Stanley Scheindlin
Stanley Scheindlin
Peter W Kalivas,Jamie Peters,Lori Knackstedt
Peter W Kalivas
Animal models in the field of addiction are considered to be among the best available models of neuropsychiatric disease. These models have undergone a number of refinements that allow deeper understanding of the circuitry involved in initi...
Qun-Yong Zhou
Qun-Yong Zhou
Secreted peptides play broad regulatory roles in brain function and elsewhere in the body. Prokineticins are a pair of newly identified regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins...
Linda K Friedman
Linda K Friedman
Sustained increases in intracellular calcium following prolonged seizures or other neurological insults have been thought to be responsible for neuronal cell death for well over two decades. For example, a seizure or a stroke can lead to ex...
Daniel S McGehee
Daniel S McGehee
Disrupting calcium channel expression to lower blood pressure: new targeting of a well-known channel [0.03%]
干扰钙通道表达以降低血压：针对熟知通道的新靶向治疗
Swapnil Sonkusare,Mony Fraer,James D Marsh et al.
Swapnil Sonkusare et al.
Scott Vrecko
Scott Vrecko
Who's afraid of ligand-macromolecule interactions in complex physiological systems? [0.03%]
谁害怕配体-大分子在复杂生理系统中的相互作用？
Nigel Shankley,Bryan F Cox,Laurence L Brunton
Nigel Shankley
Jack Bergman,Carol A Paronis
Jack Bergman
Animal models for human diseases are highly valued for their utility in developing new therapies. Animals have long provided suitable platforms for the development of innovative surgical procedures and for the study of disease states that a...
Philip J Hajduk
Philip J Hajduk
It has been nearly ten years since the introduction of SAR by NMR and the advent of fragment-based drug design. During this time, we have gained a tremendous amount of knowledge about protein druggability, the limits of chemical diversity, ...