Surfactant Protein (SP)-A Benefits Over SP-A Mutant: A Preliminary Study for ILD Treatment [0.03%]
表面活性物质蛋白(SP)-A治疗间质性肺病(ILD)的初步研究优于SP-A突变体
Tifenn Desroziers,Yohan Soreze,Marie Legendre et al.
Tifenn Desroziers et al.
Surfactant protein (SP)-A, an octadecamer composed of SP-A1 and SP-A2 is secreted into the alveolar space. Heterozygous variations in SFTPA1 and SFTPA2, reported to impair protein secretion, have been associated with interstitial lung disea...
Unraveling the Molecular Complexity of Asthma: Insights from a Multicohort Transcriptome Study [0.03%]
揭秘哮喘的分子复杂性：来自多队列转录组研究的新见解
Heidi Makrinioti,Carlos A Camargo Jr,Zhaozhong Zhu
Heidi Makrinioti
Leukotriene C4 Synthase Deficiency Causes Spontaneous Emphysema in Female Mice [0.03%]
白三烯C4合成酶缺乏导致雌性小鼠自发性肺气肿
Yumiko Ishii,Kosuke Makita,Utako Fujii et al.
Yumiko Ishii et al.
Emphysema, an important component of chronic obstructive pulmonary disease (COPD) remains poorly understood whereby there is progressive destruction of alveolar tissues. Cysteinyl-leukotrienes (cysLTs) and their receptors have been extensiv...
Down Syndrome Alters Type-III IFN and Pro-Inflammatory Airway Epithelial Responses to RSV Infection [0.03%]
21三体综合征改变I型IFN和RSV感染的气道上皮炎性反应
Elizabeth Chorvinsky,Surajit Bhattacharya,Betelehem Solomon Bera et al.
Elizabeth Chorvinsky et al.
Trisomy 21 (TS21), also known as Down syndrome (DS), increases pediatric mortality risk due to respiratory syncytial virus (RSV) by ninefold. However, the underlying immunological basis remains unclear. To define the biological implications...
Shannon Kay,Haseena Rajeevan,Moeun Son et al.
Shannon Kay et al.
Asthma prevalence and severity differs between males and females across the lifespan. Pre-pubescent males are more likely to experience asthma, but females are disproportionately affected after puberty with higher symptom burden and decreas...
PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension [0.03%]
Pink1/帕金蛋白缺乏通过增强缺氧诱导的肺血管重塑加重肺动脉高压病理进展
Rakhshinda Rehman,Paul Dieffenbach,Shamsudheen K Vellarikkal et al.
Rakhshinda Rehman et al.
Alterations in mitochondrial structure and function contribute to vascular smooth muscle cell (VSMC) phenotypic switching and are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. The PINK1/Parkin-mediated mitophagy pat...