High-Mannose N-Glycans To Monitor Early Response to Chemotherapy in African Epithelial Ovarian Cancer Patients─A Pilot Study [0.03%]
高甘露糖N-聚糖作为化疗早期反应标志物在非洲上皮卵巢癌患者中的初步研究
Francis M Wanyama,Obinna Umeh,Karina Biskup et al.
Francis M Wanyama et al.
Epithelial ovarian cancer (EOC) remains the most lethal form of cancer despite improvements in surgical techniques and therapeutic interventions over recent decades. The high mortality rate is largely associated with a lack of sensitive and...
Serum Omics Analysis Reveals Tissue Damage and Metabolic Reprogramming in Cavitary Pulmonary Tuberculosis [0.03%]
血清组学分析揭示了空洞型肺结核的组织损伤和代谢重塑现象
Jianhai Wang,Dong Zhang,Chunnan Du et al.
Jianhai Wang et al.
Cavitary pulmonary tuberculosis (cPTB) is the most destructive manifestation of Mycobacterium tuberculosis infection and is associated with poor treatment response and high transmissibility. To capture the systemic disturbances that accompa...
Exploratory Serum Metabolomic Profiling of Asymptomatic Malaria Children Infected with Plasmodium falciparum in Tanzania [0.03%]
坦桑尼亚恶性疟原虫无症状感染儿童的血清代谢组学研究
Maria Mgella Zinga,Moussa Kassim Mohamed,Dupe Ojo et al.
Maria Mgella Zinga et al.
Asymptomatic Plasmodium falciparum infections are prevalent in malaria-endemic regions, yet their metabolic consequences remain poorly understood. In this exploratory study, we investigated the serum metabolomic profiles of 48 asymptomatic ...
Temporal Dynamics of the Milk Proteome in Women with Gestational Diabetes Mellitus [0.03%]
妊娠糖尿病女性乳蛋白组学的时间动态变化规律
Qier Mu,Yuanli Luo,Wei Li et al.
Qier Mu et al.
Objectives: To characterize the temporal dynamics of the breast milk proteome between women with gestational diabetes mellitus (GDM) and healthy controls across various lactation periods and to explore the potential impacts of these proteom...
Advancing Blood Proteome Analysis Past the Plasma Age: Mass Spectrometry of Whole Blood and Plasma Collected with Volumetric Absorptive Microsampling Devices [0.03%]
超越血浆时代的血液蛋白质组分析研究：全血和采用体积吸收式微采样装置收集的血浆的质谱分析
Elisabeth Karsten,Natasha Lucas,Cameron Hill et al.
Elisabeth Karsten et al.
Mass spectrometry-based proteomics of blood faces significant challenges due to the high dynamic range of proteins, with abundant proteins masking detection of low-abundance biomarkers. This study evaluated a novel volumetric absorptive mic...
The Clinical Prognostic Value of Lactylation-Regulated Proteins in Gastric Cancer [0.03%]
乳酰化调节的蛋白质在胃癌临床预后价值中的作用
Chenhao Fu,Zhifang Jia,Yingli Fu et al.
Chenhao Fu et al.
Gastric cancer (GC) is a leading cause of cancer-related mortality globally. Histone lactylation, an emerging post-translational modification, holds promise as a therapeutic target and prognostic biomarker, though its expression patterns an...
Untargeted Metabolomics for Wheat Bread In Vitro Digestate Assessment [0.03%]
未靶向代谢组学在小麦面包体外消化产物评估中的应用
Houssein Zhour,Mélanie Pétéra,Delphine Centeno et al.
Houssein Zhour et al.
Metabolomics is a powerful approach for investigating mechanisms linked to specific diseases or for exploring nutrition and health interaction. It is also recognized as a mature phenotyping tool for identifying diagnostic or prognostic biom...
Impact of PPP1R1A Knockdown on the Proteomic Landscape of INS-1 Cells: A Focus on Significant Modulated Pathways [0.03%]
PPP1R1A敲低对INS-1细胞蛋白质组的影响及重要通路的改变
Jalal Taneera,Alexander D Giddey,Nelson C Soares et al.
Jalal Taneera et al.
PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A) is a cAMP/PKA-responsive inhibitor of protein phosphatase 1 (PP1) with a pivotal role in pancreatic β-cell physiology. To investigate its functional impact, Ppp1r1a was silenc...
Multiplex Immune Profiling Reveals the Role of Serum Immune Proteomics in Predicting Response to Radioiodine after Total Resection of Papillary Thyroid Carcinoma [0.03%]
多重免疫特征分析揭示了血清免疫蛋白质组学预测乳头状癌甲状腺全切术后碘治疗反应的作用
Wanshu Peng,Shujing Li,Jiaxin Cao et al.
Wanshu Peng et al.
Radioactive iodine therapy (RAIT) is a common postsurgery treatment for papillary thyroid carcinoma (PTC), but some patients respond poorly. This study aimed to develop a noninvasive serological assay to predict RAIT efficacy. We examined l...
Proteomic Characterization of Spodoptera frugiperda granulovirus Occlusion Bodies [0.03%]
秋粘虫颗粒体病毒包涵体的蛋白质组学特征分析
Tomás Masson,María Laura Fabre,Santiago Gómez Bergna et al.
Tomás Masson et al.
Lepidopteran-infecting baculoviruses represent one of the most promising alternatives for pest biocontrol. In particular, Spodoptera frugiperda granulovirus (SfGV) infects the fall armyworm Spodoptera frugiperda, an increasingly important p...