Furin Inhibition Protects Against Acute Lung Injury in a Mouse Model of Pseudomonas Aeruginosa Infection [0.03%]
furin酶抑制剂对铜绿假单胞菌感染小鼠急性肺损伤的保护作用
Olivier Bernard,Michael Kwon,Mark R Looney et al.
Olivier Bernard et al.
Pseudomonas aeruginosa (PA) is responsible for significant morbidity and mortality particularly in patients with chronic lung diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF) as well as hos...
MCT4 mediates hypoxia-induced extracellular lactate release from IPF fibroblasts [0.03%]
MCT4介导IPF成纤维细胞中的低氧诱导的细胞外乳酸释放
Richard S Nho,Lauren Nielsen,Jessica Roberts et al.
Richard S Nho et al.
Lactate is increased in the lungs of patients with Idiopathic Pulmonary Fibrosis (IPF) and in mice with experimental lung fibrosis, and lactate has been linked to the pathogenesis of lung fibrosis. IPF fibroblasts in hypoxic conditions gene...
Whole blood transcriptomics reveals sepsis mortality-associated changes in neutrophil degranulation [0.03%]
全血转录组学揭示了与脓毒症死亡相关的中性粒细胞脱颗粒变化
Heather M Giannini,Mengyuan Kan,Christopher V Cosgriff et al.
Heather M Giannini et al.
Transcriptomic analysis of blood cells can reveal key elements of the dysregulated host response in sepsis and spur biomarker and mechanism identification. We hypothesized that sepsis nonsurvivors exhibit a distinct transcriptional signatur...
Sarah E Holton,Carmen Mikacenic
Sarah E Holton
Yunfan Hu,Ying Wang,Changhao Ren et al.
Yunfan Hu et al.
The vacuolar H+-ATPase (V-ATPase) is an enzymatic complex responsible for pumping H + into the cytosol, thereby maintaining intracellular pH; however, its role in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is unclear...
AhR activation inhibits DRP1-induced mitochondrial fission in airway smooth muscle during asthma [0.03%]
哮喘时AhR激活抑制气道平滑肌中DRP1诱导的线粒体分裂
Mohammad Irshad Reza,Cheyenne Tandberg,Ashish Kumar et al.
Mohammad Irshad Reza et al.
In asthma, pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα) drive excessive mitochondrial fission in ASM cells through activating dynamin-related protein 1 (DRP1). Recently, we demonstrated that aryl hydrocarbon recept...
Extracellular Vesicle Lipid Cargo Orchestrates Lung Inflammation and Resolution [0.03%]
细胞外囊泡脂质货物调控肺部炎症和消退
Lalithya Posham,Jon Wisler,Kimberly M Gowdy et al.
Lalithya Posham et al.
Extracellular vesicles (EVs) are increasingly recognized as critical mediators of intercellular communication, transferring a diverse repertoire of proteins, nucleic acids, and bioactive lipids that modulate the functional phenotype of reci...
Deficiency of the Collagen Endocytic Receptor MRC2 Accelerates Mouse Lung Fibroblast Proliferation [0.03%]
巨噬细胞/小胶质细胞触发受体2缺乏通过加速肺成纤维细胞增殖促进小鼠肺纤维化进展
Shota Yamamoto,Carole L Wilson,Melissa A Krueger et al.
Shota Yamamoto et al.
Mannose receptor C type 2 (MRC2) is highly expressed in the lung and is the major endocytic receptor for the internalization and degradation of collagen in mesenchymal cells. Using Mrc2 knockout (KO) mice, we previously showed that MRC2 is ...
Heavy Moms, Wheezy Kids: How Maternal Obesity Harms Breathing in Offspring [0.03%]
肥胖妈妈 气喘孩子：如何通过控制体重来保障下一代的呼吸健康
Kayla R Williams,Allison D Fryer,David B Jacoby et al.
Kayla R Williams et al.
Offspring asthma has emerged as a significant yet underexplored consequence of maternal obesity. This review synthesizes evidence from human and animal studies linking maternal obesity to increased asthma risk in offspring. We examine poten...
Deepak Tripathi,Victor J Thannickal
Deepak Tripathi