Lentiviral-mediated gene complementation to rescue pathogenic ABCA3 variants [0.03%]
lentivirus介导的基因补偿矫正ABCA3致病突变
Ashley L Cooney,Shakayla Lamer,Ping Yang et al.
Ashley L Cooney et al.
The ATP-binding cassette subfamily A member 3 (ABCA3) protein in the limiting membrane of lamellar bodies in alveolar type 2 (AT2) cells transports phospholipids required for pulmonary surfactant assembly. ABCA3 deficiency results from bial...
Fibroblast memory Runx Deep: Epigenetic Recall in Pulmonary Fibrosis [0.03%]
成纤维细胞记忆RUNX深刻：肺纤维化中的表观遗传回忆
Jonathan S Kurche,Elizabeth F Redente
Jonathan S Kurche
Novel Netrin-1-Unc5b-Klf4 axis balances AT2 survival in experimental bronchopulmonary dysplasia [0.03%]
新型Netrin-1-Unc5b-Klf4轴在实验性支气管肺发育不良中平衡AT2存活
Oleksiy Klymenko,Jasmine Mohr,Soula Danopoulos et al.
Oleksiy Klymenko et al.
Alveolar growth and repair are central processes in development and chronic lung disease, such as bronchopulmonary dysplasia (BPD), a neonatal lung disease without curative therapy. Alveolar epithelial type 2 cells (AT2) are the endogenous ...
SPP1+ Macrophages Contribute to Silica-Induced Pulmonary Inflammation and Fibrosis via the ERK/JNK Signaling Pathway [0.03%]
SPP1+巨噬细胞通过ERK / JNK信号传导途径促进二氧化硅诱导的肺部炎症和纤维化
Di Sun,Yuanying Wang,Ruimin Ma et al.
Di Sun et al.
Secreted phosphoprotein 1-positive (SPP1+) macrophages play a critical role in the progression of silicosis, but their regulatory mechanisms remain unclear. In this study, we integrated single-cell RNA sequencing and spatial transcriptomics...
Optogenetic vagotomy inhibits reflex bronchoconstriction and cardiac chronotropy [0.03%]
光遗传性迷走神经切断术抑制反射性支气管收缩和心脏速率反应
Aubrey B Pierce,Alexandra B Pincus,James Kornfield et al.
Aubrey B Pierce et al.
Optogenetics involves genetic insertion of light-sensitive ion channels into nerves, such as with cre-based recombination. The recent increase in cre-based mouse lines has expanded our ability to test the roles of peripheral nerves in homeo...
The airway epithelial muco-inflammatory response to IL-13 is exacerbated in Cystic Fibrosis [0.03%]
白细胞介素13诱导的气道上皮粘液炎症反应在囊性纤维化患者中被加剧
Gianna Swanger,Mason Donnell,John Sembrat et al.
Gianna Swanger et al.
Anellovirus-Mediated Interferon Dysregulation Enhances Virus-Induced Lung Injury [0.03%]
环状病毒介导的干扰素失调节增强病毒引起的肺损伤
Mudassir M Banday,Shahid Banday,Mizanur Rahman et al.
Mudassir M Banday et al.
Background: The lung virome (LV) and its interactions with the host-immune system leading to allograft injury after lung transplantation are not well characterized. ...
Myeloid TLR2 signaling amplifies immunopathology in influenza-infected murine neonates [0.03%]
髓系TLR2信号传导可放大流感病毒感染的鼠新生儿免疫病理损伤
Abhishek S Rao,Abigail P Onufer,Ogan Kumova et al.
Abhishek S Rao et al.
We previously demonstrated pretreatment with intranasal Lactobacillus rhammosus GG (LGG) prior to influenza viral (IAV) infection protected murine neonates through toll-like receptor (TLR) priming. Based on these results, we hypothesized ne...
TSG-6 promotes Fascin-1-Mediated Microvascular Repair in Murine Airway Allografts [0.03%]
TSG-6通过促进Fascin-1介导的小血管修复促进小鼠气道同种异体移植物的修复
Mohammad Afzal Khan,Dong Ge Li,Subarna Bhusal et al.
Mohammad Afzal Khan et al.
Bronchial anastomotic complications, including stenosis, necrosis, and dehiscence, remain major contributors to morbidity and poor graft outcomes following lung transplantation. These complications are primarily driven by microvascular disr...