Beginning of a new era of synthetic messenger RNA therapeutics: Comprehensive insights on mRNA drug design, development and applications [0.03%]
合成信使RNA治疗新时代的开始——关于mRNA药物设计、开发和应用的全面见解
Saumya Nishanga Heendeniya,Suxiang Chen,Saadia Bhatti et al.
Saumya Nishanga Heendeniya et al.
Messenger RNA (mRNA) therapeutics have significantly transformed contemporary medicine, particularly through their role as the active component in the SARS-CoV-2 vaccine. This remarkable achievement is the culmination of extensive research ...
Neutrophil extracellular traps: emerging drivers and therapeutic targets in abdominal aortic aneurysm pathogenesis [0.03%]
中性粒细胞胞外陷阱：腹主动脉瘤发病机制中的新兴驱动因素和治疗靶点
Xinyi Lyu,Qi Liu,Jiahao Shi et al.
Xinyi Lyu et al.
Abdominal aortic aneurysm (AAA) is a life-threatening condition with no effective pharmacological treatments, underscoring the critical need to identify novel therapeutic targets. Emerging translational and clinical evidence implicates neut...
LncRNA HOTAIR promotes LPS-induced inflammatory responses by activating the NF-κB pathway [0.03%]
长链非编码RNA HOTAIR通过激活NF-κB途径促进LPS诱导的炎症反应
Fengqing Zhu,Zexun Mo,Wuzhou Lin et al.
Fengqing Zhu et al.
Acute lung injury (ALI) is a disease with an excessive inflammatory response triggered by activating the NF-κB signaling pathway. Our study aims to investigate the role of the long non-coding RNA HOTAIR in ALI-associated hyperinflammation,...
Diet-lifestyle oxidative balance in relation to cardiometabolic multimorbidity: findings from the national health and nutrition examination survey [0.03%]
来自全国健康和营养检查调查的心血管代谢多发病与饮食生活方式氧化平衡的关系
Wenrui Shi,Yu Zhao,Jieun Park et al.
Wenrui Shi et al.
Oxidative stress is a critical factor in the development of cardiometabolic diseases. The Oxidative Balance Score (OBS), integrating dietary and lifestyle factors, has been proposed as a measure of the balance between pro-oxidants and antio...
Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats [0.03%]
小檗碱-CS/SLE纳米粒对链脲佐菌素致妊娠糖尿病大鼠的保护作用研究
Yu Liu,Shaik Althaf Hussain,Hua Yue
Yu Liu
Berberine, known as an antioxidant agent, can improve glycemic indices in animal models of diabetes; however, it is clinically limited by poor bioavailability. Nanoparticles show the desirable capacity as delivery platforms for improving th...
Chimeric antigen receptor natural killer cell therapy for solid tumors: mechanisms, clinical progress, and strategies to overcome the tumor microenvironment [0.03%]
嵌合抗原受体自然杀伤细胞治疗实体瘤：机制、临床进展和克服肿瘤微环境的策略
Yu Xiang,Jiayi Dong,Lijuan Shao et al.
Yu Xiang et al.
Natural killer (NK) cells represent a fundamental component of the innate immune system, endowed with the ability to identify and eradicate virus-infected and malignant cells. The advent of chimeric antigen receptor (CAR) technology has int...
Mapping microglial mechanisms in Alzheimer's disease: a comprehensive analysis [0.03%]
阿尔茨海默病的小胶质细胞机制的综合分析映射研究报告
Xiaofang Wang,Yuqing Guo,Yonghan Zha et al.
Xiaofang Wang et al.
Microglia, the brain's primary immune cells, play crucial roles in Alzheimer's disease (AD) pathogenesis. However, existing research remains abundant yet fragmented. Therefore, this study aimed to systematically identify hotspots and trends...
Peripheral artery disease and local drug delivery: a review of disease pathology and drug delivery systems for therapy below the knee [0.03%]
外周动脉疾病及局部给药：下肢药物递送系统治疗疾病的病理学回顾
Nicole M Akers,Tammy R Dugas
Nicole M Akers
Peripheral artery disease (PAD) is a disease of both atherosclerotic and thromboembolic pathology, affecting more than 230 million people globally. PAD patients are at an increased risk of thrombotic events and often require lifelong antith...
Clinical data comparison for FDA-approved gene therapies in sickle cell disease [0.03%]
FDA批准的治疗镰状细胞病基因疗法的临床数据比较
Alexis Leonard,Julie Kanter
Alexis Leonard
Sickle cell disease (SCD) is a severe inherited hemoglobinopathy with limited curative treatment options. In December 2023, the U.S. FDA approved two autologous gene therapies, lovo-cel (bluebird bio) and exa-cel (Vertex/CRISPR Therapeutics...
ApoE COG 133 mimetic peptide improves survival, infection burden, and Clostridioides difficile toxin-A-induced intestinal damage in mice [0.03%]
APOE COG133 样肽改善小鼠的存活率、感染负担和艰难梭菌毒素A诱导的肠道损伤
Orleâncio G R de Azevedo,Jae H Shin,Rosemayre S Freire et al.
Orleâncio G R de Azevedo et al.
Apolipoprotein E (ApoE = protein; APOE = gene), a lipid carrier that modulates inflammatory responses, may influence Clostridioides difficile (C. difficile) infection (CDI) outcomes. We explored the role of the APOE gene using apoE-deficien...