Rethinking Lipid Burden and the Role of Non-LDL Biomarkers in Stroke Risk Stratification [0.03%]
重构血脂负担及非LDL生物标志物在卒中风险分层中的作用
Sean Michael Kelly,Julia Schneider,Michela Rosso et al.
Sean Michael Kelly et al.
Purpose of review: This article reviews the existing literature on non-LDL biomarkers in atherosclerotic cardiovascular disease (ACSVD), atherogenesis, and ischemic stroke risk, including a discussion of potential future ...
Triglyceride-Rich Lipoproteins and ASCVD: Evidence for Causality and Challenges in Therapeutic Translation [0.03%]
富含甘油三酯的脂蛋白与动脉粥样硬化性心血管疾病：因果关系的证据及治疗转化挑战
Elias Björnson,Martin Adiels
Elias Björnson
Purpose of review: This review summarizes current evidence linking triglyceride-rich lipoproteins (TRLs) to atherosclerotic cardiovascular disease (ASCVD) with emphasis on challenges in translating the epidemiological- an...
Combination cardiometabolic therapy in type 2 diabetes: optimizing SGLT2 inhibitor and GLP‑1 receptor agonist use [0.03%]
2型糖尿病的组合心血管疗法：优化SGLT2抑制剂和GLP-1受体激动剂的使用
Laura R Porterfield,Saad Nadeem,Dallin Swanson et al.
Laura R Porterfield et al.
Purpose of review: To evaluate the evidence supporting combined sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in type 2 diabetes, focusing on cardiometabolic ...
Huige Li,Ning Xia
Huige Li
Purpose of review: Social isolation and loneliness have emerged as important cardiovascular risk factors, yet the biological mechanisms linking adverse social experiences to cardiovascular disease remain incompletely unde...
The Role of Furin in Hallmarks of Aneurysms: A Focus On Its Substrates [0.03%]
furin在动脉瘤标志性特征中的作用——聚焦其底物蛋白质
Meiliang Wang,Ziyan Liu,Yu Qian et al.
Meiliang Wang et al.
Purpose of review: An aneurysm is a frequently occurring and potentially life-threatening cardiovascular disease. However, limited clinical therapeutic drugs are available. Here, we aimed to provide a framework for aneury...
The Angiopoietin-like Protein (ANGPTL) Axis in Dyslipidemia: Mechanisms, Cardiovascular Risk, and Emerging Therapies [0.03%]
脂代谢紊乱状态下血管生成素样蛋白（ANGPTL）轴的作用机制、心血管风险及新兴疗法研究进展
Isabela C Bitencourt,André Zimerman,Nicholas A Marston
Isabela C Bitencourt
Purpose of review: The angiopoietin-like protein (ANGPTL) 3-4-8 axis has emerged as a central regulator of lipoprotein lipase and lipid metabolism. This review examines the mechanistic basis of ANGPTL pathway modulation a...
The Evolving Role of Coronary Artery Imaging in Assessing Cardiovascular Risk from Lipoprotein(a) [0.03%]
冠状动脉成像在评估脂蛋白(a)心血管风险中的作用及演变关系的研究
Michael T Savides,Harpreet S Bhatia,Inna Kuznetsova et al.
Michael T Savides et al.
Purpose of review: Summarize current literature on the use of coronary artery imaging modalities in examining the atherosclerotic and arterial inflammatory manifestations of elevated lipoprotein(a) [Lp(a)]. Evaluate the e...
The Spectrum of Genetic Causes of Familial Hypercholesterolemia Phenotype [0.03%]
家族性高胆固醇血症表型的遗传原因谱系
M Bourbon,A C Alves,J R Chora et al.
M Bourbon et al.
Purpose of review: This paper reviews the genetic spectrum underlying the Familial Hypercholesterolemia (FH) phenotype, aiming to improve diagnosis, awareness and understanding of these inherited lipid disorders. ...
Targeting LDL Across the Whole Spectrum of Chronic Kidney Disease: From Pathophysiology to Novel Treatments [0.03%]
慢性肾病全程低密度脂蛋白干预：从发病机制到新型治疗策略
Roberto Minutolo,Luca De Nicola,Arturo Cesaro et al.
Roberto Minutolo et al.
Purpose of review: The natural fate of chronic kidney disease (CKD) is the progression to dialysis; however, most patients face fatal and nonfatal cardiovascular events throughout their lifetime. We here address the role ...
Overview of Novel Mechanisms in Obesity Pharmacotherapy and Implications for Cardiovascular Disease: A Narrative Review [0.03%]
肥胖药物治疗的新机制及其对心血管疾病的影响：叙述性综述
Michael Bonafede,Aditi Rao,Beverly G Tchang
Michael Bonafede
Purpose of review: While nutrient-stimulated hormone (NuSH) therapies (e.g., glucagon-like pepide-1 receptor agonists and dual/triple agonists) have transformed the landscape of obesity pharmacotherapy, the next generatio...