Carlos H F Chan,Philip Wong
Carlos H F Chan
Soft-tissue sarcoma is one of the few clinical cancer models in which pre-operative radiotherapy is commonly utilized and in which tumor response to radiotherapy could be assessed. However, clinical and histopathological features of soft-ti...
Appropriate Recommendations for Surgical Debulking in Stage IV Ovarian Cancer [0.03%]
Ⅳ期卵巢癌手术减瘤的适当推荐意见
Jing-Yi Chern,John P Curtin
Jing-Yi Chern
Epithelial ovarian cancer continues to be the leading cause of death due to gynecologic malignancy, and it is the fifth leading cause of cancer death in women in the USA and seventh worldwide. In most women with ovarian cancer, the disease ...
Aggressive B cell Lymphoma: Optimal Therapy for MYC-positive, Double-Hit, and Triple-Hit DLBCL [0.03%]
侵袭性B细胞淋巴瘤：MYC阳性、双打击和三重打击DLBCL的最佳治疗方案
Kieron Dunleavy
Kieron Dunleavy
Approximately 10% of cases of diffuse large B cell lymphoma (DLBCL) harbor a MYC rearrangement and this has been associated with an inferior outcome following standard therapy across many different studies. Double-hit and triple-hit lymphom...
Multicenter Study
Current treatment options in oncology. 2015 Dec;16(12):58. DOI:10.1007/s11864-015-0374-0 2015
Clinical Relevance of Androgen Receptor Splice Variants in Castration-Resistant Prostate Cancer [0.03%]
去势抵抗性前列腺癌中雄激素受体剪接变体的临床意义
Benjamin L Maughan,Emmanuel S Antonarakis
Benjamin L Maughan
Metastatic castration-resistant prostate cancer (mCRPC) currently benefits from a wealth of treatment options, yet still remains lethal in the vast majority of patients. It is becoming increasingly understood that this disease entity contin...
Kaname Nosaki,Takashi Seto
Kaname Nosaki
The standard therapy for limited disease small cell lung cancer (LD-SCLC) is concurrent chemoradiotherapy and prophylactic cranial irradiation (PCI) for those who achieve complete remission (CR) or good partial response (PR) with initial th...
Michelle Davis,Sarah Feldman
Michelle Davis
Since the publication of the American Cancer Society (ACS)/American Society for Colposcopy and Cervical Pathology (ASCCP)/American Society for Clinical Pathology (ASCP) clinical guidelines in 2012, the majority of practice organizations hav...
An Update on the Role of Immunotherapy and Vaccine Strategies for Primary Brain Tumors [0.03%]
免疫疗法和疫苗策略在原发性脑肿瘤治疗中的作用更新
Martha R Neagu,David A Reardon
Martha R Neagu
Existing therapies for glioblastoma (GBM), the most common malignant primary brain tumor in adults, have fallen short of improving the dismal patient outcomes, with an average 14-16-month median overall survival. The biological complexity a...
Joseph Menczer
Joseph Menczer
Surgery is the primary treatment for uterine carcinosarcoma (UCS). Lymphadenectomy should be performed for staging purposes in tumors apparently confined to the uterus. Most studies found that lymphadenectomy is of therapeutic value. The th...
First-Line Treatment of Metastatic Colorectal Cancer: Interpreting FIRE-3, PEAK, and CALGB/SWOG 80405 [0.03%]
转移性结直肠癌一线治疗：FIRE-3、PEAK和CALGB/SWOG 80405研究解读
Elena Elez,Guillem Argilés,Josep Tabernero
Elena Elez
The advances made in the therapeutic management of colorectal cancer (CRC) over recent years with the addition of therapies targeting angiogenesis or cell proliferation have positioned bevacizumab, cetuximab, and panitumumab as accepted fir...
Generations of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Perils and Progress [0.03%]
表皮生长因子受体酪氨酸激酶抑制剂的世代变迁：挑战与进步
Emily H Castellanos,Leora Horn
Emily H Castellanos
Epidermal growth factor receptor (EGFR) mutations have been detected in approximately 10 % of North American patients diagnosed with non-small cell lung cancer (NSCLC). Approximately 90 % of these mutations are exon 19 deletions or exon 21 ...