Multi-omics analysis identifies the unique high-FDCSP basal cells in triple-negative breast cancer [0.03%]
多组学分析识别出三阴性乳腺癌中独特的高FDCSP基底细胞
Xinya Lu,Zhen Chen,Ying Shao
Xinya Lu
Follicular dendritic cell secreted protein (FDCSP) is highly expressed in various cancers and has been implicated in tumor migration and invasion, yet its role in triple-negative breast cancer (TNBC) remains poorly understood. Our findings ...
Platelet-rich plasma in peripheral nerve injury repair: a comprehensive review of mechanisms, clinical applications, and therapeutic potential [0.03%]
富血小板血浆在周围神经损伤修复中的作用：机制、临床应用和治疗潜力的全面综述
Kai Shang,Yang Liu,Abdul Qadeer
Kai Shang
Peripheral nerve injuries (PNIs) pose a significant clinical challenge, often leading to incomplete functional recovery despite current treatments. Platelet-rich plasma (PRP), which contains high levels of growth factors and bioactive molec...
Variational autoencoder enhanced analysis of energy metabolism and autophagy in exercising cardiomyocytes [0.03%]
变自动机编码增强型能量代谢和自噬在运动心肌细胞中的分析
Liquan Chen,Yun Yang
Liquan Chen
Autophagy of myocardial cells involves the interaction of multiple molecular signaling pathways, and regulatory factors, while existing methods are difficult to handle. This study utilized the variational autoencoder (VAE) model to reveal t...
A case study of long-term disease burden in a rural community near an open burn facility [0.03%]
邻近开放焚烧设施的农村社区长期疾病负担案例研究
Arundhati Bakshi,Liana Baconguis,Md Abdullah Al-Mamun et al.
Arundhati Bakshi et al.
Open burning and open detonation (OB/OD) of explosive and hazardous wastes creates various toxic waste products, including particulate matter, that is released into the atmosphere and capable of generating significant health impacts upon ex...
Prognostic significance and therapeutic implications of redox metabolism-related genes in head and neck squamous cell carcinoma [0.03%]
头颈部鳞状细胞癌中与氧化代谢相关基因的预后意义及治疗启示
Lina Yang,Jingyu Hai,Jiayi Liu et al.
Lina Yang et al.
Head and neck squamous cell carcinomas (HNSC) are associated with alterations in redox metabolism. This study aims to identify differentially expressed genes (DEGs) related to redox metabolism in HNSC and assess their prognostic values. We ...
Unraveling the pharmacological and therapeutic potential of Ranolazine beyond antianginal drug use: a new insight [0.03%]
兰索拉唑的药理和治疗潜力研究——不仅限于抗心绞痛药物：新视角
Dhirendra Singh,Joy Awulika Oladimeji-Salami,Abidemi James Akindele
Dhirendra Singh
Ranolazine (RAN) is an acetanilide and piperazine derivative that selectively blocks the late sodium current in cardiac cells and is prescribed in adults as an add-on medication for the symptomatic management of patients with stable angina ...
An approach to evaluate the effect of inflammatory microvesicles on Ca2+ handling in human-induced pluripotent stem cell-derived cardiomyocytes [0.03%]
评估炎症微囊对人诱导多能干细胞源性心肌细胞钙处理影响的方法研究
Dania Fischer,Mishkaat Sha&#x;sha&#x;a,Judith Schenz et al.
Dania Fischer et al.
Microvesicles (MV) isolated from septic individuals were observed to impact systemic hemodynamics and cardiac function. The aim of this in vitro study was to analyze the effects of TNFα-induced endothelial MV (TMV) and MV from septic patie...
RNA binding proteins potentially regulate alternative splicing of immune-related genes during the progression of coronary artery disease [0.03%]
冠心病进展期间与免疫相关的基因的可变剪接潜在地受到RNA结合蛋白的调节
Yulin Miao,Lei Wang,Gang Zhao et al.
Yulin Miao et al.
RNA-binding proteins (RBPs) are crucial in disease as they regulate the biological functions of RNA. However, their role in coronary artery disease (CAD) progression remains unclear. RNA-seq from peripheral blood of CAD patients and no-CAD ...
Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism [0.03%]
钠丙戊酸诱导的自闭症小鼠模型中的代谢组和微生物组综合分析
Shuzhen Zhao,Xinyan Zhang,Yanqiu Miao et al.
Shuzhen Zhao et al.
Sodium valproate (SV) has been shown to induce autism in animal models. In this study, the SV method was used to establish a mouse model of autism, and anxiety-like behaviours and learning memory performance were evaluated by behavioural te...
Association between systemic immune-inflammation index and 10-year risk of cardiovascular disease in the United States (NHANES 1999-2018) [0.03%]
美国（1999-2018年全国健康和营养检查调查）系统性免疫炎症指数与心血管疾病10年发病风险的相关性研究
Yapan Yang,Runqi Tu,Lijie Zhu et al.
Yapan Yang et al.
The relationship between the systemic immune-inflammation index (SII) and the risk of developing cardiovascular disease (CVD) over the next 10 years in the United States is largely unknown. The aim of this study is to assess the association...