Daniel H Chen,Lloyd Butel-Simoes,Mitchum Bower et al.
Daniel H Chen et al.
Cardio-oncology is a rapidly evolving subspecialty at the intersection of cancer and cardiovascular disease (CVD), two of Australia's leading causes of morbidity and mortality. Advances in cancer detection and therapy have markedly improved...
Beyond CDK4/6 Inhibition: Current Strategies in Hormone Receptor-Positive Metastatic Breast Cancer [0.03%]
超越CDK4/6抑制作用：激素受体阳性转移性乳腺癌的当前策略
Bulent Cetin,Dilek Erdem,Irem Karaman et al.
Bulent Cetin et al.
We focus our second-line treatment strategy on biomarker-defined resistance mechanisms that emerge after progression on CDK4/6 inhibitors. In our view, ESR1 mutation–mediated resistance constitutes a biologically distinct phenotype of endo...
Advanced Mucosal Melanoma Therapies: Current Status and Future Directions [0.03%]
黏膜黑色素瘤的综合治疗：现状和未来方向
Yiqun Zhang,Dawei Zhao,Di Wu
Yiqun Zhang
Mucosal melanoma (MM) represents a rare malignancy in Caucasian populations but constitutes one of the predominant melanoma subtypes among non-Caucasian ethnic groups. Due to its anatomic occult nature, a significant proportion of patients ...
Theranostics in Sarcoma: A Critical Review of Current Evidence and Future Potential [0.03%]
软组织肉瘤诊疗现状及未来展望：批判性综述
Ojasvi Appana,David Konieczkowski,Gabriel Tinoco
Ojasvi Appana
Sarcomas are rare, heterogeneous malignancies with over 100 subtypes and limited effective therapies in advanced stages. Theranostics, a strategy that combines diagnostic imaging and targeted radionuclide therapy using the same molecular ta...
Whole Lung Irradiation in Ewing Sarcoma with Pulmonary Metastases: Critical Appraisal of Evolution, Evidence, and Future Pathways in Precision Oncology [0.03%]
肺转移的 ewing 肉瘤患者全身放疗：对进化、证据和精确诊断肿瘤学未来途径的批判性评估
YuanYou Yang,Lu Xie,Jie Xu et al.
YuanYou Yang et al.
Based on the cumulative evidence, we advocate for the continued use of whole lung irradiation (WLI) as an integral component of multimodal therapy for Ewing sarcoma patients with pulmonary metastases, particularly in those with isolated lun...
Menin Inhibitors: A New Era of Targeted Therapies in Acute Myeloid Leukemia [0.03%]
美坦辛抑制剂：急性髓系白血病靶向治疗的新时代
Daniel T Peters,Jess Hatfield,Mollie Reese et al.
Daniel T Peters et al.
Transforming a Roadblock into a Roadmap: Evolving HFSR Management From Adverse Event to Efficacy Biomarker [0.03%]
从不良事件到疗效生物标志物：HFSR管理演变之路
Qian Xu,Jinhan Chen,Huiwen Sun et al.
Qian Xu et al.
Whole Abdominal Radiotherapy in Bone and Soft Tissue Sarcomas: Indications, Techniques, Clinical Outcomes, and Future Directions [0.03%]
全身放射治疗在骨和软组织肉瘤中的应用：指征、技术、临床结果及未来方向
YuanYou Yang,Lu Xie,Xin Sun et al.
YuanYou Yang et al.
Managing bone and soft tissue sarcomas at high risk of intra-abdominal spread remains clinically challenging, and whole abdominal radiotherapy (WART) has become a pivotal locoregional component of multimodal therapy. For desmoplastic small ...
The Use of Targeted Therapy in Pediatric Acute Lymphoblastic Leukemia: Exploring Novel Approaches and Emerging Therapies [0.03%]
靶向治疗在儿童急性淋巴细胞白血病中的应用：探索新型方法和新兴疗法
David J Byrwa,Marissa Krieger,Lisa M Niswander et al.
David J Byrwa et al.
With modern risk stratification of multi-agent cytotoxic chemotherapy protocols, we now cure the majority of patients with pediatric acute lymphoblastic leukemia (ALL). However, patients with high-risk features or relapsed disease continue ...