Transcriptomic and Epigenetic Profiling of Fibroblasts in Idiopathic Pulmonary Fibrosis [0.03%]
特发性肺纤维化成纤维细胞的转录组和表观遗传谱分析
Ankit Hanmandlu,Lisha Zhu,Tinne C J Mertens et al.
Ankit Hanmandlu et al.
Idiopathic pulmonary fibrosis (IPF), a devastating, fibroproliferative, chronic lung disorder, is associated with expansion of fibroblasts/myofibroblasts, which leads to excessive production and deposition of extracellular matrix. IPF is ty...
Emel Baloğlu,Heimo Mairbäurl
Emel Baloğlu
Christian Martin
Christian Martin
Kazuhiro Ito
Kazuhiro Ito
Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis [0.03%]
内皮特异性鞘氨醇-1-磷酸受体1丢失增加血管通透性并加重博来霉素诱导的肺纤维化
Rachel S Knipe,Jillian J Spinney,Elizabeth A Abe et al.
Rachel S Knipe et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease which leads to significant morbidity and mortality from respiratory failure. The two drugs currently approved for clinical use slow the rate of decline in lung function b...
PINK1-mediated Mitophagy Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension [0.03%]
Pink1介导的线粒体自噬在肺动脉高压血管重塑中的作用研究
Alireza Saraji,Akylbek Sydykov,Katharina Schäfer et al.
Alireza Saraji et al.
Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases [0.03%]
内皮祖细胞在肺部疾病治疗中的潜力
Olena A Kolesnichenko,Jeffrey A Whitsett,Tanya V Kalin et al.
Olena A Kolesnichenko et al.
Compromised alveolar development and pulmonary vascular remodeling are hallmarks of pediatric lung diseases such as bronchopulmonary dysplasia (BPD) and alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). Although ad...
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling [0.03%]
二酰基甘油激酶抑制通过反向调节Gq信号减少气道收缩
Pawan Sharma,Santosh K Yadav,Sushrut D Shah et al.
Pawan Sharma et al.
Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors causes airway hyperresponsiveness in asthma. Activation of Gq-coupled G protein-coupled receptors leads to phospholipase C (PLC)-me...
Yan Y Sanders,Gang Liu
Yan Y Sanders