SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema [0.03%]
SDH辅基C亚基调节肺气肿动物模型中的肌肉耗氧量和疲劳度
Joseph Balnis,Lisa A Drake,Catherine E Vincent et al.
Joseph Balnis et al.
Patients with pulmonary emphysema often develop locomotor muscle dysfunction, which is independently associated with disability and higher mortality in that population. Muscle dysfunction entails reduced force generation capacity, which par...
Leptin Induces Epigenetic Regulation of Transient Receptor Potential Melastatin 7 in Rat Adrenal Pheochromocytoma Cells [0.03%]
瘦素通过表观遗传学机制调节肾上腺嗜铬细胞瘤细胞中瞬时受体电位锚蛋白1通道蛋白的表达
Bonnie Ho-Yee Yeung,Kelly Griffiths,Liron Berger et al.
Bonnie Ho-Yee Yeung et al.
Obesity elevates the plasma level of leptin, which has been associated with hypertension. Our recent studies in mice demonstrated that leptin increases blood pressure by activating the carotid sinus nerve, which transmits the chemosensory i...
Impaired Differentiation of Chronic Obstructive Pulmonary Disease Bronchial Epithelial Cells Grown on Bronchial Scaffolds [0.03%]
气道支架上慢阻肺支气管上皮细胞的分化缺陷
Ulf Hedström,Lisa Öberg,Outi Vaarala et al.
Ulf Hedström et al.
Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, small airway remodeling, and emphysema. Airway remodeling in patients with COPD involves both the airway epithelium and the subepithelial extracellular ma...
Clioquinol Attenuates Pulmonary Fibrosis through Inactivation of Fibroblasts via Iron Chelation [0.03%]
氯喹酮通过铁螯合作用抑制成纤维细胞活性从而缓解肺纤维化
Yumeng Zhu,Jing Chang,Ke Tan et al.
Yumeng Zhu et al.
Strict control of iron homeostasis is critical for the maintenance of normal lung function. Iron accumulates in the lungs of patients with idiopathic pulmonary fibrosis (PF), but the characteristics of iron metabolism in the pathogenesis of...
Bronchopulmonary Dysplasia: Endothelial Cells in the Driver's Seat [0.03%]
bronchopulmonary dysplasia：血管内皮细胞发挥主导作用
Christine U Vohwinkel,Rubin M Tuder
Christine U Vohwinkel
Airway Basal Cells in Chronic Obstructive Pulmonary Disease: A Continuum or a Dead End? [0.03%]
慢性阻塞性肺疾病中的气道基底细胞：连续谱系还是死胡同？
Renat Shaykhiev
Renat Shaykhiev
Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis [0.03%]
囊性纤维化中炎性小体基因变异、巨噬细胞功能和临床结局
Andrew D Graustein,William R Berrington,Kati J Buckingham et al.
Andrew D Graustein et al.
Cystic fibrosis (CF) is characterized by chronic airway infection, inflammation, and tissue damage that lead to progressive respiratory failure. NLRP3 and NLRC4 are cytoplasmic pattern recognition receptors that activate the inflammasome, i...
Erin N Yepsen,Kevin S Harrod
Erin N Yepsen
TREM2 Dictates Antibacterial Defense and Viability of Bone Marrow-derived Macrophages during Bacterial Infection [0.03%]
TREM2调控骨髓来源巨噬细胞在细菌感染中的抗菌免疫和细胞存活
ShiYue Yang,Yang Yang,FeiFei Wang et al.
ShiYue Yang et al.
Macrophages undergo profound metabolic reprogramming to join key immunoregulatory functions, which can be initiated by pattern recognition receptors. TREM2 (triggering receptor expressed on myeloid cells 2), a macrophage phagocytic receptor...
Kindlin for the Fire: Targeting Proline Synthesis to Extinguish Matrix Production in Pulmonary Fibrosis [0.03%]
肺纤维化中针对脯氨酸合成以熄灭细胞外基质生成的研究
Robert Guzy,Elizabeth F Redente
Robert Guzy