Sue Piper Duckles
Sue Piper Duckles
John S Lazo
John S Lazo
Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms [0.03%]
泛素化调节受体和转运蛋白：出人意料的相似机制的新见解
Manuel Miranda,Alexander Sorkin
Manuel Miranda
The function of many receptors and transport proteins that reside at the surface of the cell is regulated by endocytosis and postendocytic trafficking. Modification of receptors and transporters by ubiquitin conjugation has recently emerged...
Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues [0.03%]
癌症化疗的牵连损害：非靶组织中的氧化应激
Yumin Chen,Paiboon Jungsuwadee,Mary Vore et al.
Yumin Chen et al.
Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or ...
Louis-Eric Trudeau,Rafael Gutiérrez
Louis-Eric Trudeau
Most neurons in the nervous system appear to contain and release more than one chemical acting as a neurotransmitter or neuromodulator. Cotransmission can therefore be considered the rule rather than the exception. Indeed, cotransmission of...
Aryl hydrocarbon receptor degradation-promoting factor (ADPF) and the control of the xenobiotic response [0.03%]
芳烃受体降解促进因子(ADPF)与外源性物质反应的控制
Qiang Ma
Qiang Ma
The study of xenobiotic metabolism has long been a core activity in pharmacology. The diverse chemical transformations of xenobiotics in vivo are elegant in themselves, depending as they do on a battery of enzymes that include the cytochome...
Dayle Houston
Dayle Houston
Brian M Cox
Brian M Cox
Vanja Petrovic,Shirley Teng,Micheline Piquette-Miller
Vanja Petrovic
Inflammation-induced changes in the pharmacokinetics and dynamics of numerous drugs have been reported. Altered drug disposition during inflammatory disease has traditionally been ascribed primarily to changes in drug metabolism and protein...
The pharmacology and signaling of bitter, sweet, and umami taste sensing [0.03%]
苦味、甜味和鲜味的感觉的药理及信号转导
R Kyle Palmer
R Kyle Palmer
Over the last decade, many of the molecular components that mediate the transduction of taste signaling have been elucidated. The chemosensory receptors for taste have been identified as G protein-coupled receptors (GPCRs) and ion channels ...