Interferon Mediated Bronchial Epithelium Cellular Senescence in Chronic Obstructive Pulmonary Disease [0.03%]
慢性阻塞性肺疾病介导的支气管上皮细胞衰老的影响因子
Hong Guo-Parke,Oisin Cappa,Dermot A Linden et al.
Hong Guo-Parke et al.
Cellular senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). The mechanisms of senescence in the bronchial epithelium, however, remain largely unknown. This study aimed to elucidate whether ce...
Targeted Pre-Conditioning and Cell Transplantation in the Murine Lower Respiratory Tract [0.03%]
针对小鼠下呼吸道的靶向预处理和细胞移植
Anat Kohn,Michael J Herriges,Payel Basak et al.
Anat Kohn et al.
Transplantation of airway basal stem cells could achieve a durable cure for genetic diseases of the airway, such as cystic fibrosis and primary ciliary dyskinesia. Recent work demonstrated the potential of primary- and pluripotent stem cell...
Extracellular Vesicles Contribute to the Pathophysiology and Progression of Pleural Fibrosis by Promoting MesoMT and Neo-Angiogenesis [0.03%]
外泌体通过促进间充质细胞转分化和新生血管生成参与胸膜纤维化病理生理过程及疾病进展
Kaushik Das,Wenyi Qin,Ann Jeffers et al.
Kaushik Das et al.
Severe pleural space inflammation associated with exudative pleural effusions leads to the development of pleural fibrosis (PF). Pathological tissue remodeling in PF is associated with profibrotic changes in the pleural mesothelium and neo-...
Piezo1 Agonist Yoda1 Induces Rapid Relaxation in Cultured Airway Smooth Muscle Cells and Bronchodilation in Mouse Models [0.03%]
Piezo1激动剂Yoda1可使培养的气道平滑肌细胞迅速松弛并使小鼠模型支气管扩张
Mingzhi Luo,Xiangrong Zhang,Jia Guo et al.
Mingzhi Luo et al.
Bronchodilators that relax airway smooth muscle cells (ASMCs) are essential for treating constrictive airway diseases such as asthma. However, the existing bronchodilators are often unable to control symptoms of severe asthmatic patients, l...
Atefeh Razazan,Md Habibul Hasan Mazumder,William Travis Goldsmith et al.
Atefeh Razazan et al.
Ozone (O3) is a criteria pollutant that is anticipated to rise over the next decade due to climate-related activity. Varying amounts of nitrogen oxides (NOx) are produced as by-products during O3 generation from oxygen depending on the meth...
Optimisation of DNA Extraction from Nasal Lining Fluid to Assess the Nasal Microbiome Using Third-Generation Sequencing [0.03%]
第三代测序技术评估鼻部微生物组的鼻粘膜冲洗液DNA提取方法优化
Samuel T Montgomery,Phoebe G Carr,Jose A Caparrós-Martín
Samuel T Montgomery
Sampling nasal lining fluid (NLF) via nasosorption is minimally invasive and well tolerated, but the feasibility of assessing the nasal microbiome using these samples is unknown. However, low biomass makes airway samples particularly suscep...
Julie C Worrell,Adam J Byrne
Julie C Worrell
Regulating Neutrophilic Asthma with IL-33: Maybe We Shouldn't Block IL-33 after All? [0.03%]
IL-33调节中性粒细胞型哮喘：也许我们不应该阻断IL-33了？
Alicia H Bowles,Kristi J Warren
Alicia H Bowles
Interleukin-33 Induces a Protective Response Against Irritant-induced Airway Inflammation and Dysfunction [0.03%]
白细胞介素33诱导机体对刺激物引起的气道炎症和功能紊乱产生抵抗反应
Utako Fujii,Tomotaka Nishizawa,Yumiko Ishii et al.
Utako Fujii et al.
Interleukin-33 (IL-33) released by injurious stimuli to airway epithelium activates innate lymphoid cells (ILCs) that express IL-13. IL-33 and ILCs have an important role in T2-high asthma but their influence on airway dysfunction induced b...