Choline and CCL22 Are Prognostic Blood Biomarkers for Hermansky-Pudlak Syndrome Pulmonary Fibrosis [0.03%]
胆碱和CCL22是霍曼斯基-普杜拉综合症肺纤维化的预后血液生物标志物
Muhammad Arif,Abhishek Basu,Ben Long G Zuo et al.
Muhammad Arif et al.
Identifying molecular biomarkers of pulmonary fibrosis (PF) would improve monitoring the disease progression and response to treatment. Hermansky-Pudlak syndrome (HPS) PF is an inherited type of progressive PF with accelerated onset of PF i...
Targeting CD48 Ameliorates ILC2-mediated Airway Hyperreactivity by Disrupting the PKCβ Pathway [0.03%]
靶向CD48通过破坏PKCβ通路缓解ILC2介导的气道高反应性
Kei Sakano,Yoshihiro Sakano,Benjamin P Hurrell et al.
Kei Sakano et al.
CD48 is a cell surface protein belonging to the signaling lymphocyte activation molecule family and is known to regulate immune cell function. Although asthma has traditionally been associated with adaptive immune responses, recent evidence...
ER Stress Disrupts the Airway Epithelium and Reduces Host Defense during Influenza A Virus Infection [0.03%]
内质网应激在A型流感病毒感染过程中破坏气道上皮并降低宿主防御能力
Erin Y Earnhardt,Jennifer L Tipper,Mohamed A Hanafy et al.
Erin Y Earnhardt et al.
Secondary Streptococcus pneumoniae (Spn) infection to influenza A virus (IAV) frequently leads to an increase in morbidity and mortality of IAV. Our recent work establishes that IAV infection disrupts bacterial host defense in the lung epit...
Transcriptomics in T2-High Severe Asthmatics Treated with Biologics: Comparison Between Anti-IgE, Anti-IL-5 and Anti-IL-5R-Targeted Treatments [0.03%]
生物制剂治疗T2高表达重度哮喘的转录组学研究：抗IgE、抗IL-5和抗IL-5R靶向疗法之间的比较
Sara Gerday,Florence Schleich,Mare Sabbe et al.
Sara Gerday et al.
David R Ziehr,Raghu R Chivukula
David R Ziehr
Multi-omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease [0.03%]
多组学和单细胞方法阐明肺部疾病细胞生物学和病理生物学
Aartik Sarma,Xin Sun,Jennifer Sucre et al.
Aartik Sarma et al.
In this Perspective, we review the major themes from a Basic Science Core session at ATS 2024: Multi-omic and single-cell approaches for elucidating cellular biology and pathobiology of lung disease, with a focus on novel biology identified...
Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development [0.03%]
靶向CELA1可改善新生小鼠缺氧模型肺泡隔的发育缺陷
Noah J Smith,Rashika Joshi,Hitesh Deshmukh et al.
Noah J Smith et al.
Taehyun Kim,Sungmin Moon,Juyeon Lee et al.
Taehyun Kim et al.
When Lipid Mediators Keep Lungs Whole: A Spontaneous, Female-Predominant Model of Emphysema [0.03%]
脂质介质保持肺完整的机制：一种自发的、以女性为主的肺气肿模型
Rene A Girard,Harry Karmouty-Quintana
Rene A Girard