Laszlo Farkas
Laszlo Farkas
Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and Fibrosis [0.03%]
癌症代谢对肺动脉高压和纤维化的启示
SeungHye Han,Navdeep S Chandel
SeungHye Han
Metabolism is essential for a living organism to sustain life. It provides energy to a cell by breaking down compounds (catabolism) and supplies building blocks for the synthesis of macromolecules (anabolism). Signal transduction pathways t...
Kenichi Okuda,Scott H Randell,Susan E Birket
Kenichi Okuda
Scavenger Hunt: SR-B1, Adrenal Insufficiency, IL-17A, and Neutrophilic Airway Inflammation in Asthma [0.03%]
寻踪索隐SR-B1：肾上腺皮质功能不全、IL-17A与哮喘中性粒细胞气道炎症之间的关联
Xianglan Yao,Stewart J Levine
Xianglan Yao
A Translational Investigation of IFN-α and STAT1 Signaling in Endothelial Cells during Septic Shock Provides Therapeutic Perspectives [0.03%]
对内皮细胞在感染性休克期间干扰素-α和信号转导和转录激活因子1（STAT1）信号传导的转化研究提供了治疗见解
Raphaël Clere-Jehl,Hamid Merdji,Mohamad Kassem et al.
Raphaël Clere-Jehl et al.
Septic shock and disseminated intravascular coagulation (DIC) are known to be characterized by an endothelial cell dysfunction. The molecular mechanisms underlying this relationship are, however, poorly understood. In this work, we aimed to...
The Role of Obesity in the Immunopathogenesis of COVID-19 Respiratory Disease and Critical Illness [0.03%]
肥胖在COVID-19呼吸系统疾病免疫发病机制中的作用
Stephen J Kuperberg,Brianne Navetta-Modrov
Stephen J Kuperberg
Coronavirus disease (COVID-19), the clinical syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a global health pandemic with substantial morbidity and mortality. COVID-19 has cast a shadow on near...
Human Primary Airway Basal Cells Display a Continuum of Molecular Phases from Health to Disease in Chronic Obstructive Pulmonary Disease [0.03%]
慢性阻塞性肺疾病中气道基底细胞分子特征从健康到疾病的连续性转变
Sofia C Wijk,Pavan Prabhala,Barbora Michaliková et al.
Sofia C Wijk et al.
Airway basal cells are crucial for regeneration of the human lung airway epithelium and are believed to be important contributors to chronic obstructive pulmonary disease (COPD) and other lung disorders. To reveal how basal cells contribute...
V-Type ATPase Mediates Airway Surface Liquid Acidification in Pig Small Airway Epithelial Cells [0.03%]
猪小气道上皮细胞气道表面液体酸化介导需要V-ATP酶
Xiaopeng Li,Raul Villacreses,Ian M Thornell et al.
Xiaopeng Li et al.
In a newborn pig cystic fibrosis (CF) model, the ability of gland-containing airways to fight infection was affected by at least two major host-defense defects: impaired mucociliary transport and a lower airway surface liquid (ASL) pH. In t...