Eric Shin,Mark Chen,Shiva Daram et al.
Eric Shin et al.
Amphiphilic block copolymers are finding increased potential in biological and medical research due to their innate alternating hydrophilic and hydrophilic blocks/segments which can be used to package therapeutics, or coat a broad array of ...
Microengineering hydrogels for stem cell bioengineering and tissue regeneration [0.03%]
用于干细胞生物工程和组织再生的微工程水凝胶
Ian Wheeldon,Amirhossein F Ahari,Ali Khademhosseini
Ian Wheeldon
The integration of microfabrication technologies with advanced biomaterials has led to the development of powerful tools to control the cellular microenvironment and the microarchitecture of engineered tissue constructs. Here we review this...
Wei Xu,Nicholas E Manicke,Graham R Cooks et al.
Wei Xu et al.
The key concepts and technologies developed in our laboratories in Purdue University for the miniaturization of mass spectrometry analysis systems are introduced. Mass analyzers of simple geometries with a novel atmospheric pressure interfa...
Microvalve Enabled Digital Microfluidic Systems for High Performance Biochemical and Genetic Analysis [0.03%]
一种新型微阀数字化微流控系统实现高效生物及基因分析
Erik C Jensen,Yong Zeng,Jungkyu Kim et al.
Erik C Jensen et al.
Microfluidic devices offer unparalleled capability for digital microfluidic automation of sample processing and complex assay protocols in medical diagnostic and research applications. In our own work, monolithic membrane valves have enable...
Electrothermal Fluid Manipulation of High-Conductivity Samples for Laboratory Automation Applications [0.03%]
高导电样品的电热流体操控在实验室自动化中的应用
Mandy L Y Sin,Vincent Gau,Joseph C Liao et al.
Mandy L Y Sin et al.
Electrothermal flow is a promising technique in microfluidic manipulation toward laboratory automation applications, such as clinical diagnostics and high throughput drug screening. Despite the potential of electrothermal flow in biomedical...
Merging Microfluidics with Micro-titre Technology for More Efficient Drug Discovery [0.03%]
微流体技术结合微孔板技术实现更有效的药物筛选
Nicole V Tolan,Luiza I Genes,Dana M Spence
Nicole V Tolan
Detecting multiple components from a single red blood cell (RBC) sample within a flow-based system and in less than 20 minutes will enable improved in vitro determinations of drug efficacy and cellular response to administered drugs. Here, ...
A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates [0.03%]
一种利用光子晶体制备的生物传感器微孔板鉴定小分子聚集物的方法
Leo L Chan,Erich A Lidstone,Kristin E Finch et al.
Leo L Chan et al.
Small molecules identified through high-throughput screens are an essential element in pharmaceutical discovery programs. It is now recognized that a substantial fraction of small molecules exhibit aggregating behavior leading to false posi...
David J Cappelleri,Adam Halasz,Jai-Yoon Sul et al.
David J Cappelleri et al.
We have designed and implemented a framework for creating a fully automated high-throughput phototransfection system. Integrated image processing, laser target position calculation, and stage movements show a throughput increase of > 23X ov...
Detection of Non-Nucleic Acid Targets with an Unmodified Aptamer and a Fluorogenic Competitor [0.03%]
利用未改性的适配体和荧光竞争探针检测非核酸靶标
Na Li
Na Li
Aptamers are oligonucleotides that can bind to various non-nucleic acid targets, ranging from proteins to small molecules, with a specificity and affinity comparable to that of antibodies. Most aptamer-based detection strategies require mod...
Weichun Yang,Adam T Woolley
Weichun Yang
Microfluidic technologies have been applied extensively in rapid sample analysis. Some current challenges for standard microfluidic systems are relatively high detection limits, and reduced resolving power and peak capacity compared to conv...