labeled Fibroblast Activation Protein Inhibitor (68Ga-FAPI) PET for Pancreatic Adenocarcinoma: Data from the 68Ga-FAPI PET Observational Trial [0.03%]
68镓标记的成纤维细胞活化蛋白抑制剂(68Ga-FAPI) PET在胰腺癌中的应用：来自68Ga-FAPI PET观察性试验的数据
Lukas Kessler,Nader Hirmas,Kim M Pabst et al.
Lukas Kessler et al.
The fibroblast activation protein (FAP) is highly expressed on carcinoma-associated fibroblasts in the stroma of pancreatic cancer and thus is a promising target for imaging and therapy. Preliminary data on PET imaging with radiolabeled FAP...