Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery [0.03%]
海锥螺神经毒素肽的多样性：一种协同药理学发现模式
Baldomero M Olivera,Russell W Teichert
Baldomero M Olivera
Predatory cone snails (genus Conus) produce a rich array of venoms that collectively contain an estimated 100,000 small, disulfide-rich peptides (i.e., conotoxins, or conopeptides). Over the last few decades, the conopeptides have revealed ...
Bridging knowledge gaps on the long road to regeneration: classical models meet stem cell manipulation and bioengineering [0.03%]
从再生的长远道路来看，经典模型与干细胞操作和生物工程技术相互结合以弥合知识空白
Panagiotis A Tsonis
Panagiotis A Tsonis
Research into tissue repair and regeneration is fought on many fronts. This article emphasizes that research into therapeutic tissue regeneration depends on diverse concepts and approaches. The interface between classical animal models, suc...
Karl Peter Giese
Karl Peter Giese
In the adult brain, cyclin-dependent kinase 5 (Cdk5) can be beneficial by contributing to memory formation or can be detrimental by causing neurodegeneration, and it is of great interest to understand this dichotomy. Currently, it remains l...
Stanley Scheindlin
Stanley Scheindlin
Lawrence D Mayer,Andrew S Janoff
Lawrence D Mayer
Cancer chemotherapy treatments typically employ drug combinations in which the dose of each agent is pushed to the brink of unacceptable toxicity; however, emerging evidence indicates that this approach may not be providing optimal efficacy...
Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents [0.03%]
纤毛门寡鞭毛纲虫 cyclic核苷酸信号转导机制：潜在的治疗靶点
Sunil Laxman,Joseph A Beavo
Sunil Laxman
Trypanosome infections cause several major human diseases, including sleeping sickness and Chagas disease, which affect millions of people in Africa and South America, respectively. Although adenosine 3',5'-monophosphate (cAMP) signaling an...
Andrei Goga,Christopher Benz
Andrei Goga
MicroRNAs (miRNAs or mirs) are small, non-coding RNAs that bind specific mRNAs and decrease their translation or increase their degradation. miRNAs may modulate the formation and maintenance of tumors by regulating oncogene and tumor suppre...
Microsomal prostaglandin E2 synthase: a safer target than cyclooxygenases? [0.03%]
微胞质前列腺素E2合成酶：比环氧化酶更安全的作用靶点吗？
Leo Timmers,Gerard Pasterkamp,Dominique P V de Kleijn
Leo Timmers
Non-steroidal anti-inflammatory drugs (NSAIDs) are inhibitors of the cyclo-oxygenase (COX)-1 and -2 activities of prostaglandin G/H synthase-1 and -2, respectively. They have been extensively used in the treatment of prostaglandin E(2)-medi...
Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels [0.03%]
一项痛苦的研究工作：一种选择性靶向Nav1.8钠通道的小分子抑制剂的鉴定
Anthony M Rush,Theodore R Cummins
Anthony M Rush
Voltage-gated sodium channels in nociceptive neurons are attractive targets for novel pain therapeutics. Although drugs that target voltage-gated sodium channels have proven value as pain therapeutics, the drugs that are currently available...
1921-1930 [0.03%]
1921至1930年
Dayle Houston
Dayle Houston