Andrew Lakoff
Andrew Lakoff
F Liu,K W Liang,L Huang
F Liu
Skeletal muscle is a promising target tissue for the gene therapy of both muscle and non-muscle disorders. Gene transfer into muscle tissue can produce a variety of physiologically active proteins and may ultimately be applied to the treatm...
J Lai,M H Ossipov,T W Vanderah et al.
J Lai et al.
One of the curious but common consequences of opioid administration in the clinical setting is the induction, at sites uninvolved in the original presentation of discomfort, of pain itself. The induction of pain is also a reliable, measurab...
M Overduin,M L Cheever,T G Kutateladze
M Overduin
When the outside of cell is stimulated,the inside generates a flurry of signals. Phosphates are sprinkled over lipids and proteins,where they are recognized within diverse signaling pathways. The kinases that congregate beneath the cell sur...
The mutability of blue [0.03%]
蓝色的变异性
R J Huxtable
R J Huxtable
R Merenstein,M A Bowdy,M Woolley
R Merenstein
A Roopra,Y Huang,R Dingledine
A Roopra
Neurons regulate the expression of genes essential to individual neuron function through elegant combinatorial interactions among a limited number of transcription factors. In addition, an economy of regulatory control is practiced within t...
A GABA(B) mystery: the search for pharmacologically distinct GABA(B) receptors [0.03%]
一个GABA(B)之谜：寻找药理学上不同的GABA(B)受体
S J Enna
S J Enna
The classification of neurotransmitter receptors into distinct pharmacological subtypes is of major importance in drug discovery. This quest is particularly important for neurotransmitter systems that are widely distributed. Because gamma-a...
Gamma-secretase: a catalyst of Alzheimer disease and signal transduction [0.03%]
γ-分泌酶：一种老年性痴呆和信号转导的催化剂
Y M Li
Y M Li
Gamma-secretase is a membrane-bound protease that cleaves within the transmembrane region of the amyloid precursor protein to generate the C termini of both major peptides that constitute the amyloid plaques found in Alzheimer disease (AD)....