Piezo1 Agonist Yoda1 Induces Rapid Relaxation in Cultured Airway Smooth Muscle Cells and Bronchodilation in Mouse Models [0.03%]
Piezo1激动剂Yoda1可使培养的气道平滑肌细胞迅速松弛并使小鼠模型支气管扩张
Mingzhi Luo,Xiangrong Zhang,Jia Guo et al.
Mingzhi Luo et al.
Bronchodilators that relax airway smooth muscle cells (ASMCs) are essential for treating constrictive airway diseases such as asthma. However, the existing bronchodilators are often unable to control symptoms of severe asthmatic patients, l...
Atefeh Razazan,Md Habibul Hasan Mazumder,William Travis Goldsmith et al.
Atefeh Razazan et al.
Ozone (O3) is a criteria pollutant that is anticipated to rise over the next decade due to climate-related activity. Varying amounts of nitrogen oxides (NOx) are produced as by-products during O3 generation from oxygen depending on the meth...
Optimisation of DNA Extraction from Nasal Lining Fluid to Assess the Nasal Microbiome Using Third-Generation Sequencing [0.03%]
第三代测序技术评估鼻部微生物组的鼻粘膜冲洗液DNA提取方法优化
Samuel T Montgomery,Phoebe G Carr,Jose A Caparrós-Martín
Samuel T Montgomery
Sampling nasal lining fluid (NLF) via nasosorption is minimally invasive and well tolerated, but the feasibility of assessing the nasal microbiome using these samples is unknown. However, low biomass makes airway samples particularly suscep...
Julie C Worrell,Adam J Byrne
Julie C Worrell
Regulating Neutrophilic Asthma with IL-33: Maybe We Shouldn't Block IL-33 after All? [0.03%]
IL-33调节中性粒细胞型哮喘：也许我们不应该阻断IL-33了？
Alicia H Bowles,Kristi J Warren
Alicia H Bowles
Interleukin-33 Induces a Protective Response Against Irritant-induced Airway Inflammation and Dysfunction [0.03%]
白细胞介素33诱导机体对刺激物引起的气道炎症和功能紊乱产生抵抗反应
Utako Fujii,Tomotaka Nishizawa,Yumiko Ishii et al.
Utako Fujii et al.
Interleukin-33 (IL-33) released by injurious stimuli to airway epithelium activates innate lymphoid cells (ILCs) that express IL-13. IL-33 and ILCs have an important role in T2-high asthma but their influence on airway dysfunction induced b...
Pulmonary Fibrosis - Focusing on the Future: Aspen Lung Conference 2024 Summary [0.03%]
肺纤维化——聚焦未来：阿斯彭肺部大会 2024总结报告
Margaret A T Freeberg,Elizabeth F Redente,Apostolos Perelas et al.
Margaret A T Freeberg et al.
As medical and scientific communities, we have enjoyed exciting advances in our mechanistic understanding, diagnosis, and therapy of different types of lung fibrosis. However, much still needs to be learned as we are challenged to make earl...
Airway Immune Signatures in Severe and Fatal Infection with COVID-19 [0.03%]
COVID-19重症和危重患者的呼吸道免疫特征分析
Naresh Doni Jayavelu,Jing Jing Qi,Slim Fourati et al.
Naresh Doni Jayavelu et al.
Peripheral Transcriptome of Severe Sarcoidosis Involves Dysregulation of Multiple Immunologic Systems [0.03%]
严重肉芽肿病的外周转录组涉及多个免疫系统的失调
Kai Huang,Jessica M Lee,Wangfei Wang et al.
Kai Huang et al.