Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics [0.03%]
致癌性Ras诱导的细胞因子表达：抗癌治疗的新靶点
Brooke B Ancrile,Kevin M O&#x;Hayer,Christopher M Counter
Brooke B Ancrile
The Ras family of small guanosine triphosphatases normally transmit signals from cell surface receptors to the interior of the cell. Stimulation of cell surface receptors leads to the activation of guanine exchange factors, which, in turn, ...
Joanne Elliott
Joanne Elliott
Cytokine responses are stringently controlled by a family of proteinsSTAT3 termed the suppressors of cytokine signaling (SOCS), and deregulation of SOCS function is associated with many diseases, including several cancers, disorders in hema...
Kathrin Muegge,Sichuan Xi,Theresa Geiman
Kathrin Muegge
Histone modifications, specifically, methylation of lysine residues in histone 3 (H3), determine chromatin structure and accessibility for transcription. A recent study by Bernstein and Lander identified a unique pattern of H3 methylation a...
Stanley Scheindlin
Stanley Scheindlin
Pray for the welfare of government; since were it not for the fear of government; men would swallow each other alive.
Phase 0 clinical trials in cancer drug development: from FDA guidance to clinical practice [0.03%]
从FDA指南到临床实践：癌症药物研发中的Ⅱ期临床试验
Robert Kinders,Ralph E Parchment,Jay Ji et al.
Robert Kinders et al.
The Food and Drug Administration (FDA) recently introduced the Exploratory Investigational New Drug Guidance to expedite the clinical evaluation of new therapeutic and imaging agents. Early clinical studies performed under the auspices of t...
S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response [0.03%]
S-谷胱甘肽化：细胞应激的指标及未折叠蛋白反应的调节因子
Danyelle M Townsend
Danyelle M Townsend
The specific posttranslational modification of protein cysteine residues by the addition of the tripeptide glutathione is termed S-glutathionylation. This process is promoted by oxidative and nitrosative stress but also occurs in unstressed...
Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1 [0.03%]
化险为夷：激活辣椒素受体TRPV1以联合治疗成瘾性疾病
Peter M Blumberg
Peter M Blumberg
Drug interactions and drug specificity are core themes for the pharmacologist. The paper discussed in this Viewpoint exploits the former to attain the latter. How can one improve local anesthetics so that they block pain but permit normal s...
Bound to be different: neurotransmitter transporters meet their bacterial cousins [0.03%]
转运蛋白天作之合：神经递质 transporter 与细菌表亲相会
L Keith Henry,Jens Meiler,Randy D Blakely
L Keith Henry
The neurotransmitter transporters belonging to the solute carrier 6 (SLC6) family, including the gamma-aminobutyric acid (GAT), norepinephrine (NET), serotonin (SERT) and dopamine (DAT) transporters are extremely important drug targets of g...
John Parascandola
John Parascandola
On December 28, 1908, eighteen men met in the pharmacology lecture room of the Johns Hopkins University Medical School to establish the American Society for Pharmacology and Experimental Therapeutics (ASPET). In 2008, ASPET celebrates its C...
Beyond amyloid: the next generation of Alzheimer's disease therapeutics [0.03%]
超越淀粉样蛋白：阿尔茨海默病治疗的下一代疗法
Guy R Seabrook,William J Ray,Mark Shearman et al.
Guy R Seabrook et al.
The precise pathological events that cause cognitive deficits in Alzheimer's disease remain to be determined. The most widely held view is that accumulation of amyloid beta peptide initiates the disease process; however, with more than eigh...