Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform [0.03%]
可扩展的人类肝微生理系统：实施更高通量的肝小叶微生理系统平台
Dillon C Gavlock,Michael W Castiglione,Allen Wang et al.
Dillon C Gavlock et al.
The advancement in the use of all-human high content microphysiological systems (MPS) has enabled better in vitro modeling of liver function and disease progression as well as drug efficacy, metabolism and toxicity (ADME-Tox) testing. Howev...
Race, oxygen exposure, and retinopathy of prematurity: re-examining a persistent epidemiologic paradox [0.03%]
种族、氧气暴露与早产儿视网膜病变：重新审视一个持续存在的流行病学悖论
Beryl Zhou,Sarah H Rodriguez,Alexis Warren et al.
Beryl Zhou et al.
Retinopathy of prematurity (ROP) is a leading cause of childhood blindness that arises from disrupted retinal vascular development in premature infants. Oxygen exposure remains a central driver of treatment-warranted ROP, as higher saturati...
Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis [0.03%]
外周免疫细胞和糖基化指标作为肌萎缩侧索硬化诊断生物标志物的潜力
Xue Yang,Jing Yang,Rui Li et al.
Xue Yang et al.
The diagnosis of amyotrophic lateral sclerosis (ALS) mainly relies on clinical symptoms and the exclusion of other diseases, with a lack of specific biomarkers, leading to delayed diagnosis and a high rate of misdiagnosis. This study aims t...
Antibody-mediated immune responses and cardiovascular disease: a Mendelian randomization study [0.03%]
基于孟德尔随机化研究的抗体介导的免疫反应与心血管疾病的关系
Yi Li,Jiuqi Fan,Lirong Wu
Yi Li
Cardiovascular diseases represent the leading cause of global mortality and disability, posing a severe threat to human health. Accumulating evidence suggests that antigen-antibody-mediated immune responses may be involved in the pathogenes...
Causal relationship between oral diseases and hypertension: a Mendelian randomization study [0.03%]
口腔疾病和高血压之间的因果关系：一项孟德尔随机化研究
Bofan Qian,Zhiwen Fang
Bofan Qian
Current evidence supports the potential association between several common oral diseases and hypertension. The aim of the research is to clarify the causal relationship between these oral diseases and hypertension using Mendelian randomizat...
Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions [0.03%]
急性缺血性卒中机械取栓术后再灌注铁死亡及无效再通的机制、风险因素、预测模型与治疗干预措施
Yuexin Wu,Cuiying Zhang,Yangyang Peng et al.
Yuexin Wu et al.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability worldwide. Endovascular mechanical thrombectomy (EVT) has revolutionized stroke treatment by enabling rapid recanalization of occluded cerebral vessel...
Sacubitril valsartan combined with bisoprolol reduces doxorubicin-induced cardiotoxicity in rats by attenuating oxidative stress [0.03%]
沙库必利 valsartan 联合比索洛尔通过减轻氧化应激降低多柔比星诱导的大鼠心脏毒性
Ping Liu,Hui Yang,Runqi Li et al.
Ping Liu et al.
Doxorubicin-induced cardiotoxicity remains a leading cause of mortality among cancer patients, with oxidative stress serving as a central pathogenic mechanism. This study investigated whether combination therapy with sacubitril valsartan an...
Training the next-generation of biomedical scientists through artificial intelligence-driven education and research in pharmacology and pharmaceutical sciences [0.03%]
通过人工智能驱动的药理学和药物科学教育和研究培养下一代生物医学科学家
Santosh Kumar,Ritu Karwasra,Weinan Zhou et al.
Santosh Kumar et al.
Artificial intelligence (AI)-driven graduate education and research in pharmacology and pharmaceutical sciences (AIPPS) aims to address the rapidly-growing role of AI and machine learning (ML) applications in biomedical sciences. This revie...
Elevated ApoC3 levels in cerebrospinal fluid predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage [0.03%]
脑脊液中升高的ApoC3水平可预测动脉瘤性蛛网膜下腔出血患者的预后不良
Bin Tong,Junjie Wang,Jiarui Chen et al.
Bin Tong et al.
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating condition associated with approximately 30% mortality and 20% severe disability among survivors. Delayed cerebral ischemia due to cerebral vasospasm and hydrocephalus significantly ...
Elizabeth Hogben,Anna Schurich,Charlotte Graham
Elizabeth Hogben
For the treatment of many forms of cancer, cell- and gene-based therapies are showing promise in both pre-clinical data and clinical trials. In particular, CAR T cell therapies, of which there are now 7 FDA-approved products, have shown gro...