CCR5+ NK cells drive hypoxemia in endotoxin-induced acute lung injury [0.03%]
CCR5+自然杀伤细胞驱动内毒素诱导的急性肺损伤中的低氧血症
Reena Bharti,Nancy Greenland,Simon J Cleary et al.
Reena Bharti et al.
Acute lung injury (ALI) is a life-threatening clinical syndrome characterized by intense inflammation and pulmonary physiologic dysfunction. While innate immune cells dominate early ALI pathology, lymphocytes are increasingly recognized as ...
FTO Alleviates COPD Pathogenesis by Demethylating S100A9 to Suppress ERK1/2-Drp1-Driven Mitophagy [0.03%]
FTO通过去甲基化S100A9来抑制ERK1/2-Drp1介导的线粒体自噬以缓解慢性阻塞性肺疾病病理进程
Bin Xie,Qiong Chen,Ziyu Dai et al.
Bin Xie et al.
Rationale: N6-methyladenosine (m6A) modifications are implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), yet the precise role of the demethylase fat mass and obesity-associated protein (FTO) r...
Bile Acid Alteration and Alveolar Dysfunction in Cirrhosis: An Aggravating Factor or a New Piece in the Pathogenesis of Hepatopulmonary Syndrome? [0.03%]
胆汁酸改变和肝硬化的肺泡功能障碍：加重因素还是肝肺综合症发病机制的新因素？
Laurent Savale,Christophe Guignabert
Laurent Savale
Alveolar Type 2 Cell Dysfunction Is Associated with Bile Acid Alterations in Experimental Hepatopulmonary Syndrome [0.03%]
实验性肝肺综合征时胆汁酸改变与II型肺泡上皮细胞功能障碍有关
Hyo-Jin Park,Hyung Joon Cho,Peng Chen et al.
Hyo-Jin Park et al.
Hepatopulmonary syndrome (HPS) is a severe complication of cirrhosis characterized by pulmonary microvascular dilation, hypoxemia, and increased mortality. Patients often exhibit unexplained restrictive ventilatory defects that correlate wi...
Novel Role of Von Willebrand Factor-αvβ3 Integrin in Human Pulmonary Artery Smooth Muscle Cell [0.03%]
von Willebrand因子-αvβ3整合素在人肺动脉平滑肌细胞中的新作用机制研究
Sara Abd Al Rahim,Bruno Ribeiro Baptista,Huguette Louis et al.
Sara Abd Al Rahim et al.
Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis [0.03%]
胆固醇免疫代谢的改变可激活肺纤维化中巨噬细胞的NLRP3炎性小体
Mariza Vaso,Matija Dukic,Peter Pennitz et al.
Mariza Vaso et al.
Previous research has highlighted dysregulation in lipid metabolism during lung fibrosis. However, the impact of cholesterol immunometabolism during lung fibrosis progression remains unclear but has been related to the NLRP3-inflammasome ac...
Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities [0.03%]
用于模拟支气管肺发育不良严重程度的小鼠累积性新生儿高氧滴定模型
Brooke Dir,Raveena Mishra,Nicole Hennen et al.
Brooke Dir et al.
The severity of bronchopulmonary dysplasia (BPD) is defined by the type or amount of respiratory support needed at 36 weeks postmenstrual age, reflecting varying degrees of impairment in the supply and demand systems regulating arterial oxy...
Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites [0.03%]
气道分泌细胞同时包含核周高尔基复合体 ribbon 和分散的 golgi 小体卫星结构
Oanh N Hoang,Colin E Chan,Joshua M Brenner et al.
Oanh N Hoang et al.
Rationale: Finely tuned production and secretion of the polymeric mucins MUC5AC and MUCB are required for lung health, but knowledge of many details between their translation and their packaging into secretory granules is...
A FGFR3 decoy receptor attenuates lung fibroblast-to-myofibroblast transition and pulmonary fibrosis [0.03%]
FGFR3 蛋白诱骗受体可抑制肺成纤维细胞向肌成纤维细胞转化及肺纤维化的发展
Célia Scribe,Diogo Gonçalves,Marine Gautier-Isola et al.
Célia Scribe et al.
Fibroblast growth factor (FGF) signaling plays an important role in the pathogenesis of various respiratory diseases, including idiopathic pulmonary fibrosis (IPF). FGF ligands can exert both pro- and anti-fibrotic effects, depending on the...
CD44 is critical for TLR4-mediated NLRP3 inflammasome activation and the development of BPD [0.03%]
CD44在TLR4介导的NLRP3炎性小体激活及BPD发病中的关键作用
Jie Liao,Christopher Longoria,C Vivek Lal et al.
Jie Liao et al.
Rationale: Bronchopulmonary Dysplasia is a chronic lung disease of preterm infants. We previously established the NLRP3 inflammasome as critical in the pathogenesis of BPD. The hyaluronan receptor CD44 interacts with TLR4...