Jing Su,Meiyuan Jin,Zengwu Shao et al.
Jing Su et al.
Malignant tumors of the distal tibia are rare and pose unique reconstructive challenges due to the region's complex anatomical and biomechanical characteristics. Contemporary treatment has progressively shifted from amputation to limb salva...
Update in the Management of ACTH-Secreting Gastroenteropancreatic and Thoracic Neuroendocrine Neoplasms [0.03%]
胃肠道胰神经内分泌肿瘤和类癌综合征的治疗进展
Marina Tsoli,Anat Bel-Ange,Karine Atlan et al.
Marina Tsoli et al.
The adrenocorticotropic hormone (ACTH)-secreting neuroendocrine neoplasms (NENs) represent a rare but frequently severe disease that is associated with poor prognosis, if not adequately managed. Treatment strategies vary according to the ch...
Dermatofibrosarcoma Protuberans (DFSP): Current Treatments and Clinical Trials [0.03%]
隆突性皮肤纤维肉瘤（DFSP）的当前治疗及临床试验
Piotr Remiszewski,Agata Pisklak,Kinga Filipek et al.
Piotr Remiszewski et al.
Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma with an incidence of 0.008 to 0.045 cases per 100,000 per year, accounting for less than 1% of all soft tissue sarcomas. It mainly affects adults aged 30-50 years, usually...
Dermatofibrosarcoma Protuberans (DFSP): Diagnostics and Molecular Pathology [0.03%]
突起型皮肤纤维组织细胞瘤(DFSP)的诊断及分子病理学
Piotr Remiszewski,Joanna Taczała,Marcin Rosiński et al.
Piotr Remiszewski et al.
Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade mesenchymal neoplasm that arises in the dermis and subcutaneous tissue. Clinically, DFSP presents as a slow-growing cutaneous plaque or nodular mass that is often initially mistake...
Advancing Bladder Cancer Management: The Role of Neoadjuvant and Adjuvant Therapies and Biomarkers in Muscle Invasive Bladder Cancer [0.03%]
肌层浸润性膀胱癌的新辅助和辅助治疗及生物标志物的作用对未来膀胱癌管理的影响
Lingbin Meng,Adam Khorasanchi,Rohit Jain
Lingbin Meng
The management of muscle-invasive bladder cancer (MIBC) is evolving rapidly, with the integration of neoadjuvant and adjuvant therapies and biomarker-driven patient selection now essential to refining treatment decisions. While cisplatin-ba...
PAI-1 in Skin Malignancies: a Central Regulator of Tumor Progression and Therapeutic Resistance [0.03%]
皮肤恶性肿瘤中的PAI-1：肿瘤进展和治疗抵抗的中枢调节因子
Taku Fujimura,Yoshihide Asano
Taku Fujimura
Plasminogen activator inhibitor-1 (PAI-1) plays a multifaceted and central role in the tumor biology of various skin malignancies. Beyond its classical function in fibrinolysis, PAI-1 contributes to tumor progression by promoting immunosupp...
Care of Older Adults with Acute Myeloid Leukemia: The Role of Geriatric Assessment [0.03%]
老年急性髓系白血病患者的护理：老年人评估的作用
Ojbindra Kc,Moataz Ellithi,Vijaya Raj Bhatt
Ojbindra Kc
Older adults with acute myeloid leukemia (AML) face disproportionately poor outcomes, driven by a combination of high-risk disease biology and functional vulnerabilities that are often overlooked by conventional oncology assessments. Geriat...
Perioperative Immune Checkpoint Inhibitors for the Treatment of Locally Advanced Gastric and Gastroesophageal Junction Cancer: Current Status and Future Prospects [0.03%]
perioperative免疫检查点抑制剂治疗局部晚期胃和胃食管交界处癌症：现状与未来展望
Siyuan Cui,Kui Zhao,Na Wang et al.
Siyuan Cui et al.
Novel strategies utilizing immune checkpoint inhibitors (ICIs) have emerged over the past several years and substantially changed the treatment landscape of advanced gastric cancer (GC). Based on the encouraging results achieved, numerous c...
From Fallopian Tube to Ovarian Cancer: Understanding the Evaluation and Management of Serous Tubal Intraepithelial Carcinoma Lesions [0.03%]
从输卵管癌到卵巢癌：认识浆液性输卵管上皮内癌病变的评估和处理方法
Vinita Popat,Ernest Han
Vinita Popat
Ovarian cancer, particularly high-grade serous carcinoma (HGSC), remains a leading cause of mortality in gynecologic oncology. Emerging research identifies serous tubal intraepithelial carcinoma (STIC) as a precursor lesion in many HGSC cas...
Immunotherapy in the Treatment of Undifferentiated Pleomorphic Sarcoma and Myxofibrosarcoma [0.03%]
未分化多形性肉瘤和黏液纤维肉瘤的免疫治疗
Jerry T Wu,Elizabeth Nowak,Jarrell Imamura et al.
Jerry T Wu et al.
Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are among the most common adult soft tissue sarcoma (STS) subtypes. Due to their high genetic complexity, heterogeneity, and lack of specific genetic alterations, no cons...