Chromatin Landscapes of Human Lung Cells Predict Potentially Functional Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Variants [0.03%]
基于人类肺细胞染色质景观的慢性阻塞性肺疾病全基因组关联研究位点的功能预测
Christopher J Benway,Jiangyuan Liu,Feng Guo et al.
Christopher J Benway et al.
Genome-wide association studies (GWASs) have identified dozens of loci associated with risk of chronic obstructive pulmonary disease (COPD). However, identifying the causal variants and their functional role in the appropriate cell type rem...
Reuse of Cell Culture Inserts for In Vitro Human Primary Airway Epithelial Cell Studies [0.03%]
体外人原代气道上皮细胞研究中细胞培养插入物的重复使用
Takafumi Kato,Yu Mikami,Ling Sun et al.
Takafumi Kato et al.
Capillary Changes Precede Disordered Alveolarization in a Mouse Model of Bronchopulmonary Dysplasia [0.03%]
早产肺发育不全小鼠模型中毛细血管改变先于肺泡发育异常出现
Svenja V Appuhn,Sara Siebert,Despoina Myti et al.
Svenja V Appuhn et al.
Bronchopulmonary dysplasia (BPD), the most common sequela of preterm birth, is a severe disorder of the lung that is often associated with long-lasting morbidity. A hallmark of BPD is the disruption of alveolarization, whose pathogenesis is...
A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples [0.03%]
一种重组的人肺表面活性物质蛋白D片段能够结合刺突蛋白并抑制SARS-CoV-2在临床样本中的感染和复制
Taruna Madan,Barnali Biswas,Praveen M Varghese et al.
Taruna Madan et al.
Coronavirus disease (COVID-19) is an acute infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human SP-D (surfactant protein D) is known to interact with the spike protein of SARS-CoV, but its imm...
Exploring the Influence of Cigarette Smoke on TROP2 Expression in Chronic Obstructive Pulmonary Disease [0.03%]
探究烟草烟雾对慢性阻塞性肺疾病TROP2表达的影响
Serena Di Vincenzo,Elisabetta Pace
Serena Di Vincenzo
Ana I Hernandez Cordero,Don D Sin
Ana I Hernandez Cordero
Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth Muscle adh5 [0.03%]
支气管肺发育不良和肺动脉高压 α平滑肌动蛋白的作用
Thomas M Raffay,Koby Bonilla-Fernandez,Anjum Jafri et al.
Thomas M Raffay et al.
Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification, airway hyperreactivity, and pulmonary hypertension. In our BPD model, we have investigated the metabolism of the bronchodilator and pulmonary vasodilator GSNO (S-...
Cristina Rodríguez,Neus Luque,Isabel Blanco et al.
Cristina Rodríguez et al.
COVID-19 and Coagulopathy [0.03%]
新冠肺炎与凝血障碍
Ken-Ichiro Inoue,Tomoya Sagawa,Hirohisa Takano
Ken-Ichiro Inoue
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression [0.03%]
Kindlin-2作为肺纤维母细胞活化及肺纤维病进展关键介导因子的作用
Ping Zhang,Jiaxin Wang,Weiren Luo et al.
Ping Zhang et al.
Pulmonary fibrosis is a progressive and fatal lung disease characterized by activation of lung fibroblasts and excessive deposition of collagen matrix. We show here that the concentrations of kindlin-2 and its binding partner PYCR1, a key e...