ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1 [0.03%]
ZMPSTE24调节SARS-CoV-2刺突蛋白增强内皮PAI-1的表达
Mingming Han,Deepesh Pandey
Mingming Han
Endothelial dysfunction is implicated in the thrombotic events reported in patients with coronavirus disease (COVID-19), but the underlying molecular mechanisms are unknown. Circulating levels of the coagulation cascade activator PAI-1 are ...
TLR7 Agonist Suppresses Group 2 Innate Lymphoid Cell-mediated Inflammation via IL-27-Producing Interstitial Macrophages [0.03%]
TLR7激动剂通过产生IL-27的间质巨噬细胞抑制2型固有淋巴样细胞介导的炎症反应
Shinichi Okuzumi,Jun Miyata,Hiroki Kabata et al.
Shinichi Okuzumi et al.
Group 2 innate lymphoid cells (ILC2s) play an important role in the pathophysiology of asthma via the robust production of type 2 cytokines. Recent studies have demonstrated that TLR7 (Toll-like receptor 7) signaling skews toward a type 1 i...
Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease [0.03%]
小鼠非酒精性脂肪肝病中肝细胞缺氧诱导因子-1和间歇低氧独立影响肝纤维化
Omar A Mesarwi,Esteban A Moya,Xin Zhen et al.
Omar A Mesarwi et al.
Obstructive sleep apnea is associated with insulin resistance, lipid dysregulation, and hepatic steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD). We have previously shown that hepatocyte HIF-1 (hypoxia-inducible factor-1) ...
Current Smoking Alters Gene Expression and DNA Methylation in the Nasal Epithelium of Patients with Asthma [0.03%]
吸烟会改变哮喘患者鼻上皮的基因表达和DNA甲基化水平
Karosham D Reddy,Andy Lan,Ilse M Boudewijn et al.
Karosham D Reddy et al.
Current smoking contributes to worsened asthma prognosis and more severe symptoms and limits the beneficial effects of corticosteroids. As the nasal epithelium can reflect smoking-induced changes in the lower airways, it is a relevant sourc...
SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy [0.03%]
SARS-CoV-2感染与人体肺组织Krüppel样因子2降低有关
David Wu,Tzu-Han Lee,Ru-Ting Huang et al.
David Wu et al.
Nur77 Attenuates Inflammasome Activation by Inhibiting Caspase-1 Expression in Pulmonary Vascular Endothelial Cells [0.03%]
Nur77通过抑制胞浆内Caspase-1表达抑制肺血管内皮细胞中炎性小体的活化
Ru Ding,Xiaobo Sun,Bing Yi et al.
Ru Ding et al.
Inflammasomes are intracellular multiprotein complexes that help trigger and maintain the inflammatory response as part of the innate immune system. Recently, it has been increasingly recognized that aberrant inflammasome activation is crit...
Alexandra C Brown,Jay C Horvat
Alexandra C Brown
Functional Gene Variants in Chronic Obstructive Pulmonary Disease: The Search Continues [0.03%]
慢性阻塞性肺疾病的功能基因变异：继续寻找中
Mario Acunzo,Patrick Nana-Sinkam
Mario Acunzo
Improving Right Ventricular Function by Increasing BMP Signaling with FK506 [0.03%]
FK506通过增加BMP信号改善右心室功能
Mario Boehm,Xuefei Tian,Md Khadem Ali et al.
Mario Boehm et al.
Right ventricular (RV) function is the predominant determinant of survival in patients with pulmonary arterial hypertension (PAH). In preclinical models, pharmacological activation of BMP (bone morphogenetic protein) signaling with FK506 (t...
Martin Langelage,Julian Better,Michael Wetstein et al.
Martin Langelage et al.