Enhancing the Anti-Fibrotic Potential of the Endothelium: Lipid Nanoparticles to the Rescue [0.03%]
脂质纳米颗粒增强血管内皮抗纤维化潜力
Patricia L Brazee,Rachel S Knipe
Patricia L Brazee
Enter the Matrix: Fibroblast Transcriptome and Matrisome Alterations Direct Fibrotic Transitions in Influenza-Mediated Lung Injury [0.03%]
流感介导的肺损伤中成纤维细胞转录组和基质组变化引导纤维化转换：进入矩阵
Jeffrey R Koenitzer
Jeffrey R Koenitzer
Ectopic Expression of MUC5B in the Respiratory Bronchiole Initiates Endoplasmic Reticulum Stress in the IPF Lung [0.03%]
MUC5B在呼吸性细支气管的异位表达引发IPF肺内质网应激反应
Rachel Z Blumhagen,Jonathan S Kurche,Carlyne D Cool et al.
Rachel Z Blumhagen et al.
We used spatial transcriptomics from idiopathic pulmonary fibrosis (IPF) and unaffected control lung tissue to further understand the pathogenesis of MUC5B-driven lung fibrosis. We captured 43 fields of view in 15 IPF and 13 controls with a...
NSUN2 Promotes the Growth, Metastasis and Glutamine Metabolism of Non-Small Cell Lung Cancer [0.03%]
NSUN2促进非小细胞肺癌生长、转移及谷氨酰胺代谢
Yifan Zheng,Chunhui Ma,Shengguang Ding et al.
Yifan Zheng et al.
As a 5-methylcytosine (m5C) methyltransferase, increased NOP2/Sun RNA methyltransferase 2 (NSUN2) has been revealed to promote the progression of non-small cell lung cancer (NSCLC) through m5C modification. Herein, this study aimed to inves...
Combined Inhibition of FABP4/5 Ameliorates Pulmonary Hypertension by Reducing Pulmonary Vascular and Right Ventricular Fibrosis [0.03%]
FABP4/5联合抑制通过减少肺血管和右心室纤维化来改善肺动脉高压
Juan Li,Yi Shen,Xi Qiu et al.
Juan Li et al.
Lipid metabolism disorder is increasingly recognized as hallmarks of Pulmonary hypertension (PH). Fatty acid-binding proteins (FABPs), particularly FABP4 and FABP5, which regulate lipid transport and metabolism of fatty acid, are thought to...
Toward Human Lung Regeneration: Gaining Insights from the Axolotl Salamander Ambystoma mexicanum [0.03%]
取自墨西哥轴突变色龙的肺再生研究为人类肺再生提供了新思路
Aaron C Dobie,Wathone Win,Darrell N Kotton et al.
Aaron C Dobie et al.
Lung-targeted Lipid Nanoparticle Delivery of a Matricellular mRNA Promotes Fibrotic Lung Repair [0.03%]
靶向肺的脂质纳米颗粒递送基质细胞因子mRNA促进肺纤维修复
Kalpana R Betageri,Jeffrey A Meridew,Brian J Parrett et al.
Kalpana R Betageri et al.
Pulmonary fibrosis is increasingly understood to involve dysfunction within and across multiple cellular compartments, with recent attention highlighting the involvement of pulmonary vascular dysfunction in failed repair and progression of ...
Mansi Upadhyay,Destini Nelson,Mollie Phillips et al.
Mansi Upadhyay et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are heterogeneous and potentially fatal consequences of serious conditions such as trauma and sepsis, an exacerbated inflammatory response to infection. There are no eff...
Science Under Siege [0.03%]
饱受攻击的科学
Kelsey Hills-Dunlap,David A Schwartz
Kelsey Hills-Dunlap
Macrophage CCL18 Promotes Lung Inflammation in Checkpoint Inhibitor Pneumonitis [0.03%]
巨噬细胞CCL18促进免疫检查点抑制剂引起的肺炎症
Mohammad I Ghanbar,Andres Villabona-Rueda,Nicolas Philip et al.
Mohammad I Ghanbar et al.
Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of immune checkpoint immunotherapy, characterized by acute lung injury leading, in severe cases, to hypoxic respiratory failure and death. CIP incidence in lung cancer i...