Irina Zabbarova,Anthony Kanai
Irina Zabbarova
Adverse effects of ionizing radiation are mediated through reactive oxygen and nitrogen species. Mitochondria are the principal source of these species in the cell and play an important role in irradiation-induced apoptosis. The use of free...
Caenohabditis elegans in Parkinson's disease drug discovery: addressing an unmet medical need [0.03%]
帕金森病药物研发中的线虫模型：解决未被满足的医疗需求
Richard Nass,Kalpana M Merchant,Timothy Ryan
Richard Nass
It has been over forty years since dopamine neuron degeneration in the substantia nigra and Lewy body formation within surviving cells were described as the pathological hallmarks of Parkinson's disease (PD). Although research in the interv...
Let's go rafting: ligand functional selectivity may depend on membrane structure [0.03%]
让我们去激流勇进：配体功能选择性可能取决于膜结构
Mark A Simmons
Mark A Simmons
The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers? [0.03%]
唯一的出路是上行：通过促进MOR-DOR异二聚体的细胞表面表达来预防阿片类药物耐受性？
Richard M van Rijn,Jennifer L Whistler
Richard M van Rijn
Something old... something blue [0.03%]
旧情新爱
Stanley Scheindlin
Stanley Scheindlin
David R Robinson,G F Gebhart
David R Robinson
Most of what is written and believed about pain and nociceptors originates from studies of the "somatic" (non-visceral) sensory system. As a result, the unique features of visceral pain are often overlooked. In the clinic, the management of...
Jean-Martin Beaulieu,Marc G Caron
Jean-Martin Beaulieu
Lithium and other mood-stabilizing drugs are used for the management of bipolar mood disorders and, to a lesser extent, for augmentation of other psychoactive drugs. Lithium also has neuroprotective properties that may be useful for treatme...
Helge Eilers
Helge Eilers
Rebecca J Anderson
Rebecca J Anderson