Vitamin D Deficiency in Development: How Much Is Enough, and How Much Is Too Much? [0.03%]
维生素D缺乏与发育：多少才是足够的？多少才是过多的？
Erica W Mandell
Erica W Mandell
Greater Than the Sum of Its Parts: Integrating Multiple Data Sets to Decipher Cigarette Smoking Effects on Airway Epithelium [0.03%]
超越部分之和：整合多个数据集以解码吸烟对气道上皮的影响
Rachel L Clifford,Meaghan J Jones
Rachel L Clifford
Victoria A Ptasinski,John Stegmayr,Maria G Belvisi et al.
Victoria A Ptasinski et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injuries in the distal lung, which are followed by abnorma...
Basement Membrane Extracellular Matrix Proteins in Pulmonary Vascular and Right Ventricular Remodeling in Pulmonary Hypertension [0.03%]
肺动脉高压患者的肺血管和右心室重建中的基底膜细胞外基质蛋白表达
Anjira S Ambade,Paul M Hassoun,Rachel L Damico
Anjira S Ambade
The extracellular matrix (ECM), a highly organized network of structural and nonstructural proteins, plays a pivotal role in cellular and tissue homeostasis. Changes in the ECM are critical for normal tissue repair, whereas dysregulation co...
Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation [0.03%]
氧化固醇通过修改上皮细胞中的NLRP2介导的炎症介质，鉴定臭氧引起的炎症中介体
Alexia Perryman,Adam M Speen,Hye-Young H Kim et al.
Alexia Perryman et al.
Ozone (O3) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol A (SecoA), which are electrophiles that ar...
Effect of Perinatal Vitamin D Deficiency on Lung Mesenchymal Stem Cell Differentiation and Injury Repair Potential [0.03%]
围生期维生素D缺乏对肺间充质干细胞分化及损伤修复潜能的影响
Reiko Sakurai,Himanshu Singh,Ying Wang et al.
Reiko Sakurai et al.
Stem cells, including the resident lung mesenchymal stem cells (LMSCs), are critically important for injury repair. Compelling evidence links perinatal vitamin D (VD) deficiency to reactive airway disease; however, the effects of perinatal ...
Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis [0.03%]
非经典的Wnt信号促进肺纤维化中的肌成纤维细胞的分化
Tianju Liu,Francina Gonzalez De Los Santos,Mitchell Hirsch et al.
Tianju Liu et al.
The Wnt/β-catenin pathway initiates a signaling cascade that is critical in cell differentiation and the normal development of multiple organ systems. The reactivation of this pathway has been documented in experimental and human idiopathi...
Airway Administration of Flagellin Regulates the Inflammatory Response to Pseudomonas aeruginosa [0.03%]
鞭毛素的气道管理调节对铜绿假单胞菌的炎症反应
Raquel López-Gálvez,Isabelle Fleurot,Pablo Chamero et al.
Raquel López-Gálvez et al.
Excessive lung inflammation and airway epithelial damage are hallmarks of human inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity provides protection against pathogens while reducing lung-damaging infl...
Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters [0.03%]
携带ABCA3/SFTPC报告基因的人 iPSC 源性肺泡上皮II型细胞的异质性研究
Yuliang L Sun,Killian Hurley,Carlos Villacorta-Martin et al.
Yuliang L Sun et al.
Alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, are typically identified through the use of the canonical markers, SFTPC and ABCA3. Self-renewing AEC2-like cells have been generated from human induced ...
Sleep Apnea, Hypoxia Inducible Factor, and Fatty Liver: More Questions Than Answers? [0.03%]
阻塞性睡眠呼吸暂停、缺氧诱导因子与脂肪肝：更多问题待解？
Lenise J Kim,Luu V Pham,Vsevolod Y Polotsky
Lenise J Kim