Timothy A Vortherms,Bryan L Roth
Timothy A Vortherms
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum has been increasingly used recreationall...
Immunodeficiency is a tough nut to CRAC: the importance of calcium flux in T cell activation [0.03%]
免疫缺陷难以通过CRAC克服：T细胞活化过程中钙离子流动的重要性
Helen P Carroll,Benjamin B A McNaull,Massimo Gadina
Helen P Carroll
Severe Combined Immunodeficiency (SCID) is a rare primary immunodeficiency disease often characterized by a block in T cell development, which may also affect the normal development of B cells and NK cells. Several different mutations are k...
Molly J Carlson,David E Cummings
Molly J Carlson
In the battle to treat the pandemic of obesity, one therapeutic strategy is to block endogenous signals that stimulate appetite and control body weight. One such molecule is ghrelin, a gut peptide that is the only known orexigenic hormone a...
Unraveling the structure of the variola topoisomerase IB-DNA complex: a possible new twist on smallpox therapy [0.03%]
解开天花拓扑异构酶IB-DNA复合物的结构：可能的新疗法视角
Neil Osheroff
Neil Osheroff
Smallpox is a serious and highly contagious disease that is caused by the variola virus. It is one of the most severe infectious human diseases known, with mortality rates as high as 30%. A successful worldwide vaccination program led to th...
Roadmap or roadkill: a pharmacologist's analysis of the NIH Molecular Libraries Initiative [0.03%]
道路或障碍：NIH分子图书馆计划的药理学分析
John S Lazo
John S Lazo
Allan E Rettie,Guoying Tai
Allan E Rettie
Warfarin, a coumarin anticoagulant, is used worldwide for the treatment and prevention of thromboembolic disease. Warfarin therapy, however, can be difficult to manage because of the drug's narrow therapeutic index and the wide interindivid...
Elizabeth Jonas
Elizabeth Jonas
Mitochondria are the predominant organelle within many presynaptic terminals. During times of high synaptic activity, they affect intracellular calcium homeostasis and provide the energy needed for synaptic vesicle recycling and for the con...
Ravindra Rajakariar,Muhammad M Yaqoob,Derek W Gilroy
Ravindra Rajakariar
Aspirin and the other NSAIDs have popularized the notion of inhibiting prostaglandins as a common anti-inflammatory strategy based on the erroneous premise that all eicosanoids are, within the context of inflammation, generally detrimental....
Wolfgang Sadée,Laura Bohn
Wolfgang Sadée
With the push to develop the next blockbuster drugs, continued surveillance of current bestsellers may not be given the full attention due. Upon wide-spread use, unexpected adverse effects begin to emerge. Although touted as highly specific...
Paula H Stern
Paula H Stern
New findings reveal that the calcineurin-NFAT signaling pathway helps to promote osteoblast differentiation. Three recent papers reveal somewhat different mechanisms by which this could occur. In one study, transduction of calcineurin Aalph...