Karl-Erik Andersson,George J Christ
Karl-Erik Andersson
Regenerative medicine technologies cross the boundaries of numerous scientific fields, including cell and molecular biology, chemical and material sciences (i.e., nanotechnology), engineering, molecular genetics, physiology and pharmacology...
Stress responsivity, addiction, and a functional variant of the human mu-opioid receptor gene [0.03%]
压力反应性、药物依赖以及人μ型阿片受体基因的功能多态性变异型式
Mary Jeanne Kreek,K Steven LaForge
Mary Jeanne Kreek
Discovery and characterization of the functional A118G mu-(mu)-opioid receptor variant led to hypotheses, now in part proven, about its role in alterations of endogenous human physiology and in responses to opioid antagonist administration....
Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection [0.03%]
环磷酸腺苷同工酶作为新颖的治疗标靶：兴奋毒性神经保护的令人振奋的例子
Val J Watts
Val J Watts
The use of transgenic animals lacking one or multiple adenylyl cyclase (AC) isoforms has provided significant information on the roles of AC-dependent signaling in the central nervous system. A recent study provides evidence that AC type 1 ...
Inhibiting sperm motility for male contraception: will the sperm tail be its "Achilles heel"? [0.03%]
通过抑制精子活动力实现男性避孕，“精子之踵”会在其尾巴上吗？
John K Amory
John K Amory
Blocking sperm motility has great appeal as a male contraceptive. A drug that targets sperm motility might have a very rapid onset of action, possibly allowing for administration immediately prior to intercourse and minimizing concerns abou...
Stanley Scheindlin
Stanley Scheindlin
Honoring Julius Axelrod [0.03%]
纪念尤利乌斯·阿克塞尔罗德
Harry B Smith
Harry B Smith
Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks? [0.03%]
NGF介导的伤害性感觉神经元敏化现象的故事：与Trk有关还是无关？
Grant D Nicol,Michael R Vasko
Grant D Nicol
Nerve Growth Factor (NGF) is produced by and affects a number of immune and inflammatory cells. As part of the inflammatory response, NGF directly or indirectly alters the sensitivity of small diameter sensory neurons that communicate noxio...
Holger Römpler,Claudia Stäubert,Doreen Thor et al.
Holger Römpler et al.
The common seven-transmembrane-domain (TMD) architecture of G protein-coupled receptors (GPCRs) has been preserved over a vast period of time, and highly conserved amino acid motifs and residues have evolved to establish ligand and signal t...
The fight against tamoxifen resistance in breast cancer therapy: a new target in the battle? [0.03%]
乳腺癌治疗中抵抗托美司汀的斗争：这场战斗中的一个新目标？
Mark Nichols
Mark Nichols
Tamoxifen is one of the most successful and widely used chemopreventive agents ever, and is an effective therapeutic agent for inhibiting growth of hormone receptor positive breast cancers. Tamoxifen and some of its metabolites bind to estr...
Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase? [0.03%]
奥卡姆剃刀与选择性雄激素受体调节剂(SARM)：我们是否忽视了5α-还原酶的作用？
Wenqing Gao,James T Dalton
Wenqing Gao
Selective Androgen Receptor Modulators (SARMs) are a novel class of AR ligands that possess tissue-selective pharmacological activities. SARMs of various chemical structures have been discovered and characterized, and lead compounds with mu...