Next-Generation Checkpoint Combinations: Optimizing PD-(L)1-Based Therapy Across the Advanced, Adjuvant, and Neoadjuvant Settings [0.03%]
下一代免疫治疗联合方案：在晚期、辅助和新辅助设置中优化PD-(L)1-based疗法
Fausto Petrelli,Lara Colombo Zefinetti,Andrea D&#x;Alessio et al.
Fausto Petrelli et al.
Purpose of review: Programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors are foundational components of therapy across many solid tumors, yet primary and acquired resistance limit durable benefit...
Revisiting the Immunological Landscape of Locoregional Therapies for Gastrointestinal Cancers: A Shift Toward Interventional Immuno-Oncology [0.03%]
胃肠道肿瘤局部区域治疗的免疫微环境：向干预性免疫肿瘤学转变
Augustin Suffisseau,Johanne Seguin,Katia Lemdani et al.
Augustin Suffisseau et al.
Purpose of review: Locoregional therapies have emerged as key components in the therapeutic arsenal against gastrointestinal cancers, offering minimally invasive options with curative potential. Beyond their direct cytoto...
Claudia Trojaniello,Antonella Lucia Marretta,Bianca Arianna Facchini et al.
Claudia Trojaniello et al.
Purpose of review: The advent of anti-PD-1 therapy has transformed the treatment paradigm of advanced melanoma, enabling durable responses in a proportion of patients. However, the impact of both primary and acquired resi...
Sacituzumab Tirumotecan Across Gynecologic Malignancies: One Target, Multiple Diseases [0.03%]
靶向撒奇图单抗- tirumotecan在妇科恶性肿瘤中的应用：一种靶点，多种疾病
Amalia A Sofianidi,Evangelia Panagodimou,Emmanouil Kalampokas et al.
Amalia A Sofianidi et al.
Purpose of review: Sacizuzumab Tirumotecan is a novel antibody-drug conjugate targeting TROP2 glycoprotein, which is highly expressed across malignant cells. Sacizuzumab Tirumotecan has already demonstrated promising clin...
Clusterin in Head and Neck Squamous Cell Carcinoma: Diagnostic, Prognostic, and Therapeutic Implications [0.03%]
细胞集群蛋白在头颈鳞癌中的诊断、预后和治疗意义
Ashmita Das,Vinay Bisen,Yogita Dhurandhar et al.
Ashmita Das et al.
Purpose of review: Head and neck squamous cell carcinoma (HNSCC) is a global malignancy characterised by extremely low survival rates, primarily contributed to by late diagnosis, tumour heterogeneity, and resistance to av...
Cardiac Risk Without a Roadmap: Lack of Evidence-Based Guidance for Cardiovascular Toxicity of T-Cell Redirecting Therapies [0.03%]
无地图的心脏风险：T细胞重定向治疗心脏毒性的证据缺乏指导
Serafino LaGalbo,Matthew T Foley,Anastasia E Metropulos et al.
Serafino LaGalbo et al.
Purpose of review: T-cell redirecting therapies have revolutionized the treatment of several hematologic malignancies. These include CAR T-cell therapy, an adoptive immunotherapy in which a patient's T-cells are engineere...
Current Understanding of CHIP's Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature [0.03%]
CHIP免疫生物学特征与胃肠病的关联研究进展综述
Kirti Arora,Rishi Chowdhary,Rachel McNulty et al.
Kirti Arora et al.
Purposeof review: Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the age-associated expansion of hematopoietic stem and progenitor cells (HSPCs) bearing somatic mutations in genes such as DNMT3...
The Role of EZH2 ın Malıgnant Pleural Mesothelıoma and Beyond: Current Practıce and Future Perspectıves [0.03%]
EZH2在恶性胸膜间皮瘤及其它肿瘤中的作用：现状与未来展望
Mehmet Kucukoner,Tarik Demir,Abduljalil Mohammed Alsubaie et al.
Mehmet Kucukoner et al.
Purpose of review: Malignant pleural mesothelioma (MPM) remains a rare but highly aggressive malignancy with limited treatment options and poor prognosis. For nearly twenty years, platinum-pemetrexed chemotherapy has pers...
Decoding Occult Cervical Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma: From AI-Driven Multimodal Fusion to Clinical Translation [0.03%]
头颈鳞癌 occult 颈部淋巴结转移的多模态融合及临床转化：从人工智能驱动到精准诊疗
Yun Lin,Ehab Hanna,Xinliang Pan et al.
Yun Lin et al.
Purpose of review: This review examines the limitations of conventional macroscopic approaches in detecting occult cervical lymph node metastasis (OCLNM). It also explores how multi-omics technologies and artificial intel...
PARP Inhibitors as Radiosensitizers: Current Evidence and Future Directions [0.03%]
PARP抑制剂作为放射增敏剂：现有证据和未来方向
Eurico Pereira,Filipa Pereira,Gabriela Campos et al.
Eurico Pereira et al.
Purpose of review: Radiotherapy remains a fundamental pillar of cancer treatment, however its efficacy is still often limited by tumor radioresistance and toxicity to surrounding healthy tissues. Poly(ADP-ribose) polymera...