Leukotriene C4 Synthase Deficiency Causes Spontaneous Emphysema in Female Mice [0.03%]
白三烯C4合成酶缺乏导致雌性小鼠自发性肺气肿
Yumiko Ishii,Kosuke Makita,Utako Fujii et al.
Yumiko Ishii et al.
Emphysema, an important component of chronic obstructive pulmonary disease (COPD) remains poorly understood whereby there is progressive destruction of alveolar tissues. Cysteinyl-leukotrienes (cysLTs) and their receptors have been extensiv...
Down Syndrome Alters Type-III IFN and Pro-Inflammatory Airway Epithelial Responses to RSV Infection [0.03%]
21三体综合征改变I型IFN和RSV感染的气道上皮炎性反应
Elizabeth Chorvinsky,Surajit Bhattacharya,Betelehem Solomon Bera et al.
Elizabeth Chorvinsky et al.
Trisomy 21 (TS21), also known as Down syndrome (DS), increases pediatric mortality risk due to respiratory syncytial virus (RSV) by ninefold. However, the underlying immunological basis remains unclear. To define the biological implications...
Shannon Kay,Haseena Rajeevan,Moeun Son et al.
Shannon Kay et al.
Asthma prevalence and severity differs between males and females across the lifespan. Pre-pubescent males are more likely to experience asthma, but females are disproportionately affected after puberty with higher symptom burden and decreas...
PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension [0.03%]
Pink1/帕金蛋白缺乏通过增强缺氧诱导的肺血管重塑加重肺动脉高压病理进展
Rakhshinda Rehman,Paul Dieffenbach,Shamsudheen K Vellarikkal et al.
Rakhshinda Rehman et al.
Alterations in mitochondrial structure and function contribute to vascular smooth muscle cell (VSMC) phenotypic switching and are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. The PINK1/Parkin-mediated mitophagy pat...
Interferon Mediated Bronchial Epithelium Cellular Senescence in Chronic Obstructive Pulmonary Disease [0.03%]
慢性阻塞性肺疾病介导的支气管上皮细胞衰老的影响因子
Hong Guo-Parke,Oisin Cappa,Dermot A Linden et al.
Hong Guo-Parke et al.
Cellular senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). The mechanisms of senescence in the bronchial epithelium, however, remain largely unknown. This study aimed to elucidate whether ce...
Targeted Pre-Conditioning and Cell Transplantation in the Murine Lower Respiratory Tract [0.03%]
针对小鼠下呼吸道的靶向预处理和细胞移植
Anat Kohn,Michael J Herriges,Payel Basak et al.
Anat Kohn et al.
Transplantation of airway basal stem cells could achieve a durable cure for genetic diseases of the airway, such as cystic fibrosis and primary ciliary dyskinesia. Recent work demonstrated the potential of primary- and pluripotent stem cell...
Extracellular Vesicles Contribute to the Pathophysiology and Progression of Pleural Fibrosis by Promoting MesoMT and Neo-Angiogenesis [0.03%]
外泌体通过促进间充质细胞转分化和新生血管生成参与胸膜纤维化病理生理过程及疾病进展
Kaushik Das,Wenyi Qin,Ann Jeffers et al.
Kaushik Das et al.
Severe pleural space inflammation associated with exudative pleural effusions leads to the development of pleural fibrosis (PF). Pathological tissue remodeling in PF is associated with profibrotic changes in the pleural mesothelium and neo-...