Michael R Wiederkehr,Orson W Moe
Michael R Wiederkehr
Uric acid nephrolithiasis is characteristically a manifestation of a systemic metabolic disorder. It has a prevalence of about 10% among all stone formers, the third most common type of kidney stone in the industrialized world. Uric acid st...
Briana Mezuk
Briana Mezuk
The nature of the relationship between affective disorders, bone mineral density (BMD), and bone metabolism is unresolved, although there is growing evidence that many medications used to treat affective disorders are associated with low BM...
Shane A J Lloyd,Henry J Donahue
Shane A J Lloyd
Communication between osteoblasts, osteoclasts, and osteocytes is integral to their ability to build and maintain the skeletal system and respond to physical signals. Various physiological mechanisms, including nerve communication, hormones...
Kathryn M Thrailkill,John L Fowlkes
Kathryn M Thrailkill
Most studies across a variety of geographic locations suggest that vitamin D insufficiency is more common in individuals with type 1 diabetes (T1D) compared to the general population. In type 2 diabetes (T2D), while obesity is commonplace a...
Beata Lecka-Czernik
Beata Lecka-Czernik
Osteoporosis and diabetic disease have reached epidemic proportion and create significant public health concerns. The prevalence of these diseases is alarming, and indicates that in the US, 50% of elderly individuals are osteoporotic and al...
Ionizing Radiation and Bone Loss: Space Exploration and Clinical Therapy Applications [0.03%]
电离辐射与骨质流失：太空探索和临床治疗的应用
Jeffrey S Willey,Shane A J Lloyd,Gregory A Nelson et al.
Jeffrey S Willey et al.
Damage to normal, nontumor bone tissue following therapeutic irradiation increases the risk of fracture among cancer patients. For example, women treated for various pelvic tumors have been shown to have a greater than 65% increased inciden...
Naim Maalouf
Naim Maalouf
Nephrolithiasis is a prevalent and costly condition with high recurrence rate. A medical evaluation to identify abnormalities responsible for nephrolithiasis and guide subsequent therapy has been advocated to reduce the risk of stone recurr...
Cysteine Protease Cathepsins in Atherosclerosis and Abdominal Aortic Aneurysm [0.03%]
半胱氨酸蛋白酶猫途斯在动脉粥样硬化和腹部主动脉瘤中的作用
Sara Sjöberg,Guo-Ping Shi
Sara Sjöberg
Extracellular matrix remodeling is an important mechanism in the initiation and progression of cardiovascular diseases. Cysteine protease cathepsins are among the important proteases that affect major events in the pathogenesis of atheroscl...
Mechanisms of Stone Formation [0.03%]
结石形成的机制
Vishal N Ratkalkar,Jack G Kleinman
Vishal N Ratkalkar
Joseph P Bidwell,Fredrick M Pavalko
Joseph P Bidwell
We introduced the mechanosome hypothesis in 2003 as a heuristic model for investigating mechanotransduction in bone (Pavalko et al., J Cell Biochem, 2003, 88(1):104-112). This model suggested specific approaches for investigating how mechan...