Infants who develop BPD have an airway endotype defined by vimentin expression and ciliary loss [0.03%]
发育成呼吸窘迫综合征的婴儿具有由波形蛋白表达和纤毛丢失定义的气道表型
Laurie C Eldredge,Yan Han,Gail H Deutsch et al.
Laurie C Eldredge et al.
Rationale: Bronchopulmonary Dysplasia (BPD) arises from disrupted lung development after preterm birth and produces structural deficits at every level of the respiratory tree. Lower airway disease is emerging as a clinica...
Lung endothelial cytopathic tau is sufficient to impair long-term potentiation during infection [0.03%]
感染期间肺内皮细胞病理性tau蛋白足以损害长期增强作用
Mike T Lin,Mikhail Alexeyev,Jakob Körbelin et al.
Mike T Lin et al.
Cytopathic tau variants are recovered from the lung, circulation, and brain following lower respiratory tract infection. Cytopathic tau injures the lung and brain, yet its cellular origin during infection is unknown. Here, we assessed wheth...
mRNA therapy improves the composition and motility in CCDC40-deficient cilia in vitro and in vivo [0.03%]
基于mRNA的治疗可改善CCDC40缺陷纤毛的体内外组成和运动性
Kai Wohlgemuth,Margarida Rasteiro,Manish Aneja et al.
Kai Wohlgemuth et al.
Primary Ciliary Dyskinesia (PCD) is a genetically heterogeneous disorder leading to destructive airway disease with severe bronchiectasis and chronic lung failure in adulthood. Pathogenic variants in CCDC40 are associated with more severe r...
MGST2hi PMNs mediate NETs and drive pericyte-to-myofibroblast transition in RA-ILD [0.03%]
RA-ILD中MGST2hi PMN介导NET并驱动周细胞向肌成纤维细胞转化
Jing Xue,Miaomiao Nian,Yangyang Liang et al.
Jing Xue et al.
Neutrophil extracellular trap (NET) formation has been implicated in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD), yet the specific neutrophil subsets involved and the mechanisms remain incompletely...
Lung-Protective and Neurotoxic: The Double-Edged Sword of Tau in Respiratory Infections [0.03%]
双刃剑tau蛋白：保护肺功能和神经毒性在呼吸道感染中的作用
Ajay Keerthy,Joseph A Hippensteel
Ajay Keerthy
A novel S1P analogue/MLCK inhibitory peptide-encargoed nanocarrier to attenuate lung vascular leak [0.03%]
一种新型S1P类似物/MLCK抑制肽包载纳米递送载体用于改善肺血管通透性损伤的研究
Saad Sammani,Tadeo Bermudez,Carrie L Kempf et al.
Saad Sammani et al.
Unremitting increases in lung vascular permeability is the pathophysiological hallmark of acute lung injuries (ALI) and drives both severity and mortality. Therapies with the capacity to quickly restore vascular integrity in ALI remains a s...
Highly Effective Modulator Therapies Restore Neutrophil Dysfunction in People with Cystic Fibrosis [0.03%]
高效的调节疗法可恢复囊性纤维化患者的中性粒细胞功能
Frank H Robledo-Avila,Raul Rascon,Alejandra Montanez-Barragan et al.
Frank H Robledo-Avila et al.
Cystic fibrosis (CF) is a common genetic disease caused by a defective CF-transmembrane conductance regulator (CFTR). People with CF (pwCF) are prone to develop infections by opportunistic pathogens, including Burkholderia cenocepacia, lead...
Asthmatic Pulmonary Fibroblasts Aggravate Airway Inflammation Through FKBP5-Dependent Necroptosis [0.03%]
FKBP5依赖的肺纤维母细胞坏死性凋亡加重气道炎症反应
Dong Zhang,Wei Liu,Tao Wang et al.
Dong Zhang et al.
Airway inflammation is a hallmark pathological feature of bronchial asthma and is closely associated with airway hyperresponsiveness. Pulmonary fibroblasts are key contributors to asthmatic inflammation, yet the underlying mechanisms remain...