Pulmonary Microvascular Endothelial Cells Support Alveolar Epithelial Growth via Bone Morphogenetic Protein 6 Secretion [0.03%]
肺微血管内皮细胞通过骨形态发生蛋白6的分泌支持肺泡上皮的生长
Luke van der Koog,Xinhui Wu,Dyan F Nugraha et al.
Luke van der Koog et al.
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and emphysema development, associated with enhanced tissue destruction and defective repair. Supporting cells in the alveolar niche play a cruci...
ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in COPD [0.03%]
抗衰老途径的组分ANT1缺陷通过影响巨噬细胞代谢和迁移对慢性阻塞性肺疾病相关的肺气肿产生保护作用
Justin Sui,Aaron R Johnson,Theodore S Kapellos et al.
Justin Sui et al.
Macrophage-mediated inflammation drives various lung diseases, including chronic obstructive pulmonary disease (COPD). COPD macrophages have dysfunctional mitochondrial metabolism and function which lead to a chronic inflammatory lung envir...
Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases [0.03%]
偏向性激动与变构调节：用于开发抗阻塞性气道疾病新类β受体激动剂的新兴策略
Sushrut D Shah,Deepak A Deshpande
Sushrut D Shah
The obstructive lung diseases (OLDs) asthma and chronic obstructive pulmonary disease are characterized by bronchoconstriction and difficulty in breathing. Agonists of β2-adrenergic receptors (β-agonists) are the most commonly used bronch...
Comparison of Droplet- and Microwell-based Methods to Analyze Cryopreserved Human Bronchoalveolar Lavage Cells by scRNA-Sequencing [0.03%]
基于液滴和微孔的单细胞转录组测序分析冻存人的肺泡灌洗细胞并进行比较
Pierre Janssen,Joan Abinet,Latifa Karim et al.
Pierre Janssen et al.
Single-cell and single-nuclei RNA sequencing (scRNA-seq) has revolutionized the exploration of tissue biology and cellular heterogeneity by delivering transcriptomic data at the individual cell level. Yet, the logistical challenge of utiliz...
HERC6 and KCNQ3 Expression Associated with Primary Ciliary Dyskinesia and Nasal Nitric Oxide Levels [0.03%]
与原发性纤毛运动障碍和鼻内源性一氧化氮水平相关的HERC6和KCNQ3表达
Minako Hijikata,Kozo Morimoto,Masashi Ito et al.
Minako Hijikata et al.
The Acrolein - Lipopolysaccharide Mouse Model for Frequent Exacerbations in COPD [0.03%]
用于慢性阻塞性肺疾病(COPD)急性加重的小鼠模型中的丁 acids和脂多糖模型
Bernhard Fe Reiter,Natalie Bordag,Diana Schnoegl et al.
Bernhard Fe Reiter et al.
Chronic obstructive pulmonary disease (COPD) is a severe progressive lung disease, often caused by prolonged exposure to cigarette smoke and environmental factors. Pre-clinical COPD research predominately relies on chronic smoke or elastase...
VEGF-D Protects the Lung in Neonatal Hyperoxia-induced Lung Injury [0.03%]
VEGF-D通过下调血管生成和纤维化相关基因的表达保护一氧化氮所致新生儿肺损伤
Lakshanie C Wickramasinghe,Elan L&#x;Estrange-Stranieri,Bailey Cardwell et al.
Lakshanie C Wickramasinghe et al.
Bronchopulmonary dysplasia (BPD) is a serious lung disease that affects premature infants born with developmentally immature lungs. Supplemental oxygen, while a lifesaving treatment, provokes inflammation and oxidative stress causing microv...
HDLBP Promotes Glycolysis and CD8+ T Cell Exhaustion in Lung Adenocarcinoma by Stabilizing GJB2 RNA [0.03%]
HDLBP通过稳定GJB2 mRNA促进肺腺癌糖酵解和CD8⁺T细胞衰竭
Li Xu,Bin Zhou,Kaiqi Jin et al.
Li Xu et al.
Gap junction protein beta 2 (GJB2) has been associated with glycolysis and immunosuppression in human tumors. This research aims to explore the roles of GJB2 in these aspects in the context of lung adenocarcinoma (LUAD). GJB2 expression in ...
Matrix Softness Induces an Afibrogenic Lipofibroblast Phenotype in Fibroblasts from IPF Patients [0.03%]
基质软度诱导特发性肺纤维化患者的成纤维细胞向心房颤脂质纤维母细胞表型的转化
Asres Berhan,Avanka Gunatilaka,Chiaohwei Lee et al.
Asres Berhan et al.
Contractile myofibroblasts immersed in stiffened remodelled extracellular matrix (ECM) characterise fibrotic lesions in idiopathic pulmonary fibrosis (IPF). Lipofibroblasts are lipid-droplet containing interstitial fibroblasts that support ...
Casein Kinase 1 Delta (CK1δ) Is Implicated in TGF-β1 Activation of Human Lung Myofibroblasts [0.03%]
酪蛋白激酶1 delta在TGF-β1活化人肺肌成纤维细胞中的作用
Meina Li,Stephanie S Zhang,Trudi Harris et al.
Meina Li et al.