Neuroscience was not even a word: an interview with Floyd Bloom [0.03%]
神经科学甚至都不是一个词——对Floyd Bloom的采访
F Bloom
F Bloom
Floyd Bloom says that he grew up, surrounded by doctors and pills, in a drug store in Dallas, where his father and uncles were pharmacists. He is a natural storyteller, readily recalling the people and events that have shaped his career. Hi...
R J Huxtable,S K Schwarz
R J Huxtable
K Gee
K Gee
H B Pollard,O Eidelman,K A Jacobson et al.
H B Pollard et al.
Pharmacogenomics is becoming a frontline instrument of drug discovery, where the drug-dependent patterns of global gene expression are employed as biologically relevant end points. In the case of cystic fibrosis (CF), cells and tissues from...
Macromolecular therapeutics: emerging strategies for drug discovery in the postgenome era [0.03%]
大分子药物治疗：后基因组时代的新药研究策略
R L Juliano,A Astriab-Fisher,D Falke
R L Juliano
The postgenome era offers a plethora of potential therapeutic targets. Many of these targets will be addressable using small organic molecules as drug candidates. However, certain aspects of cell function, particularly those that rely on pr...
Selective inhibitors of cyclooxygenase-2: a growing class of anti-inflammatory drugs [0.03%]
选择性环氧合酶-2抑制剂：一类新型抗炎药物
I A Mardini,G A FitzGerald
I A Mardini
For about two years, selective inhibitors of cyclooxygenase-2 have been hailed as powerful additions to the armamentarium of nonsteroidal anti-inflammatory drugs (NSAIDs). Predicted by financial analysts to become among the pharmaceutical i...
Innate immunity in Alzheimer's disease: a model for local inflammatory reactions [0.03%]
阿尔茨海默病中的先天免疫：局部炎症反应的模型
E G McGeer,P L McGeer
E G McGeer
Over the past fifteen years, evidence has been accumulating that there is a chronic inflammatory reaction in areas of the brain affected by Alzheimer's disease. Chronic inflammation, which arises in reaction to an underlying pathology, repr...
A G Gilman
A G Gilman
Alfred Goodman Gilman was born in the same year (1941) that his father and Louis Goodman published the first edition of The Pharmacological Basis of Therapeutics. Pharmacology has thus always been part of his life, and in his own career he ...
R J Huxtable
R J Huxtable
Transcription of the multidrug resistance gene MDR1: a therapeutic target [0.03%]
多药耐药基因MDR1的转录：一个治疗靶点
K W Scotto,R A Johnson
K W Scotto
Two decades ago, the overexpression of P-glycoprotein (Pgp) was first demonstrated to mediate the energy-dependent efflux of a variety of chemotherapeutic agents from tumor cells, resulting in the development of multidrug resistance (MDR). ...