Temporal Type I IFN Signaling Orchestrates Protective and Pathogenic Inflammation Post-Influenza [0.03%]
流感病毒感染后时空1型干扰素信号通路协调保护性和致病性炎症反应
Md Bashir Uddin,Michael McKelvey,Sunil Palani et al.
Md Bashir Uddin et al.
Secondary bacterial pneumonia following influenza A virus (IAV) infection markedly exacerbates lung inflammation and contributes to acute respiratory distress syndrome (ARDS); however, the immunologic pathways that drive lung injury and det...
FOXJ1 transcriptional targets in human airway cells and impaired multiciliogenesis in FOXJ1-associated primary ciliary dyskinesia [0.03%]
人呼吸道上皮细胞中的FOXJ1转录靶基因及FOXJ1相关原发性纤毛运动障碍中多纤毛生成的缺陷
Lucie Thomas,Jacques Serizay,Rahma Mani et al.
Lucie Thomas et al.
Fluid mobilization on epithelia is ensured by the motile cilia of differentiated multiciliated cells (MCCs). Key transcriptional regulators of motile ciliogenesis include CCNO, MCIDAS, RFXs, and the transcription factor FOXJ1, whose precise...
Reduction of Palmitoleic Acid Due to Changes in Pulmonary Microbiota Contributes to Acute Lung Injury After Single-Lung Ventilation [0.03%]
单肺通气后由于肺微生物群变化导致棕榈油酸减少从而促进急性肺损伤发生
Zhizhi Wang,Zhiming Chen,Tianlan Ye et al.
Zhizhi Wang et al.
Background: Single-lung ventilation (SLV), commonly used in thoracic surgery, carries a risk of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Our previous studies suggest that pulmonary microbiot...
Rescue of ABCA3 deficiency needs to consider variant-specific epithelial cell dysfunction beyond surfactant production [0.03%]
ABCA3缺陷的治疗需要考虑变体特异性上皮细胞功能障碍而不仅仅是表面活性物质的产生
Florian Gothe,Matthias Griese
Florian Gothe
Efficient CRISPR-Cas RNP-based gene targeting of human AT2 cells [0.03%]
高效的人AT2细胞CRISPR-Cas碱基编辑基因敲除模型
Tristan Kooistra,Tresa R Sarraf,Michelle Chen et al.
Tristan Kooistra et al.
Alveolar type 2 (AT2) cells play numerous roles in the alveolus related to stem cell, immunoregulatory, and secretory functions. Primary human AT2 cells can now be isolated and studied as organoids consisting of self-organizing epithelial t...
MLKL Regulates Intracellular Trafficking of Neutrophil Elastase to Promote Lung Epithelial Cell Senescence [0.03%]
MLKL调节中性粒细胞弹性蛋白酶的胞内运输以促进肺上皮细胞衰老
Rong Liu,Aifang Zhang,Steven D Shapiro et al.
Rong Liu et al.
Neutrophil elastase (NE) is a key contributor to the pathogenesis of chronic obstructive pulmonary disease (COPD), driving airway inflammation and tissue destruction. While the RIPK3/MLKL-mediated necroptosis has been implicated in cigarett...
Li Li,Sucai Liu,Zhe Lei et al.
Li Li et al.
CD55 is an immune regulator that inhibits T cell activation and also binds to CD97, a molecule involved in immune cell migration and signaling. While CD55 expression is reduced in chronic beryllium disease (CBD), its functional role in dise...
Nintedanib increases BCL-2 in fibrotic fibroblasts enhancing ABT-199 apoptosis and fibrosis resolution [0.03%]
尼替尼布增加纤维化成纤维细胞中Bcl-2的量，从而增强ABT-199诱导的细胞凋亡和促进组织纤维化的消退
Joseph C Cooley,Sarah K Penick,Jasmine A Wilson et al.
Joseph C Cooley et al.
Rationale: Progressive fibrosing interstitial lung diseases (PF-ILDs) have a large global impact and there is a pressing need to develop new therapies. Ob...