Towards a standardized diabetic prolonged wound healing model in hairless SKH1 mice [0.03%]
用于无毛SKH1小鼠的糖尿病长期伤口愈合模型标准化研究进展
Elle Koivunotko,Julia Monola,Chris S Pridgeon et al.
Elle Koivunotko et al.
Chronic wounds, particularly those associated with diabetes, pose a significant clinical challenge due to their impaired healing dynamics and lack of reliable and standardized preclinical models. This pilot study aimed to establish a diabet...
A novel platelet-rich plasma clinically induces reliable, rapid, long-term chronic peripheral neuropathic pain elimination [0.03%]
一种新型富含血小板血浆可有效治疗慢性外周神经病理性疼痛
Damien P Kuffler,Onix Reyes,Ivan J Sosa et al.
Damien P Kuffler et al.
Peripheral nerve trauma results in 50%-84% of patients developing chronic neuropathic pain, which is eliminated when axons reinnervate targets. Autografts reduce pain by promoting target reinnervation. We hypothesized that applying a novel ...
Enhanced oxidative stress resilience in C. elegans acox-1.1 mutants through CTL-3 and proteasomal regulation [0.03%]
通过CTL-3和蛋白酶体调控增强线虫acoix-1.1突变体的氧化应激抗性
Woori Bae,Mina Norman,Myon Hee Lee
Woori Bae
Oxidative stress is a primary driver of aging, necessitating robust cellular adaptation mechanisms. While peroxisomal β-oxidation and proteasomal degradation are known to influence stress responses, their functional crosstalk remains elusi...
Low dose thirdhand smoke exposure enhances platelet functional responses in mice [0.03%]
低剂量三手烟暴露可增强小鼠血小板功能反应
Precious O Badejo,Ahmed B Alarabi,Hamdy E A Ali et al.
Precious O Badejo et al.
Although cigarette smoking is the most preventable cause of cardiovascular diseases, most researchers have focused on either direct/firsthand or secondhand smoke exposures. Recently though, attention has shifted to an emerging/indirect expo...
Metabolomics-guided identification of bioactive phytometabolites from South African plants targeting neuroblastoma [0.03%]
基于代谢组学的南非植物源神经母细胞瘤靶向活性次生代谢产物的研究
Mmei Cheryl Motshudi,Clarissa Marcelle Naidoo,Chikwelu Lawrence Obi et al.
Mmei Cheryl Motshudi et al.
Neuroblastoma constitutes a solid tumor in pediatric populations, characterized by a dismal prognosis and a scarcity of effective therapeutic interventions. Medicinal flora from South Africa represents valuable sources of bioactive phytomet...
Global MyoG research 2004-2024: a bibliometric analysis of trends and translational implications [0.03%]
2004-2024年全球MYOG研究的文献计量分析：发展趋势与转化意义
Luoming Hu,Weizhong Zhuang,Weimin Chen et al.
Luoming Hu et al.
Myogenin (MyoG) is a core myogenic transcription factor that orchestrates myoblast differentiation and myofiber maturation and has been increasingly implicated in skeletal muscle degeneration and rhabdomyosarcoma, yet its global research la...
A novel de novo ATP2B1 variant causes autosomal dominant intellectual developmental disorder 66 by disrupting calcium homeostasis via impaired membrane trafficking [0.03%]
新的ATP2B1变异通过干扰膜转运破坏钙稳态引起常染色体显性智力发育障碍66型
Huanhuan Zang,Xiaoyun Yang,Yucai Liu et al.
Huanhuan Zang et al.
Heterozygous pathogenic variants in ATP2B1 (encoding PMCA1) cause autosomal dominant intellectual developmental disorder 66 (MRD66; OMIM #619910). To date, only 12 pathogenic de novo ATP2B1 variants have been reported in MRD66. This study a...
Ananalysis of the effects of Treg cell therapy intervention on the gut microbiota of type 1 diabetic mice using 16S rRNA gene sequencing [0.03%]
基于16S rRNA基因测序技术分析调节性T细胞治疗干预对1型糖尿病小鼠肠道菌群的影响
Mengyao Zhou,Kang Du,Hanmin Wang et al.
Mengyao Zhou et al.
This study established a type 1 diabetes (T1DM) mouse model via intraperitoneal injection of streptozotocin (STZ) and examined the effect of regulatory T (Treg) cells on the gut microbiota by comparing its composition and diversity across t...
Skeletal muscle reprogramming in peripheral nerve injury: mechanisms, therapeutic roles, and complication management [0.03%]
外周神经损伤中的骨骼肌重编程：机制、治疗作用和并发症管理
Fuqiang Long,Xiaoru Pan,Anxin He et al.
Fuqiang Long et al.
Peripheral nerve injury (PNI) presents a significant clinical challenge, frequently leading to long-term neuromuscular dysfunction, muscle atrophy, fibrosis, and chronic pain. Traditional repair strategies, including microsurgical reconnect...
Identification of potential hub genes related to ferroptosis and hypoxia in dilated cardiomyopathy: a bioinformatic analysis with preliminary experimental validation [0.03%]
缺血性心肌病相关铁死亡和低氧潜在枢纽基因的生物信息学筛选及初步实验验证
Xiqin Wang,Chrismis Novalinda Ginting,William Leslie
Xiqin Wang
The study aims to explore the potential role of ferroptosis and hypoxia in dilated cardiomyopathy (DCM). GSE120895, GSE17800, GSE112556, ferroptosis-related genes (FRGs), and hypoxia-related genes (HRGs) were downloaded from the public data...