CircMIRLET7BHG facilitates mast cell degranulation to accelerate AR progression by enhancing IL-33 mRNA stability via interacting with PTBP1 [0.03%]
CircularRNA CircMIRLET7BHG通过与PTBP1互作增强IL-33mRNA稳定性促进mast细胞脱颗粒来加速过敏反应进展
Jiabin Zhan,Rui Li,Yisen Liang et al.
Jiabin Zhan et al.
Mast cell (MC) degranulation is associated with allergic rhinitis (AR) progression. Although circMIRLET7BHG has been identified as a promoter of AR development, its potential regulatory role in MC degranulation during AR progression has not...
Regional micro-CT analysis enables longitudinal detection of compensatory ventilation effects in a mouse model of pulmonary fibrosis [0.03%]
基于小鼠肺纤维化的纵向观察，区域微焦层析扫描技术可检测代偿性通气效应
Martina Buccardi,Francesca Pennati,Erica Ferrini et al.
Martina Buccardi et al.
Accurate lung function assessment is essential in preclinical idiopathic pulmonary fibrosis (IPF) research, yet conventional whole-lung endpoints overlook spatial heterogeneity and compensatory mechanisms. We present a µCT-based pipeline f...
Reply to Chen et al.: Defining the Translational Validity of CTPA-Derived Pulmonary Blood Volume in CTEPH [0.03%]
致陈等人：CTPA衍生的肺血容量在CTEPH中的翻译有效性探讨回复
Hakim Ghani,Muhunthan Thillai,Simon Walsh et al.
Hakim Ghani et al.
Pulmonary Blood Volumes on CT Predict Residual Pulmonary Hypertension Post-Pulmonary Endarterectomy [0.03%]
术前CT肺血流量可预测肺动脉内膜剥脱术后持续性肺高血压
Hakim Ghani,Muhunthan Thillai,David Jenkins et al.
Hakim Ghani et al.
Pulmonary blood volumes (PBV), currently not assessed by computed tomography pulmonary angiography (CTPA), could provide additional information to routine investigations performed for chronic thromboembolic pulmonary hypertension (CTEPH). W...
Piezo1 Mediates Stretch-Induced Wnt/β-Catenin Signaling and ECM Remodeling in Aging Asthmatic Airway Smooth Muscle [0.03%]
张力诱导的派克森林第1信号通路调节哮喘气道平滑肌衰老中Wnt/β-catenin信号转导和细胞外基质重塑
Niyati A Borkar,Daniel A Pfeffer-Kleemann,Samantha K Hamrick et al.
Niyati A Borkar et al.
Asthma in the elderly (AIE) represents a unique challenge, necessitating better understanding of the mechanisms that drive airway hyperreactivity and remodeling (thickened, fibrotic airways). Normal aging is associated with increased lung s...
Long isoforms of the COPD risk gene FAM13A orchestrate human lung epithelial development [0.03%]
囊性纤维化跨膜传导调节蛋白基因长转录本调控人类肺上皮发育
Rhiannon B Werder,Méline Homps-Legrand,Rebecca Hyatt et al.
Rhiannon B Werder et al.
Impaired lung development and lung function can lead to the development of chronic obstructive pulmonary disease (COPD). Genome wide association studies (GWAS) have identified associations between variants in the gene FAM13A with both lung ...
α5 Nicotinic Receptor Polymorphism affects cigarette smoke-induced inflammation and COPD development [0.03%]
α5烟碱型乙酰胆碱受体多态性影响吸烟引起的炎症和慢性阻塞性肺疾病发病风险
Layal Massara,Lynda Saber Cherif,Anais Ollivier et al.
Layal Massara et al.
Rationale: COPD is the third leading cause of death globally. Although cigarette smoke is the dominant risk factor, only a subset of smokers develop COPD, pointing to a significant role for genetic susceptibility. The α5...
Ioannis Siokas,Morgan Heileman,Lawrence C Fritz et al.
Ioannis Siokas et al.
Regulated cell death is critical in maintaining tissue homeostasis and immune functions. The most common form of physiologic cell death is the highly precise, regulated, and relatively inflammation-free pathway of apoptosis. In contrast, ne...