p19ARF Deficiency Disrupts Lung and Lipid Homeostasis Resembling the Human Alveolar Proteinosis [0.03%]
p19ARF缺失破坏肺和脂质稳态类似于人的肺泡蛋白沉积病
Lidia Jiménez-Garcia,Andrea Pérez-Montero,Sandra Herranz et al.
Lidia Jiménez-Garcia et al.
The alternative reading frame (ARF) protein, encoded by the CDKN2A locus, is well-recognized for its role in tumor suppression. Emerging evidence has highlighted ARF as a critical regulator of innate immunity and inflammation, with links to...
Impaired Taurine Transport Contributes to Bronchopulmonary Dysplasia: A Systems Biology Analysis [0.03%]
Tau导运障碍参与支气管肺发育不良发病机制的系统生物学分析
Xigang Jing,Yekai Wang,Mark Roethle et al.
Xigang Jing et al.
Metabolic dysregulation is implicated in the development of bronchopulmonary dysplasia (BPD). Taurine is an essential amino acid and a critical molecule in oxidative phosphorylation that mechanistically modulates angiogenesis. Using a neona...
Palmitoleic Acid Loss Links Pulmonary Dysbiosis to Lung Injury After Single-Lung Ventilation [0.03%]
棕榈油酸丢失连接肺部菌群失调与单肺通气后的肺损伤之间的关系
Hadis Najibi,Keyi Li,Changfu Yao
Hadis Najibi
Elizabeth F Redente,Elizabeth J Tarling
Elizabeth F Redente
Catching Fibrotic Signals: FGFR3 Decoy Receptor in Pulmonary Fibrosis [0.03%]
捕捉纤维化信号：FGFR3 decoy受体在肺纤维化中的作用
Li Luo,Quentin Philippot,Arnaud Mailleux
Li Luo
Transient receptor potential vanilloid 4 (TRPV4) channels mediate pulmonary surfactant protein A and D secretion [0.03%]
瞬时受体电位香草酸受体4介导肺表面活性蛋白A和D的分泌
Philipp Alt,Isabel Müller,Martina Kiefmann et al.
Philipp Alt et al.
Lung surfactant reduces not only surface tension at the air liquid interface, but is also involved in pulmonary host defense. This important role in innate immunity of the respiratory tract is primarily mediated by surfactant proteins A and...
Circulating B7H6 is associated with reduced NKp30 receptor expression and improved lung transplant recipient survival [0.03%]
循环B7H6与NKp30受体表达降低和肺移植受者生存率提高相关
Avishai Shemesh,Shenrae Carter,Steve R Hays et al.
Avishai Shemesh et al.
Lung transplantation prolongs survival for many patients with end-stage lung diseases. Though long-term outcomes are limited due to allograft inflammation leading to chronic rejection. In this study, we aimed to identify the role of NK cell...
RUNX1 is a mediator of fibrotic activation and epigenetic memory in lung fibroblasts [0.03%]
RUNX1是肺纤维母细胞纤维化激活和表观遗传记忆的介导因素
Rachel M Gilbert,Dakota L Jones,Jack Wellmerling et al.
Rachel M Gilbert et al.
Repetitive injury is hypothesized to lead to progressive tissue fibrosis and end-stage organ failure. Whether tissue-resident mesenchymal cell populations retain epigenetic memory of prior injuries that contribute to this pathological proce...
Phosphorothioate Backbone Modification of Oligodeoxynucleotides Induces TLR9-Independent Lung Epithelial Antimicrobial Responses [0.03%]
硫代磷酸修饰的寡脱氧核糖核苷酸通过TLR9非依赖方式诱导肺上皮抗菌反应
Yongxing Wang,Vikram V Kulkarni,Jezreel Pantaleón García et al.
Yongxing Wang et al.
Pneumonias remain a leading cause of death worldwide. Seeking novel strategies to protect susceptible patients, we have reported that inhaled delivery of a diacylated lipopeptide and a synthetic CpG oligodeoxynucleotide (ODN) protects anima...
Pure Isolation, Culture, and Post-Injury Lineage Tracing of Mouse Visceral Pleural Mesothelial Cells [0.03%]
纯隔离、培养及小鼠腹膜间皮细胞损伤后的谱系追踪研究
Akikazu Endo,Yasunori Enomoto,Ryo Horiguchi et al.
Akikazu Endo et al.
Pleural mesothelial cells (PMCs) are a major component of the pleura. The involvement of visceral PMCs has been suggested in several pleural or subpleural lung diseases, thus highlighting the importance of animal experiments using these cel...