Familial Hypercholesterolemia in Women: Diagnosis, Treatment, and Cardiovascular Outcomes Across the Lifespan [0.03%]
女性家族性高胆固醇血症：一生中的诊断、治疗和心血管结局
Irene Karungi,Kirsten B Holven,Kausik K Ray et al.
Irene Karungi et al.
Purpose of review: Familial hypercholesterolemia (FH) is a common monogenic lipid disorder, characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and a markedly increased risk of atherosclerotic c...
Micro-and Nano-Plastic Exposure as an Emerging Risk for Atherosclerotic Cardiovascular Disease [0.03%]
微塑料和纳米塑料暴露对动脉粥样硬化性心血管疾病的新兴风险作用
Hira Tariq,Romaina Iqbal
Hira Tariq
Purpose of review: This review examines micro- and nanoplastic (MNP) exposure as an emerging risk factor for atherosclerotic cardiovascular disease, focusing on how individual-level exposures shaped by behaviours, micro-e...
Khalil Anchouche,Nicholas Koran,George Thanassoulis
Khalil Anchouche
Purpose of review: Elevated lipoprotein(a) (Lp[a]) is a prevalent, lifelong, and genetically determined causal cardiovascular risk factor, associated with a wide spectrum of cardiovascular disease, including atherosclerot...
Patient Engagement Strategies for Implementing Evidence-Based Care in Atherosclerosis [0.03%]
动脉粥样硬化证据护理实施的患者参与策略
Emily E Brown,Kathleen Byrne
Emily E Brown
Purpose of the review: Despite continuing therapeutic advances in cardiovascular disease, it remains a leading cause of morbidity and mortality in the US. The current challenge is not the development of therapeutics but r...
Desialylated vs. Oxidized LDL: Sialidase Inhibitors as Promising Antiatherosclerotic Agents [0.03%]
脱岩藻糖化与氧化低密度脂蛋白：岩藻糖酶抑制剂作为有前景的抗动脉粥样硬化药物
Alexander Nikolaevich Orekhov,Igor Aleksandrovich Sobenin
Alexander Nikolaevich Orekhov
Purpose of review: The accumulation of lipids, particularly cholesteryl esters, in the arterial intima is an early sign of atherogenesis. Although low-density lipoprotein (LDL) is the primary lipid donor in the circulatio...
Beyond the Coronaries: Utility of Extra-Coronary Calcification for Cardiovascular Risk Assessment in Women [0.03%]
冠状动脉以外：女性心血管风险评估中额外冠状动脉钙化的应用价值
Emily Littman,Syed Bukhari,Haley Watts et al.
Emily Littman et al.
Purpose of review: Globally, cardiovascular disease (CVD) is the leading cause of mortality in women. Traditional risk calculators underestimate atherosclerotic cardiovascular disease risk (ASCVD), particularly in women c...
To Reenvision and Redefine: Considering the Role of Lifestyle Interventions in the New Era of Second-Generation Obesity Management Medications [0.03%]
重新构想和重新定义：在二代肥胖症管理药物新时代中审视生活方式干预的作用
Alexandra Peary,Nainika Vaidya,John Jakicic et al.
Alexandra Peary et al.
Purpose of review: This narrative review examines lifestyle considerations before, during, and after second-generation obesity management medication (OMM) treatment. ...
Microcalcification: Effects on Atherosclerotic Vulnerable Plaques, Detection, and Therapeutic Perspectives [0.03%]
微钙化：对动脉粥样硬化易损斑块的影响、检测及治疗视角
Jia Xu,Dabei Cai,Zhongqun Wang
Jia Xu
Purpose of review: We aim to elucidate the formation mechanisms of microcalcification in atherosclerotic plaques, systematically clarify its heterogeneous effects on plaque vulnerability, and summarize the latest advances...
Gut Microbial Dysbiosis in Type 2 Diabetes Patients with Concurrent Atherosclerosis [0.03%]
动脉粥样硬化2型糖尿病患者肠道微生物菌群失调分析
Abdul Sammad,Sohrab Khan,Yao-Yuan Zhang et al.
Abdul Sammad et al.
Purpose of review: The association of the gut microbiome with T2DM has been conflicting due to the disease's inherent complexity-a challenge that is further exacerbated in T2DM-related atherosclerotic cardiovascular disea...
Pharmacogenomics of Atherosclerotic Plaque: Pathophysiological Background and Therapeutic Perspectives [0.03%]
动脉粥样硬化斑块的药理基因组学：病理生理背景与治疗前景
Alfredo Mauriello,Aldo De Falco,Adriana Correra et al.
Alfredo Mauriello et al.
Purpose of review: Advances in pharmacogenomics have paved the way for personalized medicine. Cardiovascular diseases still represent the leading cause of mortality worldwide. This review aims to summarize the background,...