Anesthesia-induced developmental neurotoxicity in the setting of systemic inflammation: the role of microglia [0.03%]
全身性炎症条件下麻醉诱导的发育神经毒性：小胶质细胞的作用
Nemanja Useinovic,Adre Newson,Michelle Near et al.
Nemanja Useinovic et al.
Although it is well documented in animal research that an early exposure to general anesthetics during critical stages of synaptogenesis disturbs normal brain development ultimately leading to cognitive and affective impairments, it is less...
In vivo silencing of the thalamic CaV3.1 voltage-gated calcium channels demonstrates their region-specific role in anesthetic mediated hypnosis [0.03%]
活体敲低丘脑CaV3.1电压门控钙离子通道表现出其在麻醉药物诱导镇静中的区域特异性作用
Tamara Timic Stamenic,Simon Feseha,Brier Fine-Raquet et al.
Tamara Timic Stamenic et al.
Although substantial progress has been made in the last three decades towards our understanding of how general anesthetics (GAs) act at the molecular level, much less is known about how GAs cause loss of consciousness at the level of neuron...
α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala [0.03%]
亚麻仁籽酸通过基底外侧杏仁核中的酸感应离子通道（ASIC1a）活性促进GABA能突触传递作用
Volodymyr I Pidoplichko,Taiza H Figueiredo,Maria F M Braga et al.
Volodymyr I Pidoplichko et al.
Epilepsy affects more than 70 million people worldwide. A seizure focus that develops in different cortical brain regions can present as either focal or generalized seizures. Temporal lobe epilepsy is a highly pharmacoresistant form of epil...
Involvement of EGFR-AKT signaling in hemin-induced neurotoxicity [0.03%]
血红素诱导的神经毒性的EGFR-AKT信号通路参与作用研究
Hui-Ju Huang,Yang-Jie Tseng,I-Jung Lee et al.
Hui-Ju Huang et al.
Intracerebral hemorrhage (ICH), as bleeding from ruptured vessels within the brain, is the second leading neuropathological problem following ischemic stroke. In the present study, the involvement of epithelial growth factor receptor (EGFR)...
Vaccination with synthetic long peptide and CpG 2395 in AddaVax induces potent anti-tumor effects [0.03%]
合成长肽联合CpG 2395和Addavax疫苗对肿瘤的治疗效果
Shanshan Jiang,Shuqi Zhao,Qiaojiajie Zhao et al.
Shanshan Jiang et al.
Cancer/testis antigen HCA587, also known as MAGE-C2, highly expressed in a wide range of malignant tumors with unique immunological characteristics, serves as a potential target for tumor immunotherapy. Synthetic long peptides from HCA587 (...
A refined set of RxNorm drug names for enhancing unstructured data analysis in drug safety surveillance [0.03%]
改进的RxNorm药物名称集在药品安全性监测中增强非结构化数据分析的能力
Wenjing Guo,Fan Dong,Jie Liu et al.
Wenjing Guo et al.
Adverse drug events are harms associated with drug use, whether the drug is used correctly or incorrectly. Identifying adverse drug events is vital in pharmacovigilance to safeguard public health. Drug safety surveillance can be performed u...
Detection of respiratory syncytial virus based on RT-RPA and CRISPR-Cas12a [0.03%]
基于RT-RPA和CRISPR-Cas12a的呼吸道合胞病毒检测方法
Ariya Khamwut,Juthamas Nimnual,Nantinee Chomta et al.
Ariya Khamwut et al.
Human respiratory syncytial virus (hRSV) is one of the most prevalent viruses infecting children globally. In this study, we employed the RT-RPA with CRISPR/Cas12a detection methodology to detect and differentiate RSV-A and RSV-B, particula...
Pan-immune-inflammation value predicts survival in inflammatory breast cancer patients [0.03%]
泛免疫炎症值可预测炎性乳腺癌患者的生存率
Yingjia Hu,Jian Li,Mingyu Wang et al.
Yingjia Hu et al.
Inflammatory breast cancer (IBC) is a rare and aggressive breast cancer subtype with poor survival. Identifying novel biomarkers is needed to predict survival for this highly progressive form of breast cancer. In this retrospective study, w...
Critical role of alpha spectrin in DNA repair: the importance of μ-calpain and Fanconi anemia proteins [0.03%]
α-谱蛋白在DNA修复中的关键作用：μ-Calpain和Fanconi贫血症蛋白的重要性
Muriel W Lambert
Muriel W Lambert
Nonerythroid spectrins are proteins important in maintaining the structural integrity and flexibility of the cell and nuclear membranes and are essential for a number of functionally important cellular processes. One of these proteins, none...
Aberrant DNMT1-mediated DACH1 methylation is associated with colorectal adenoma-to-carcinoma progression [0.03%]
DNMT1介导的DACH1异常甲基化与结直肠腺瘤癌变有关
Yan Zhang,Honggang Liu
Yan Zhang
Colorectal cancer (CRC) remains a major contributor to cancer-related morbidity and mortality. While Dachshund homolog 1 (DACH1) was recognized as a critical regulator in cancer progression, its role in promoting or suppressing tumor develo...