Metabolic alterations in cystic fibrosis lymphocyte memory accompanies restoration of CFTR function [0.03%]
Milene T Saavedra,Noel M Rysavy,Katie E Poch et al.
Milene T Saavedra et al.
Rationale: Elexacaftor-tezacaftor-ivacaftor (ETI) broadly improves outcomes in cystic fibrosis (CF). Cystic fibrosis transmembrane conductance regulator (CFTR) correction by ETI is incomplete, and patients with establishe...
Mitochondrial dysfunction due to myeloid TFAM loss limits senolytic efficacy in allergic airway inflammation [0.03%]
由于髓样TFAM损失引起的线粒体功能障碍限制了过敏性气道炎症中的杀老细胞效力
Jackie Nguyen,Courtney Van,Zianne A Olverson et al.
Jackie Nguyen et al.
Rationale: Macrophages are key drivers of allergic airway inflammation, but the mitochondrial mechanisms regulating these responses remain incompletely defined. Mitochondrial transcription factor A (TFAM) is essential for...
Michael Shlossman,Daniel P Cook
Michael Shlossman
Beyond Slowing Decline: Leveraging Apoptotic Synergy to Reverse Pulmonary Fibrosis [0.03%]
超越减缓衰弱：利用凋亡协同作用逆转肺纤维化
Yohannes A Mebratu,Jeffrey C Horowitz
Yohannes A Mebratu
Niyati A Borkar,Andrew J Halayko
Niyati A Borkar
Retrospective Analysis Reveals the Early Origin and Development of Pulmonary Perivascular Cells [0.03%]
回溯分析揭示肺血管周围细胞的早期起源和发育过程
Isabel I Sreeram,Beatrice Tan,Ruben G Boers et al.
Isabel I Sreeram et al.
The pulmonary vasculature develops in close association with the airways and this network expands through the interactions between endothelial cells and the surrounding mesenchymal cells, the pericytes. Emerging evidence suggests that peric...
Recurrent H1N1 Influenza A virus infections cause airway hyperinnervation and cough hypersensitivity via the IFN-γ-JAK-ERK1/2-CDK5 pathway [0.03%]
季节性H1N1病毒的反复感染通过IFN-γ-JAK-ERK1/2-CDK5信号通路诱导气道神经重塑和咳嗽高敏反应
Zheng Deng,Dongting Xu,Zhengyang Lin et al.
Zheng Deng et al.
Rationale: Chronic cough patients present with increased airway sensory nerve density-a pathology often initiated by recurrent viral infections, notably H1N1. Infection-induced IFN-γ acts via its highly expressed recepto...
E Protein-Driven iNKT Subset Modulation Shapes Early Immune Responses during Influenza a Virus Infection [0.03%]
流感病毒感染早期E蛋白驱动的iNKT亚群调节塑形早期免疫反应
Justyna Luczak,Oliwia Milek,Hannah Carter et al.
Justyna Luczak et al.
Invariant natural killer T (iNKT) cells play a critical role in the early phases of the response to Influenza A virus (IAV) infection by influencing inflammation and immune regulation, but the impact of the different iNKT functional subsets...
Amina Jouida,Michael P Keane,Cormac McCarthy
Amina Jouida
Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that predominantly affects women, particularly during their reproductive years. It is characterised by the proliferation of abnormal smooth muscle-like cells that infiltrate...