Siglec-F Deficiency Prevents Fibrosis after Bleomycin-induced Acute Lung Injury [0.03%]
Siglec-F缺乏可防止博来霉素诱导的急性肺损伤后的纤维化发生
Marika Orlov,Naoko Hara,Sunad Rangarajan et al.
Marika Orlov et al.
Single-Cell Multiome Impact of Prenatal Heavy Metal Exposure on Early Airway Development [0.03%]
孕期重金属暴露对早期气道发育的单细胞多组学影响
Boris Minasenko,Dongxue Wang,Jessica Chan et al.
Boris Minasenko et al.
Prenatal exposure to cadmium (Cd) and arsenic (As) can severely impair fetal lung development, leading to lifelong adverse effects. As two of the most common and toxic heavy metals, Cd and As pose risks to many communities through food and ...
Influenza A Virus Following Radiotherapy Amplifies Lung Injury and Monocyte-derived Macrophage Responses [0.03%]
放射治疗后的流感A病毒加重肺损伤和单核细胞来源的巨噬细胞反应
Angela M Groves,Carl J Johnston,Nicole D Paris et al.
Angela M Groves et al.
Improvements in radiation therapy (RT) for thoracic cancers have increased survival, thus preventing radiotoxicity in normal lung tissue becomes even more important. Respiratory infection is a lung stressor that increases the risk of RT tox...
Yung-An Huang,Taylor A Doherty
Yung-An Huang
Wenjie Wang,Shiyi Chen,Zhuyi Xi et al.
Wenjie Wang et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, interstitial lung disease lacking efficient drug to reverse it. Thus, to elucidate the complex pathogenesis of IPF and identify new therapeutic targets are urgently needed. It h...
Hyaluronan Ameliorates Viral Pneumonia in Mice and Humans by Inhibiting E2F1 Transcription Factor [0.03%]
透明质酸通过抑制E2F1转录因子改善病毒性肺炎
Vandy P Stober,Carol S Trempus,Flavia Galdi et al.
Vandy P Stober et al.
Rationale: Viral lung infections are a major cause of morbidity and mortality worldwide. Despite significant advances in vaccines and antivirals, there remains a tremendous need for broadly applicable treatments that can ...
Choline and CCL22 Are Prognostic Blood Biomarkers for Hermansky-Pudlak Syndrome Pulmonary Fibrosis [0.03%]
胆碱和CCL22是霍曼斯基-普杜拉综合症肺纤维化的预后血液生物标志物
Muhammad Arif,Abhishek Basu,Ben Long G Zuo et al.
Muhammad Arif et al.
Identifying molecular biomarkers of pulmonary fibrosis (PF) would improve monitoring the disease progression and response to treatment. Hermansky-Pudlak syndrome (HPS) PF is an inherited type of progressive PF with accelerated onset of PF i...
Targeting CD48 Ameliorates ILC2-mediated Airway Hyperreactivity by Disrupting the PKCβ Pathway [0.03%]
靶向CD48通过破坏PKCβ通路缓解ILC2介导的气道高反应性
Kei Sakano,Yoshihiro Sakano,Benjamin P Hurrell et al.
Kei Sakano et al.
CD48 is a cell surface protein belonging to the signaling lymphocyte activation molecule family and is known to regulate immune cell function. Although asthma has traditionally been associated with adaptive immune responses, recent evidence...
ER Stress Disrupts the Airway Epithelium and Reduces Host Defense during Influenza A Virus Infection [0.03%]
内质网应激在A型流感病毒感染过程中破坏气道上皮并降低宿主防御能力
Erin Y Earnhardt,Jennifer L Tipper,Mohamed A Hanafy et al.
Erin Y Earnhardt et al.
Secondary Streptococcus pneumoniae (Spn) infection to influenza A virus (IAV) frequently leads to an increase in morbidity and mortality of IAV. Our recent work establishes that IAV infection disrupts bacterial host defense in the lung epit...